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Results show negative regulation of HDAC1 (zeige HDAC1 Proteine) by a Cul3 (zeige CUL3 Proteine)-REN E3 ubiquitin ligase (zeige MUL1 Proteine) complex.
REN is upregulated by neurogenic signals (retinoic acid, EGF (zeige EGF Proteine), and NGF (zeige NGFB Proteine)) in embryonal stem (ES) cells and neural progenitor cell lines in association with neurotypic differentiation.
REN protein enhances caspase-3 (zeige CASP3 Proteine) activation and antagonizes the Shh (zeige SHH Proteine) pathway suggesting that this gene may represent a restraint of Shh (zeige SHH Proteine) signaling.
These observations demonstrate that activation of the renin-angiotensin system (RAS) promotes colitis in a blood pressure independent manner. Angiotensin II appears to drive colonic mucosal inflammation by promoting intestinal epithelial cell apoptosis and mucosal TH17 responses in colitis development
The genotypes of REN, AT1R (zeige AGTR1 Proteine) and AT2R (zeige AGTR2 Proteine) were not associated with the development of preeclampsia in South African Black women.
Urinary angiotensinogen (zeige AGT Proteine) and renin excretion are elevated in CKD patients. Both parameters are negatively associated with eGFR (zeige EGFR Proteine) and these associations are independent of urinary albumin (zeige ALB Proteine) excretion
Autosomal dominant polycystic kidney disease (ADPKD), uniquely increases urinary angiotensinogen (zeige AGT Proteine) and renin excretion despite their circulating levels being comparable with those in non-ADPKD chronic kidney disease.
Prospective study of consecutive cardiac disease patients referred for cardiac catheterization has revealed distinct cardiac disease condition-associated differences in the frequencies of elevations in plasma renin, plasma aldosterone concentration, and the aldosterone-renin ratio
Renin-angiotensin system transgenic mouse model suggests that renal injury in preeclampsia may be mediated through local VEGF (zeige VEGFA Proteine).
Data suggest mild primary aldosteronism (PA), where plasma renin activity is not as suppressed, is susceptible to dietary sodium influences on renin and ARR (zeige SAG Proteine) (aldosterone to renin ratio). Optimal screening for PA should occur under conditions of high dietary sodium intake (rather than condition of low dietary sodium intake as frequently prescribed for patients with hypertension, which may be a symptom of PA).
This study demonstrates the efficacy of aldosterone/direct renin concentration ratio as a screening test for primary aldosteronism.
The dominant model (CC vs. CT+TT) of rs1894111 polymorphism in the ADRBK1 gene might be associated with low-renin hypertension in Han Chinese.
Data show that the optimum time for beta-adrenoreceptor antagonists (beta-blockers) withdrawal was 2 weeks when using direct renin concentration (DRC (zeige FECH Proteine)) and 3 weeks for plasma renin activity (PRA (zeige S100A6 Proteine)).
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
, BTB/POZ domain-containing protein KCTD11
, retinoic acid, EGF, and NGF upregulated
, renin 1 structural
, angiotensin-forming enzyme
, renin precursor, renal