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General |
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Antigen | Nanos Homolog 3 (NANOS3) Antikörper |
Epitop | C-Term Alternativen |
Reaktivität | Human, Maus, Ratte (Rattus) Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Dieser NANOS3 Antikörper ist unkonjugiert Alternativen |
Applikation |
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternativen
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Hersteller | Anmelden zum Anzeigen |
Produktdetails anti-NANOS3 AntikörperTarget Details NANOS3 Anwendungsinformationen Handhabung Bilder |
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Spezifität | This antibody detects Nanos3 at C-term. It will not cross-react with either Nanos 1 or Nanos2. |
Kreuzreaktivität (Details) | Species reactivity (tested):Human, mouse, rat |
Reinigung | Peptide affinity chromatography |
Immunogen | Nanos3 antibody was raised against a 16 amino acid peptide near the carboxy terminus of the human Nanos3. |
Isotyp | IgG |
Plasmids, Primers & others | |
Target Details NANOS3Produktdetails anti-NANOS3 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | NANOS3 (NANOS3 Antibody Abstract) |
Hintergrund | Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3-null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3-null background. Nanos3 expression can not rescue Nanos2-null defects.Synonyms: MGC120114, NANOS1L, NOS3, Nanos homolog 3 |
Gen-ID | 342977 |
NCBI Accession | NP_001092092 |
UniProt | Q495E5 |
Pathways | ACE Inhibitor Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Response to Molecule of Bacterial Origin, Myometrial Relaxation and Contraction, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling |
AnwendungsinformationenProduktdetails anti-NANOS3 Antikörper Target Details NANOS3 Handhabung Bilder zurück nach oben |
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Applikations-hinweise |
ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails anti-NANOS3 Antikörper Target Details NANOS3 Anwendungsinformationen Bilder zurück nach oben |
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Buffer | PBS containing 0.02 % sodium azide |
Konservierungs-mittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Avoid repeated freezing and thawing. |
Lagerung | 4 °C/-20 °C |
Informationen zur Lagerung | Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. |