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The current study provides evidence for a possible association of renin gene polymorphisms with essential hypertension in a Han population of northern China.
Plasma renin activity is associated with cardiovascular mortality or heart failure readmissions.
In patients with established atherosclerotic disease undergoing carotid endarterectomy, plasma renin and aldosterone concentrations were not associated with atherosclerotic plaque characteristics. Plasma renin concentration was positively associated with the occurrence of major secondary vascular events.
These observations demonstrate that activation of the renin-angiotensin system (RAS) promotes colitis in a blood pressure independent manner. Angiotensin II appears to drive colonic mucosal inflammation by promoting intestinal epithelial cell apoptosis and mucosal TH17 responses in colitis development
The genotypes of REN, AT1R (zeige AGTR1 Proteine) and AT2R (zeige AGTR2 Proteine) were not associated with the development of preeclampsia in South African Black women.
Urinary angiotensinogen (zeige AGT Proteine) and renin excretion are elevated in CKD patients. Both parameters are negatively associated with eGFR (zeige EGFR Proteine) and these associations are independent of urinary albumin (zeige ALB Proteine) excretion
Autosomal dominant polycystic kidney disease (ADPKD), uniquely increases urinary angiotensinogen (zeige AGT Proteine) and renin excretion despite their circulating levels being comparable with those in non-ADPKD chronic kidney disease.
Prospective study of consecutive cardiac disease patients referred for cardiac catheterization has revealed distinct cardiac disease condition-associated differences in the frequencies of elevations in plasma renin, plasma aldosterone concentration, and the aldosterone-renin ratio
Renin-angiotensin system transgenic mouse model suggests that renal injury in preeclampsia may be mediated through local VEGF (zeige VEGFA Proteine).
Data suggest mild primary aldosteronism (PA), where plasma renin activity is not as suppressed, is susceptible to dietary sodium influences on renin and ARR (zeige SAG Proteine) (aldosterone to renin ratio). Optimal screening for PA should occur under conditions of high dietary sodium intake (rather than condition of low dietary sodium intake as frequently prescribed for patients with hypertension, which may be a symptom of PA).
Demonstrate substantive conservation of renin regulation across vertebrates, and ultrastructural studies of renin cells reveal at least two distinct morphologies of mesonephric perivascular renin-expressing cells.
Notch (zeige NOTCH1 Proteine) signaling and the endothelium are essential for developmental renin expression
first identification of renin gene sequences in zebrafish and the confirmation of renin gene expression in association with zebrafish pronephric and opisthonephric kidneys
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
, renin precursor, renal
, renin 1 structural
, cathepsin E