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association of TNIP1 was stronger in AIH without HLA-DRB1*04:05 allele (P = 0.0063, Q = 0.0127, OR 1.48, 95% CI: 1.12-1.96), though the association was not detected in AIH with DRB1*04:05
Naf1 contributes to the maintenance of HIV-1 latency by inhibiting long terminal repeat driven HIV-1 gene transcription in a nuclear factor kappa B-dependent manner.
the risk allele for the TNIP1 rs7708392 polymorphism was associated with systemic lupus erythematosus susceptibility.
C/EBP beta (zeige CEBPB Proteine) LAP isoform expression was increased and LIP/TNFAIP3 (zeige TNFAIP3 Proteine)/TNIP1 expression was decreased in systemic lupus erythematosus (SLE) patients. LAP expression was positively correlated with SLE disease activity; TNFAIP3 (zeige TNFAIP3 Proteine) and TNIP1 expression was negatively correlated with SLE disease activity.
genetic variation in TNIP1 gene is associated with gastric carcinoma
An association of the GPX3-TNIP1 locus with ALS is identified using cross-ethnic meta-analyses. [Meta-Analysis]
These studies define a novel role for ABIN1 dysfunction and NF-kappaB (zeige NFKB1 Proteine) in mediating glomerulonephritis through proinflammatory activation of podocytes.
IM could upregulate A20 (zeige TNFAIP3 Proteine) protein to inhibit the activation of NF-kappaB (zeige NFKB1 Proteine) pathway in Jurkat T cells, which was independent of the ABIN1 protein.
LILRB1 (zeige LILRB1 Proteine) ligation during monocyte differentiation to dendritic cells in vitro increases ABIN1 expression. Increased ABIN1 expression occurs in "immunosuppressive" monocytes of patients with non-Hodgkin lymphoma ex vivo. ABIN1 siRNA allows dendritic cells and immunosuppressive monocytes to respond to stimulation by allowing NF-kappaB (zeige NFKB1 Proteine) translocation to the nucleus, more phagocytosis, cytokine secretion, and T-cell stimulation.
These findings show ABIN1 as an intrinsic suppressor of HIV-1 mRNA transcription by regulating the ubiquitination of Tat (zeige TAT Proteine).
the data establish Tnip1 as a critical regulator of IL-17 (zeige IL17A Proteine) biology and reveal a causal role of keratinocytes in the pathogenesis of psoriasis.
Suppression of IRAK1 (zeige IRAK1 Proteine) or IRAK4 (zeige IRAK4 Proteine) Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1
These results suggest that the ABIN1-mediated hyperactivation of IKKs and MAPKs might mediate chronic inflammation and CVD development.
studies link ABIN-1 with IL-23 (zeige IL23A Proteine) and IL-17 (zeige IL17A Proteine), and they provide cellular and molecular mechanisms by which ABIN-1 regulates susceptibility to psoriasis.
data reveal ABIN1 as an essential anti-inflammatory component of TLR-signaling pathways that controls C/EBPbeta (zeige CEBPB Proteine) activity
ABIN1 requires its ubiquitin binding domain and cooperates with TAX1BP1 (zeige TAX1BP1 Proteine) and A20 (zeige TNFAIP3 Proteine) to restrict antiviral signaling.
the interaction of ABIN1 with polyubiquitin (zeige UBB Proteine) is required to limit the activation of TLR-MyD88 (zeige MYD88 Proteine) pathways and prevent autoimmunity
Using a murine model of allergen-induced asthma, we have demonstrated that adenovirus-mediated delivery of ABIN-1 to the lung epithelium results in a reduction of allergen-induced eosinophil infiltration into the lungs.
ABIN-1 inhibits caspase 8 (zeige CASP8 Proteine) recruitment to FADD (zeige FADD Proteine) (Fas (zeige FAS Proteine)-associated death domain-containing protein) in TNF (zeige TNF Proteine)-induced signalling complexes, preventing caspase 8 (zeige CASP8 Proteine) cleavage and programmed cell death.
we cloned the pig ABIN-1 gene to investigate its potential effects on pig reproduction traits.
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene.
A20-binding inhibitor of NF-kappa-B activation 1
, HIV-1 Nef-interacting protein
, Nef-associated factor 1 SNP
, TNFAIP3-interacting protein 1
, virion-associated nuclear shuttling protein
, A20-binding inhibitor of NF-kappa B activation
, Nef-associated factor 1
, TNFAIP3 interacting protein 1
, A20 binding and inhibitor of NF-kB protein 1
, TNFAIP3-interacting protein 1-like