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association with PRAT4A is required for ligand-induced trafficking of TLR9 (zeige TLR9 ELISA Kits) to endolysosomes
Cell surface expression of TLR5 (zeige TLR5 ELISA Kits) is dependent on PRAT4A and restricted to neutrophils, classical monocytes and specific DC subsets.
Data suggest that CNPY3 interacts with the ATP-sensitive conformation of gp96 (zeige HSP90B1 ELISA Kits) to promote substrate loading. Our study has thus established CNPY3 as a TLR-specific cochaperone for gp96 (zeige HSP90B1 ELISA Kits).
PRAT4A is a novel protein associated with toll (zeige TLR4 ELISA Kits)-like receptor (TLR) 4 (zeige TLR4 ELISA Kits) that regulates cell surface expression of receptor complex TLR4 (zeige TLR4 ELISA Kits)/MD-2 (zeige LY96 ELISA Kits).
PRAT4A regulates the subcellular distribution and response of multiple toll (zeige TLR4 ELISA Kits)-like recaptors and is required for both innate and adaptive immune responses
single base mutant associates preferentially with TLR9 (zeige TLR9 ELISA Kits), and differentially interacts with TLR2 (zeige TLR2 ELISA Kits), 4 and 9
a mechanism for the differential trafficking of TLR1 (zeige TLR1 ELISA Kits) I602S variants, and highlight the distinct roles for PRAT4A and PRAT4B (zeige CNPY4 ELISA Kits) in the regulation of TLR1 (zeige TLR1 ELISA Kits) surface expression.
PRAT4A is associated with the immature form of TLR4 (MIM 603030) and regulates its cell surface expression (Wakabayashi et al., 2006
canopy 3 homolog (zebrafish)
, trinucleotide repeat containing 5
, Protein canopy homolog 3
, canopy 3 homolog
, protein canopy homolog 3
, protein canopy homolog 3-like
, trinucleotide repeat-containing gene 5 protein
, protein associated with Tlr4
, protein associated with toll-like receptor 4
, CAG repeat containing
, CTG repeat protein 4a
, expanded repeat domain, CAG/CTG 5
, expanded repeat-domain protein CAG/CTG 5
, protein associated with TLR4
, protein associated with Toll-like receptor 4A
, canopy 3