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Genes encoding butyrophilin-2A2 (BTN2A2) are reg (zeige CD4 Proteine)ulated by t (zeige CD8A Proteine)he class II trans-activator and re (zeige CD4 Proteine)gulatory factor X, two transcription factors dedicated to major histocompatibility complex class II expression, suggesting a role in T cell immunity.
Btn2a2(-/-) mice exhibited enhanced effector CD4 (zeige CD4 Proteine)(+) and CD8 (zeige CD8A Proteine)(+) T cell responses, impaired CD4 (zeige CD4 Proteine)(+) regulatory T cell induction, potentiated antitumor responses, and exacerbated experimental autoimmune encephalomyelitis.
Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
butyrophilin, subfamily 2, member A2
, butyrophilin 2
, butyrophilin subfamily 2 member A2