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Mouse (Murine) Cathepsin S Protein expressed in Human Cells - ABIN3216406
Wiederanders, Brömme, Kirschke, von Figura, Schmidt, Peters: Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S. in The Journal of biological chemistry 1992
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Human Cathepsin S Protein expressed in Human Cells - ABIN2002951
Shi, Webb, Foster, Knoll, Lemere, Munger, Chapman: Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. in The Journal of biological chemistry 1994
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This study suggested serum Cat S may be a potential biomarker for the diagnosis and prognosis of gastric cancer
Overall, these results indicate that exploitation of the cathepsin S activity in MPS tissues can be utilized to substantially lower non-target accumulation, suggesting this is a promising approach for the development of diagnostic and radiotherapeutic nanomedicine platforms.
polymorphism of rs7534124 and rs1136774 in cathepsin S promoter may decrease the susceptibility of asthma in a Chinese Han population
cathepsin S mRNA (CTSS), which encodes a cysteine protease (zeige CTSB Proteine) associated with angiogenesis and atherosclerosis, is highly edited in human endothelial cells. RNA editing enables the recruitment of the stabilizing RNA-binding protein (zeige PTBP1 Proteine) human antigen R (HuR (zeige ELAVL1 Proteine); encoded by ELAVL1 (zeige ELAVL1 Proteine)) to the 3' UTR of the CTSS transcript, thereby controlling CTSS mRNA stability and expression.
levels of cathepsin S and hsCRP observed in women who later developed breast cancer may provide prognostic information regarding tumor development and need to be evaluated in prospective studies.
p41 (zeige EPB41 Proteine) fragment is also shown to reduce the secretion of interleukin-12 (IL-12 (zeige IL12A Proteine)/p70 (zeige ANXA6 Proteine)) during the subsequent maturation of treated dendritic cells.
shedding of surface proteins by extracellular cathepsins impacts intracellular signaling as demonstrated for regulation of Ras GTPase (zeige RACGAP1 Proteine) activity.
the essential role of autophagy-regulated early ROS (zeige ROS1 Proteine) in triggering late apoptotic signaling
Cathepsin S cleaves near the N-terminus of PAR2 (zeige F2RL1 Proteine) to expose a novel tethered ligand, KVDGTS.
Increased plasma CTSS concentration is associated with atherogenesis.
the roles of CTSB (zeige CTSB Proteine)/S and SIRT1 (zeige SIRT1 Proteine) in the regulation of hepatic inflammation using primary parenchymal and non-parenchymal hepatic cell types and cell lines.
Cathepsin S activity controls injury-related vascular remodeling via TLR2/p38MAPK (zeige MAPK14 Proteine)/PI3K/Akt (zeige AKT1 Proteine)/p-HDAC6 (zeige HDAC6 Proteine) signaling pathway.
Loss of Rab3D (zeige RAB3D Proteine) from secretory vesicles, leading to disproportionate Rab27 (zeige RAB27A Proteine)-to-Rab3D (zeige RAB3D Proteine) activity, may contribute to the enhanced release of cathepsin S in tears of patients with Sjogren's syndrome.
Ctss induction during muscular dystrophy is a pathologic event that partially underlies disease pathogenesis, and its inhibition might serve as a new therapeutic strategy in Duchenne muscular dystrophy (zeige DMD Proteine).
Demonstrate the utility of intracellular caspase 1 (zeige CASP1 Proteine) and extracellular CTSS proteolytic activities as surrogate biomarkers of lysosomal rupture and acute inflammation.
Fluorogen substrate, Mca (zeige RSPH1 Proteine)-GRWPPMGLPWE-Lys (zeige LYZ Proteine)(Dnp)-DArg-NH2 can detect CTSS activities in mouse antigen presenting cells.
Data show that cathepsins S (CatS) regulates CCL2 (zeige CCL2 Proteine) chemokine (zeige CCL1 Proteine) expression by modulation of CD74 (zeige CD74 Proteine) antigen processing.
Cathepsin S activates MrgprC11 (zeige MRGPRX1 Proteine) and evokes receptor-dependent scratching in mice.
cathepsin S deficiency alters the balance between adipocyte and osteoblast differentiation, increases bone turnover, and changes bone microarchitecture. Therefore, bone and fat metabolisms should be monitored when using cathepsin S inhibitors clinically
results identify Cat-S as a biased agonist of PAR2 (zeige F2RL1 Proteine) that causes PAR2 (zeige F2RL1 Proteine)- and TRPV4 (zeige TRPV4 Proteine)-dependent inflammation and pain.
The cathepsin S deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, cathepsin S
, cathepsin S, gene 1
, Cathepsin S