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These results suggest that functionally neutral polymorphisms in dectin-1 are widespread in pig populations
recognition of beta-glucans appeared cell type-specific as both dectin-1 and CR3 (zeige ITGAM ELISA Kits) are involved in the beta-glucan-mediated responses in pig macrophages.
Dectin-1 agonists selectively induce IgG1 class switching by direct stimulation of Dectin-1 on LPS (zeige TLR4 ELISA Kits)-activated B cells resulting in selective production of IgG1.
These results suggest that the intracellular domain, not ligand-binding domain, of Dectin-1 determines the species-specific ligand profile.
this study shows the critical role of Dectin-1 for inflammasome activation, restriction of parasite replication in macrophages, and mouse resistance to Leishmania amazonensis infection in vivo
results demonstrate that Dectin-1-triggered Card9 (zeige CARD9 ELISA Kits) signaling but not inflammasome activation can potently cross-prime Ag-specific cytotoxic T-cells, suggesting that this pathway would be a candidate for immunotherapy and vaccine development
Dectin 1 is highly expressed on macrophages in pancreatic ductal adenocarcinoma (PDA). Clec7a deletion is protective against PDA, however Clec7a does not have direct protumorigenic effects on transformed pancreatic ductal epithelial cells.
Dectin-1 does not play a major role in in phagocytosis and innate defense by phagocytes against Cryptococcus neoformans spores.
these results suggest that Dectin-1 expressed on CD11b (zeige ITGAM ELISA Kits)(+) dendritic cells (DCs) senses some molecule(s) in house dust mite (HDM (zeige HDAC3 ELISA Kits)) extract and plays a critical role in the induction of HDM (zeige HDAC3 ELISA Kits)-induced allergic airway inflammation by inducing the expression of chemokine/chemokine (zeige CCL1 ELISA Kits) receptors in DCs.
The sum of the data suggests that in contrast to IgG-based immune complexes boosting immune reactivity of antigen-presenting cells, secretory IgA produced during an ongoing immune response can, in addition to its known function of immune exclusion, modulate mucosal dendritic cell conditioning via specific interaction with Dectin-1 and SIGNR3.
data suggest that the C-Type lectin receptor (zeige CLEC4D ELISA Kits) Dectin-1 is a major pattern recognition receptor that orchestrates miR155 upregulation in a Syk (zeige SYK ELISA Kits)-dependent manner; results suggest that PRR (zeige PVRL1 ELISA Kits)-mediating signaling events are key drivers of miRNA-mediated gene regulation during fungal pathogenesis
results strongly suggest that Ae2 (zeige SLC4A2 ELISA Kits) is a critical factor in the innate response to C. albicans. This study represents an important contribution to a better understanding of how Dectin-1 expression and fungal clearance is regulated.
Unique cytokine secretion and varying expression levels of n Dectin-1 isoforms on monocyte-derived cells may indicate distinct isoform usage as a cell type-specific mechanism of regulating anti-fungal immunity.
Dectin 1 is highly expressed on macrophages in pancreatic ductal adenocarcinoma.
Dectin-1-mediated activation of the Syk (zeige SYK ELISA Kits), MAPKs, PI3K (zeige PIK3CA ELISA Kits) and NF-kappaB (zeige NFKB1 ELISA Kits) signaling pathways contributes to F. proliferatum-stimulated CXCL-8 (zeige IL8 ELISA Kits) release from BEAS-2B cells and provides an important basis for developing novel therapeutic strategies in clinical allergy.
this study shows that curdlan inhibits tumor growth via activating dendritic cells through dectin-1 signaling
Dectin-1 is essential for efficient immune response against Mycobacteria.
dectin-1 has a role in glycyrrhetinic acid inhibition of contact hypersensitivity induced by trichophytin
study represents the first analysis demonstrating that harbouring polymorphisms of Dectin-1 (rs7309123) or TLR2 (zeige TLR2 ELISA Kits) (rs5743708) represents an independent risk factor of developing IFD in patients with AML (zeige RUNX1 ELISA Kits) undergoing induction chemotherapy.
TREM-1 (zeige TREM1 ELISA Kits) and Dectin-1 function concurrently in the corneal innate immune response by regulating inflammatory cytokine expression in fungal keratitis.
Our data suggest that the genetic diversity of CLEC7A gene influences the autism spectrum disorders (ASD (zeige ARSD ELISA Kits)) phenotype by behaving as a disease specifier and imply that the genetic control of innate immune response could determine the ASD (zeige ARSD ELISA Kits) phenotype.
CLEC7a genetic variant c.589A>G was significantly associated (p = 0.008) with Mycobacterium avium ssp. paratuberculosis infection in Holsteins cattle.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
dendritic cell-associated C-type lectin 1
, C-type lectin domain family 7, member A
, C-type lectin domain family 7 member A
, dectin 1
, C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12
, C-type lectin superfamily member 12
, DC-associated C-type lectin 1
, beta-glucan receptor
, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12
, dendritic cell-associated C-type lectin-1
, lectin-like receptor 1