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This gene encodes a secreted peptide that displays antimicrobial (zeige REG3A Proteine)activity against Gram-positive bacteria.
a model of CagA (zeige S100A8 Proteine)-directed REG3gamma expression in gastric epithelial cells via activation of the IL-11 (zeige IL11 Proteine)/gp130 (zeige IL6ST Proteine)/STAT3 (zeige STAT3 Proteine) pathway
REG III (zeige REG3A Proteine) was identified and expressed predominantly in pancreas and testis, but not in small intestine
PAP IB represents a good example of duplication and divergence, probably with the acquisition of new functions, thus participating in the evolution of the protein repertoire.
Reg3g acts as an immunosuppressive promoter by activating the JAK2 (zeige JAK2 Proteine)/STAT3 (zeige STAT3 Proteine) signaling pathway in dendritic cells and triggering the generation of an immunosuppressive tumor microenvironment.
The study shows that cardiac stress activates Reg3gamma expression and p38 MAPK (zeige MAPK14 Proteine) is an upstream regulator of Reg3gamma gene expression in heart. Altogether the data suggest Reg3gamma is associated with cardiac inflammatory signaling.
Recombinant IFN-I or IFN-I expression induced by RIG-I (zeige DDX58 Proteine) promoted growth of intestinal organoids in vitro and production of the antimicrobial peptide (zeige CAMP Proteine) regenerating islet-derived protein 3 gamma (RegIIIgamma).
Intestinal deficiency in REG3B or REG3G increases numbers of mucosa-associated bacteria and enhances bacterial translocation to the mesenteric lymph nodes and liver.
Administration of vancomycin downregulates RegIIIgamma and IL-17 (zeige IL17A Proteine) expression in skin wounds.
antibacterial function for lung epithelium through Stat3 (zeige STAT3 Proteine)-mediated induction of Reg3gamma.
Expression of Reg3 (zeige REG3A Proteine) proteins and Ang4 (zeige ANGPT4 Proteine) by goblet cells point to an important role for goblet cells in innate defense.
Reg (zeige KCNH2 Proteine)-IIIgamma expression is mainly observed in epithelial cells of the airways and intestine, but not in the nervous system; expression levels show a gradually increasing pattern along with development.
Letter: aggregation status of PAP1 and PAP2 (zeige MYBBP1A Proteine) could change their role in regulating the inflammation in acute pancreatitis.
Expression of Reg (zeige KCNH2 Proteine) proteins in embryonic stem cells is modulated by Wnt (zeige WNT2 Proteine)/beta catenin (zeige CTNNB1 Proteine) signaling.
This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antibacterial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms.
, pancreatitis-associated protein 1B
, pancreatitis-associated protein IB
, reg III-gamma
, regenerating gene III
, regenerating islet-derived protein 3-gamma
, regenerating islet-derived protein III-gamma
, RegIII (gamma)
, generating islet-derived, mouse homolog 3 gamma
, pancreatitis-associated protein 3
, regenerating islet-derived protein 3 gamma
, regenerating islet-derived family member 3
, pancreatic thread protein
, regenerating islet-derived 3 alpha