omega-conotoxin MVIIC (omega contoxin MVIIC)
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- Target
- Conotoxin MVIIC omega
- Applikation
- Blocking Reagent (BR)
- Verwendungszweck
- omega-conotoxin MVIIC is a calcium channel blocker
- Sequenz
- Cys1-Lys-Gly-Lys-Gly-Ala-Pro-Cys8-Arg-Lys-Thr-Met-Tyr-Asp-Cys15-Cys16-Ser-Gly-Ser-Cys20-Gly-Arg-Arg-Gly-Lys-Cys26-NH2Disulfide bonds between Cys1-Cys16, Cys8-Cys20and Cys15-Cys26
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Target
- Conotoxin MVIIC omega
- Hintergrund
- Omega-conotoxin MVIIC has been isolated from the venom of the cone Conus magus. omega-conotoxin MVIIC inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of omega-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. omega-conotoxin MVIIC also presents an inhibition of omega-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats.
- Molekulargewicht
- 2750.2 Da
- CAS-Nummer
- 147794-23-8
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