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results show that ligand binding to BTN3A1 induces a conformational change within the intracellular domain that involves the JM region and is required for full activation.
findings show that changes in the juxtamembrane domain of BTN3A1, but not its transmembrane domain, induce a markedly enhanced or reduced gammadelta T cell reactivity
These findings support intracellular sensing of prenyl pyrophosphates by BTN3A1 rather than extracellular presentation.
Human gamma-delta T cells are activated by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin (zeige PPL Proteine).
evidence that gene(s) on Chr6 in addition to BTN3A1 are mandatory for PAg (zeige PRDX1 Proteine)-mediated activation of Vgamma9Vdelta2 T cells.
Ligand binding to the BTN3A1 B30.2 domain affects residues in the juxtamembrane region, suggesting ligand-induced conformational change.
These studies demonstrate that internal sensing of changes in pAg (zeige PRDX1 Proteine) metabolite concentrations by BTN3A1 molecules is a critical step in Vgamma9Vdelta2 T cell detection of infection and tumorigenesis.
BTN3A1 represents an antigen-presenting molecule required for the activation of Vgamma9Vdelta2 T cells.
investigation of role of CD277 in activation/inactivation of T-lymphocytes: Data indicate that modulation of CD277 interaction (with agonists or blocking antibodies) with T-cell antigen receptor can modulate activation/inactivation of T-lymphocytes.
BTN3A1 is necessary for Vgamma9Vdelta2 activation and begin to unravel the extracellular events that occur during stimulation through the Vgamma9Vdelta2 T cell receptor.
The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1\\\\; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010
butyrophilin subfamily 3 member A1
, dJ45P21.3 (butyrophilin, subfamily 3, member A1)
, butyrophilin, subfamily 3, member A1
, butyrophilin subfamily 3 member A1-like