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Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validierenRelevance Score | ABIN | Application | Konjugat | Host | Isotype | Epitope | Hersteller | Clonality | References | Details |
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1 | ABIN463336 | WB | Rabbit | IgG | N-Term | Anmelden zum Anzeigen | Polyclonal | 0 |
General |
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Antigen | Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) Antikörper |
Epitop | N-Term Alternativen |
Reaktivität | Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus), Yeast (Saccharomyces cerevisiae), Zebrafisch (Danio rerio) Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Unkonjugiert Alternativen |
Applikation |
Western Blotting (WB)
Alternativen
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1 Publikation vorhanden |
Hersteller | Anmelden zum Anzeigen |
ProduktdetailsAntigendetails Anwendungsinformationen Handhabung Referenzen Bilder |
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Blocking Peptide | Zu diesem Produkt passt das Blocking Peptide ABIN985813. |
Sequenz | MALKRINKEL SDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF |
Homologie | Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 100%, Yeast: 92%, Zebrafish: 92% |
Produktmerkmale | This is a rabbit polyclonal antibody against UBE2D3. It was validated on Western Blot using a cell lysate as a positive control. |
Reinigung | Affinity Purified |
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human UBE2D3 |
AntigendetailsProduktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | UBE2D3 (UBE2D3 Antibody Abstract) |
Hintergrund |
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D3 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. Alias Symbols: E2(17)KB3, MGC43926, MGC5416, UBC4/5, UBCH5C Protein Interaction Partner: NHLRC1, DTX2, TRIM63, RNF146, RNF26, RBX1, UBC, RNF5, RNF2, NEDD4, MID1, STUB1, TRIM39, OTUB1, MDM2, RNF111, TRIM33, PRPF19, RNF115, TRIM58, BTRC, MARCH7, NFKBIA, ARIH1, FBXW11, UBE2D3, PARK2, BRCA1, BARD1, UBE3A, MSL1, UBA1, CBLC, SMURF1, RNF130, UBA6, M Protein Size: 147 |
Molekulargewicht | 17 kDa |
Gen-ID | 7323 |
NCBI Accession | NM_003340, NP_003331 |
UniProt | P61077 |
Pathways | Activation of Innate immune Response, Toll-Like Receptors Cascades |
AnwendungsinformationenProduktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben |
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Applikationshinweise | Optimal working dilutions should be determined experimentally by the investigator. |
Kommentare |
Antigen size: 147 AA |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben |
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Format | Liquid |
Konzentration | Lot specific |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Konservierungsmittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Avoid repeated freeze-thaw cycles. |
Lagerung | -20 °C |
Informationen zur Lagerung | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
ReferenzenProduktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Allgemeine Veröffentlichungen |
Hattori, Zhang, Jia, Subramanian, Jo, Loison, Newburger, Luo: "RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells." in: Blood, Vol. 110, Issue 2, pp. 640-50, 2007 |
BilderProduktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben |
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Bilder des Herstellers |