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Human Polyclonal HSPD1 Primary Antibody für ICC, IHC (p) - ABIN3044334
Cui, Du, Lu, Qiang: Cloning of the heat shock protein 60 gene from the stem borer, Chilo suppressalis, and analysis of expression characteristics under heat stress. in Journal of insect science (Online) 2010
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Human Polyclonal HSPD1 Primary Antibody für ICC, IHC (p) - ABIN3043854
Hager, Li, Pun, Liu, Hossain, Maguire, Naples, Baker, Magomedova, Tam, Adeli, Cummins, Connelly, Ng: Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice. in The Journal of biological chemistry 2012
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Human Polyclonal HSPD1 Primary Antibody für FACS, IHC (p) - ABIN1882094
Aboulaich, Vainonen, Strålfors, Vener: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. in The Biochemical journal 2004
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Chicken Monoclonal HSPD1 Primary Antibody für IHC (p), WB - ABIN3043649
Li, Nan, Zhai, Wang, Si, Chang: Molecular cloning, characterization, and expression of hsp60 in caudal fin regeneration of Misgurnus anguillicaudatus. in Molecular and cellular biochemistry 2014
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Bombyx mori Monoclonal HSPD1 Primary Antibody für FACS, IP - ABIN361784
Verda, Kim, Ikehara, Statkute, Bronesky, Petrenko, Oyama, He, Link, Vahanian, Burt: Hematopoietic mixed chimerism derived from allogeneic embryonic stem cells prevents autoimmune diabetes mellitus in NOD mice. in Stem cells (Dayton, Ohio) 2008
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Human Monoclonal HSPD1 Primary Antibody für ICC, FACS - ABIN969200
López-Hoyos, Alvarez, Ruiz Soto, Blanco, José Bartolomé, Martínez-Taboada: Serum levels of antibodies to Chlamydia pneumoniae and human HSP60 in giant cell arteritis patients. in Clinical and experimental rheumatology 2009
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Human Polyclonal HSPD1 Primary Antibody für IF (p), IHC (p) - ABIN726080
Kengkoom, Ampawong: Chronic ingestion of high dosed Phikud Navakot extraction induces mesangiolysis in rats with alteration of AQP1 and Hsp60 expressions. in BioMed research international 2015
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Chicken Monoclonal HSPD1 Primary Antibody für IHC (p), WB - ABIN533232
Cheng, Hartl, Martin, Pollock, Kalousek, Neupert, Hallberg, Hallberg, Horwich: Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. in Nature 1989
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Human Polyclonal HSPD1 Primary Antibody für ICC, IF - ABIN4320149
Pontén, Gry, Fagerberg, Lundberg, Asplund, Berglund, Oksvold, Björling, Hober, Kampf, Navani, Nilsson, Ottosson, Persson, Wernérus, Wester, Uhlén: A global view of protein expression in human cells, tissues, and organs. in Molecular systems biology 2009
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Bacteria Monoclonal HSPD1 Primary Antibody für FACS, IHC - ABIN361786
Bason, Corrocher, Lunardi, Puccetti, Olivieri, Girelli, Navone, Beri, Millo, Margonato, Martinelli, Puccetti: Interaction of antibodies against cytomegalovirus with heat-shock protein 60 in pathogenesis of atherosclerosis. in Lancet (London, England) 2003
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Helicobacter pylori (Hp)-positive patients with gastritis or coronary heart disease produce IgG autoantibodies to a specific epitope (P1 peptide) of human heat shock protein (Hsp)60 homologous to Hp Hsp60 (HspB) in the sera. Monocytes respond to P1 by production of proinflammatory cytokines. Upregulation of proinflammatory cytokines by P1 contributes to the pathogenesis of Hp infection.
High HSP60 expression is associated with disease recurrence and progression in bladder cancer.
When conditioned media was immuno-depleted of Hsp60, there was a significant reduction in the release of TNF-alpha from the human umbilical vein endothelial cells.
The mechanism involved in the interaction of HSP60-Ass conjugate with HLA-DR-DRB allele considering the fact that Ass (1-42) is highly immunogenic in human and interactions evoked highly robust T-cell response through MHC class II binding predictions.
HSP60 showed pro-inflammatory properties in bronchial epithelial cells mediated by activation of TLR-4-related molecules.
HSP60 silencing deactivates the mTOR pathway to suppress glioblastoma progression
the effect of Hsp60 on differentiation and invasion of hepatocellular carcinoma cells might be associated with mitochondrial biogenesis
The results demonstrate that HSP60 participates in mitochondrial progesterone synthesis. These findings provide novel insights into progesterone synthesis in the human placenta and its role in maintaining pregnancy.
Clinical data showed that upregulation of miR-382/3-NT and downregulation of HSPD1/Trx were also observed in IgA nephropathy patients with renal interstitial fibrosis. These data supported a novel mechanism in which miR-382 targets HSPD1 and contributes to the redox imbalance in the development of renal fibrosis.
Low HSP60 expression is associated with beta-cell hypertrophy and dysfunction.
high level of ROS is needed for tumorigenesis and progression in tumors with low HSP60 expression
HSP60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis.
These findings shed some light on how a tumor cell may avert apoptosis using Hsp60 and point to the anti-cancer potential of drugs, such as CubipyOXA, which interfere with Hsp60/pC3 complex formation, and thus allow the apoptotic cascade to proceed.
The associations of diabetes, combined with the polymorphisms in the genes of fat mass and obesity-associated gene (FTO), interleukin 6 (IL-6), and heat shock protein 60 (HSPD1), with breast cancer risk and survival in a Chinese Han population, was evaluated.
27-Hydroxycholesterol upregulates the production of HSP60 in monocytic cells.
data indicate that HSP65 suppresses cholesterol efflux and increases cellular cholesterol content through an Lck-mediated pathway in T cells
Doxorubicin treatment of lung mucoepidermoid cells results in Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence.
Phosphorylation and subsequent transient degradation of mitochondrial Hsp60 during early hours of rotavirus-SA11 infection resulted in inhibition of premature import of nonstructural protein 4 into mitochondria, thereby delaying early apoptosis.
Data show that the interaction between cell cycle and apoptosis regulator 2 (CCAR2) and heat shock protein 60 (Hsp60) increases in the presence of rotenone.
NIP-SNAP-1 and -2 localized in the mitochondrial inner membrane space, whereas HSP60 localized in the matrix. Expression levels of NIP-SNAP-1 and -2 in cells were decreased by knockdown of HSP60, but not HSP10. The findings indicate that HSP60 promotes folding and maintains the stability of NIP-SNAP-1 and -2.
Wild type HSP60 displayed a heptameric single-ring structure in the absence of ATP. In contrast, HSP60 formed mainly a "football-type" complex with HSP10 in the presence of ATP and mediated the refolding of denatured substrate protein.
These results indicate that different tissues had different sensitivities to transport stress, possibly resulting in varying levels of cytoprotection by Hsp60 in the different tissues.
Thus, VP8 of bovine herpesvirus 1 may play a role in the deregulation of mitochondrial function through interaction with HSP60 of the host. This is consistent with the fact that bovine herpesvirus 1 infection is known to promote mitochondrial dysfunction.
This paper reports the localization of both GRP78 and HSP60 on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 in the sperm midpiece.
The ApoE-/- mice were fed with western-type diet and HSP60 was administrated orally or subcutaneously for potential vaccine against atherosclerosis. ApoE-/- mice with oral HSP60 administration group showed a significant reduction in plaque size at the aortic root; accompanied by increased Myeloid derived suppressor cells (CD11b+Gr1+) in peripheral blood and spleen.
Overexpressing hsp60 in cultured myoblasts induced only the expression of PGC1 1alpha, suggesting a correlation between Hsp60 overexpression and PGC1 1 alpha activation.
neonatal heart failure through HSP60 induction likely involves developmental defects and excessive apoptosis
Heat shock protein 60 stimulates the migration of vascular smooth muscle cells via Toll-like receptor 4 and ERK MAPK activation
TLR4 mediates HSP60-associated apoptosis and that HSP60 has an important role in cardiac myocyte injury, both apoptotic and necrotic.
a direct toxic effect of heat shock protein 60 towards neurons and oligodendrocytes in the CNS involving Toll-like receptor4 and MyD88 pathways
Dietary wolfberry elevated the xanthophyll concentrations and enhanced expression of BCO2 and heat shock protein 60, activated AMPKalpha2, potentiated mitophagy and mitochondrial biogenesis and enhanced lipid oxidation and secretion in the liver of mice.
It is concluded that nasal administration of HSP60 can inhibit atherosclerotic formation through immune tolerance which is established by Tregs depending on the induction of anti-inflammatory cytokine TGF-beta.
MnSOD is a substrate of the Hsp60 folding machinery.
In type 2 diabetes, there is hypothalamic insulin resistance and mitochondrial dysfunction due to downregulation of the mitochondrial chaperone HSP60. HSP60 reduction was due to a lack of proper leptin signaling and was restored by leptin treatment.
Data indicate that HMGB1 and HSP60 are expressed in a Myd88 dependent manner.
a novel interaction between APP and HSP60, which accounts for its translocation to the mitochondria.
myocardial ischemia activates an innate immune signaling via HSP60 and TLR4, which plays an important role in mediating apoptosis and inflammation during I/R.
This study characterized the agglutination effects of monoclonal antibodies to Hsp60 on H. capsulatum yeast cells by light microscopy, flow cytometry, dynamic light scattering, measuring zeta potential, and using optical tweezers.
ApoB and HSP60 epitope immunization significantly reduces early atherosclerotic lesion in Apobtm2SgyLdlrtm1Her/J mice
Hspd1 is an essential gene for early embryonic development in mice, while reducing the amount of Hsp60 by inactivation of one allele of the gene is compatible with survival to term as well as postnatal life.
cytosolic Hsp60 is likely to be a regulatory component of IKK complex and a mitochondrial factor that regulates cell survival via NF-kappaB pathway
Results demonstrate that LOX-1 functions as a receptor for Hsp60.
We documented how floral traits under selection by multiple pollinators can result in either an intermediate "compromise" between selective pressures (sex organs) or apparent specialization (corolla tube length) to one pollinator
Expression of HSP60A is post-transcriptionally regulated in a highly dynamic pattern during embryogenesis, even under heat-shock conditions. In contrast, in very stressful situations, its expression is upregulated transcriptionally over the entire embryo.
cloning, expression and genomic organization
Heat-shock protein 60 is required for blastema formation and maintenance during regeneration.
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.
60 kDa chaperonin
, 60 kDa heat shock protein, mitochondrial
, P60 lymphocyte protein
, chaperonin 60
, heat shock protein 65
, mitochondrial matrix protein P1
, short heat shock protein 60 Hsp60s1
, heat shock 60 kDa protein 1
, mitochondrial heat shock 60 kDa protein 1
, heat shock protein 60
, heat shock 60kDa protein 1 (chaperonin)
, 60 kDa heat shock protein, mitochondrial-like
, heat shock protein, 60 kDa
, 60-kDa heat shock protein, mitochondrial
, Hsp 60
, heat shock protein 60 kDa
, no blastema
, chaperonin GroEL
, mitochondrial chaperonin
, heat shock 60kD protein 1 (chaperonin)
, heat shock 60kDa protein 1
, heat shock protein 60 (liver)
, LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial