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Human MAVS Protein expressed in HEK-293 Cells - ABIN2725562
He, Zhu, Wen, Yuan, Hu, Chen, An, Dong, Lin, Yu, Wu, Yang, Cai, Li, Li: Dengue Virus Subverts Host Innate Immunity by Targeting Adaptor Protein MAVS. in Journal of virology 2016
these results demonstrated that HAUS8 (zeige HAUS8 Proteine) may function as a positive regulator of RLRVISA dependent antiviral signaling by targeting the VISA complex, providing a novel regulatory mechanism of antiviral responses
results suggest that ASC (zeige PYCARD Proteine), as a negative regulator of the MAVS-mediated innate immunity, may play an important role in host protection upon virus infection
Using MAVS as a platform, NLRP11 degrades TRAF6 (zeige TRAF6 Proteine) to attenuate the production of type I IFNs as well as virus-induced apoptosis. Our findings reveal the regulatory role of NLRP11 in antiviral immunity by disrupting MAVS signalosome.
Low MAVS expression is associated with RNA virus infections.
MCCC1 (zeige MCCC1 Proteine) plays an essential role in virus-triggered, MAVS-mediated activation of NF-kappaB (zeige NFKB1 Proteine) signaling.
The down regulation of TRIF (zeige TRIM69 Proteine), TLR3 (zeige TLR3 Proteine), and mitochondrial antiviral signaling protein (MAVS) expressions in chronic hepatitis C correlates with the disease severity and the outcome of hepatitis C virus infection
Taken together, these findings reveal an essential role of CypA (zeige PPIA Proteine) in boosting RIG-I (zeige DDX58 Proteine)-mediated antiviral immune responses by controlling the ubiquitination of RIG-I (zeige DDX58 Proteine) and MAVS.
Data show that human cytomegalovirus (HCMV; human betaherpesvirus 5) glycoprotein US9 inhibits the IFN-beta (zeige IFNB1 Proteine) response by targeting the mitochondrial antiviral-signaling protein (MAVS) and stimulator of interferon (zeige IFNA Proteine) genes (STING)-mediated signaling pathways.
our results demonstrate that miR (zeige MLXIP Proteine)-22 negatively regulates poly(I:C)-induced production of type I interferon (zeige IFNA Proteine) and inflammatory cytokines via targeting MAVS.
this analysis did not indicate the association of the MAVS locus with susceptibility to Addison's disease and type 1 diabetes
these data suggest that while MAVS signaling has a considerable impact on Treg identity, this effect is not mediated by intrinsic MAVS signaling but rather is likely an effect of the overproduction of pro-inflammatory cytokines generated in MAVS-deficient mice after WNV infection.
MAVS was identified as a main player in HDV detection and adaptive immunity was found to be involved in the amplification of the innate immune response.
MAVS is essential for spontaneous high basal expression of IFN-beta (zeige IFNB1 Proteine) in cardiac myocytes and the heart.
findings suggest that oxidative stress-induced (zeige SQSTM1 Proteine) MAVS oligomerization in SLE patients may contribute to the type I IFN signature that is characteristic of this syndrome.
this study shows that keratinocytes are an important source of IFN-beta (zeige IFNB1 Proteine) and MAVS is critical to this function, and demonstrates how the epidermis triggers unwanted skin inflammation under disease conditions
RIPK3 (zeige RIPK3 Proteine) regulates type I IFN both transcriptionally, by interacting with MAVS and limiting RIPK1 (zeige RIPK1 Proteine) interaction with MAVS, and post-transcriptionally.
Data suggest that activation of either RIG-I (zeige DDX58 Proteine)/MAVS or STING pathways during acute intestinal tissue injury in mice resulted in IFN-I signaling that maintained gut (zeige GUSB Proteine) epithelial barrier integrity and reduced GVHD severity.
this paper identifies TRIM31 (zeige TRIM31 Proteine), an E3 ubiquitin ligase (zeige MUL1 Proteine) of the TRIM (zeige TRAT1 Proteine) family of proteins, as a regulator of MAVS aggregation
Taken together, these results suggest that MAVS is essential for boosting optimal primary CD4 (zeige CD4 Proteine)(+) T cell responses upon NS4B-P38G West Nile virus vaccination and yet is dispensable for host protection and recall T cell responses during secondary wild-type West Nile virus infection.
this study demonstrates that the capacity of hepatitis A virus to evade MAVS-mediated type I interferon (zeige IFNA Proteine) responses defines its host species range.
The authors determined that porcine reproductive and respiratory syndrome virus 3C protease cleaved MAVS at Glu268.
Real-time quantitative PCR analysis indicated that Tibetan porcine IPS-1 (zeige ISYNA1 Proteine) mRNA was most abundant in the liver and kidney.
Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7 (zeige IRF7 Proteine)
Data show that mitochondrial antiviral signaling protein (MAVS) splicing variant 1 (MAVS_tv1) cooperated with DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 RIG-I (zeige DDX58 Proteine) in the accumulation of RIG-I (zeige DDX58 Proteine) transcript in a positive feedback loop.
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene.
CARD adapter inducing interferon beta
, CARD adaptor inducing IFN-beta
, IFN-B promoter stimulator 1
, interferon beta promoter stimulator protein 1
, mitochondrial antiviral-signaling protein
, putative NF-kappa-B-activating protein 031N
, virus-induced signaling adaptor
, virus-induced-signaling adapter
, virus-induced signaling adapter
, IFN-beta promoter stimulator-1
, mitochondrial anti-viral signaling protein
, mitochondrial IFN-beta promoter stimulator 1
, interferon-beta promoter stimulator protein 1