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TDP2 encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. Zusätzlich bieten wir Ihnen TDP2 Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 88 products:
Human Polyclonal TDP2 Primary Antibody für IF, WB - ABIN526818
Thomson, Watson, Caldecott, Denneny, Depledge, Hamilton, Hopkins, Jordan, Morrow, Raoof, Waddell, Ogilvie: Generation of assays and antibodies to facilitate the study of human 5'-tyrosyl DNA phosphodiesterase. in Analytical biochemistry 2013
Human Polyclonal TDP2 Primary Antibody für ICC, IF - ABIN4309668
Virgen-Slane, Rozovics, Fitzgerald, Ngo, Chou, van der Heden van Noort, Filippov, Gershon, Semler: An RNA virus hijacks an incognito function of a DNA repair enzyme. in Proceedings of the National Academy of Sciences of the United States of America 2012
Cow (Bovine) Polyclonal TDP2 Primary Antibody für IHC, WB - ABIN2777707
Pei, Yordy, Leng, Zhao, Watson, Li: EAPII interacts with ETS1 and modulates its transcriptional function. in Oncogene 2003
Show all 2 Pubmed References
TDP2 suppresses chromosome rearrangements induced by TOP2 (zeige TOP2A Antikörper) and reduces TOP2 (zeige TOP2A Antikörper)-induced chromosome translocations that arise during gene transcription.
Both the genome instability and cell death of MRE11 (zeige MRE11A Antikörper)-null and MRE11 (zeige MRE11A Antikörper)-mutated H129N cells are significantly reversed by overexpression of Tdp2, an enzyme that eliminates covalent Top2 (zeige TOP2A Antikörper) conjugates; thus, the essential role of Mre11 (zeige MRE11A Antikörper) nuclease (zeige DCLRE1C Antikörper) activity is likely to remove the DNA lesions.
Study revealed a post-translational regulation of TDP2 activity and discovered a new role of ERK3 (zeige MAPK4 Antikörper) in increasing cancer cells' DNA damage response and chemoresistance to Top2 (zeige TOP2A Antikörper) inhibitors.
Data show that DNA-repair enzyme (zeige LIG4 Antikörper) TDP2 knockdown in HepG2 cells significantly delays the conversion of relaxed circular DNA (RC-DNA) to covalently closed circular (ccc) DNA.
This article summarizes and compares the biochemistry, functions, and post-translational regulation of TDP1 (zeige TDP1 Antikörper) and TDP2, as well as the relevance of TDP1 (zeige TDP1 Antikörper) and TDP2 as determinants of response to anticancer agents
Proteolytic degradation of Top2 (zeige TOP2A Antikörper) enables the processing of Top2 (zeige TOP2A Antikörper).DNA and Top2 (zeige TOP2A Antikörper).RNA covalent complexes by TDP2.
TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
Mutations in the 5'-tyrosyl-DNA phosphodiesterase activity of TTRAP,in particular TTRAP(E152A), showed decreased inhibitory activity on cell growth.
Magnesium is indispensable for a 5'-tyrosyl DNA phosphodiesterase activity.
VPg unlinkase activity in different mammalian cell lines correlates with their differential expression of TDP2.
The results collectively provide a structural mechanism for Tdp2 engagement of heterogeneous DNA damage that causes Top2 (zeige TOP2 Antikörper) poisoning.
data show that TDP2 activity potentiates enterovirus infections and, in the case of coxsackievirus B3, is a required host function following virus infection of mouse cells
our data reveal TDP2-mediated error-free NHEJ as an efficient and accurate mechanism to repair TOP2 (zeige TOP2 Antikörper)-induced DSBs
Evidence implicates Tdp2 in the repair of Top1 (zeige TOP1 Antikörper)-mediated DNA damage in cultured cells and in vivo, in the absence of Tdp1 (zeige TDP1 Antikörper).
the protein associates with TGF-beta (zeige TGFB1 Antikörper) receptors and components of the TRAF6 (zeige TRAF6 Antikörper)-TAK1 (zeige NR2C2 Antikörper) signaling module
although the role of Smad (zeige SMAD1 Antikörper) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap provides insight into a novel Smad (zeige SMAD1 Antikörper) partner that plays an essential role in the fine-tuning of this signal transduction cascade
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
, 5'-tyrosyl-DNA phosphodiesterase
, ETS1-associated protein 2
, ETS1-associated protein II
, TRAF and TNF receptor associated protein
, TRAF and TNF receptor-associated protein
, VPg unlinkase
, tyr-DNA phosphodiesterase 2
, tyrosyl-RNA phosphodiesterase
, TRAF and TNF receptor-associated protein homolog
, Tyr-DNA phosphodiesterase 2
, Traf and Tnf receptor associated protein
, immune transcriptional repressor
, traf and tnf receptor associated protein, like
, tyrosyl-DNA phosphodiesterase 2