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SIGMAR1 encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. Zusätzlich bieten wir Ihnen SIGMAR1 Antikörper (36) und SIGMAR1 Kits (17) und viele weitere Produktgruppen zu diesem Protein an.
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These findings indicate that a loss of Sig1R function is causative for juvenile amyotrophic lateral sclerosis (ALS16), and collapse of the mitochondria-associated membrane is a common pathomechanism in both Sig1R- and SOD1-linked ALS.
Analyses of tissue microarray from colorectal cancer patients showed higher SigmaR1 expression levels in cancer samples and a correlation with tumor grade. Moreover, the exploration of a cohort of 4937 breast cancer patients indicated that high expression of SigmaR1 and Orai1 channels was significantly correlated to a lower overall survival.
Genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with Major Depressive Disorder and Bipolar Disorder.
Data demonstrate the involvement of SIGMAR1 in motor neuron maintenance and survival by correlating mutations in this gene to distal motor dysfunction and highlight the chaperone activity of sigma-1R as a critical aspect in distal hereditary motor neuropathy pathology.
Changes of Sig1R and SOD2 (zeige SOD2 Proteine) expression point to mitochondria as main organelle responsible for survival of tumor cells exposed to hypoxia or oxidative stress. Studied proteins are involved in intracellular response to stress related with different concentrations of oxygen.
Collectively, these studies define Sig1R as a key mediator of TRAIL induction of cancer-specific killing.
crystal structures of the human sigma1 receptor in complex with two chemically divergent ligands, PD144418 and 4-IBP (zeige TSPO Proteine)
Expression of mutant Sig-1R protein reduces mitochondrial ATP production, inhibits proteasome activity and causes mitochondrial injury, aggravating ER stress-induced neuronal death.
Removal of the S1R gene in the Superoxide Dismutase-1 (SOD-1 (zeige SOD1 Proteine)) mouse model of ALS (zeige IGFALS Proteine) exacerbated the neurodegenerative condition and resulted in a significantly reduced longevity.
mutations of the SIGMAR1 gene worsen outcome in Alzheimer's disease and myotrophic lateral sclerosis supporting a role of Sig-1R in neurodegenerative disease.
Results indicate that the sigma1R deficiency in basolateral amygdala principal neurons via NMDA recetpor dysfunction suppresses nNOS (zeige NOS1 Proteine) activity and NO production to reduce GABA-A receptor-mediated inhibition, which impairs long-term depression induction and causes depressive-like phenotype.
Sigma 1 receptor (Sig1R) activation modifies intracellular calcium exchange in the G93A(hSOD1 (zeige SOD1 Proteine)) amyotrophic lateral sclerosis model. Study shows, intracellular Ca(2 (zeige CA2 Proteine)+) shuttling can be manipulated by Sig1R activation.
Chronic pharmacological stimulation of sigma1rs induces learning and memory behavioral improvement in an ischemia model. Significant neurorestorative effects may be favored by a BDNF (zeige BDNF Proteine) neurotrophic effect. The involvement of an antagonist of NR2A (zeige GRIN2A Proteine) revealed that the improvement of learning and memory impairment, mediated by BDNF (zeige BDNF Proteine) through sigma1r activation, relied on the NR2A (zeige GRIN2A Proteine)-induced CaMKIV (zeige CAMK4 Proteine)-TORC1 (zeige CRTC1 Proteine)-p-CREB (zeige CREB1 Proteine) pathway.
Sig1R activation preserves retinal thickness and diminishes retinal detachment in Pde6beta mutant mice.
Methamphetamine induced microglial apoptosis via its cognate receptor sigma-1R. Furthermore, this effect was mediated by activation of MAPKs and PI3K/Akt (zeige AKT1 Proteine) pathways and subsequent translocation of p53 (zeige TP53 Proteine) into nucleus, resulting in activation of caspase (zeige CASP3 Proteine), ultimately leading to cell apoptosis. sigma-1R plays a critical role in eliciting innate immune responses in microglia.
Findings identified five alternatively spliced variants of the sigma1 receptor gene Sigmar1 using a polymerase chain reaction cloning approach.
inhibition of Sig (zeige PICALM Proteine)-1 R prevented cocaine-induced TrkB (zeige NTRK2 Proteine) activation in hippocampal neurons.
Activation of S1R, necessary for its effect on the BDNF pathway, represents a core component of the mode of action of pridopidine. Since the newly identified pathways are downregulated in neurodegenerative diseases, including Huntington Disease (HD) , these findings suggest that pridopidine may exert neuroprotective effects beyond its role in alleviating some symptoms of HD.
Findings demonstrate that spinal cord injury activates astrocyte sigma-1 receptors leading to increases in the expression of the gap junction protein, connexin 43 (zeige GJA1 Proteine) and astrocyte activation in the lumbar dorsal horn, and ultimately contribute to the induction of bilateral below-level mechanical allodynia.
Study found: sigma-1 receptor is abundant in dorsal root ganglion (DRG) neuronal soma, but not in satellite cells; sigma-1 receptor is absent in processes of DRG neurons; in DRG neurons, S1R targets endoplasmic reticulum, nuclear envelope, and plasma membrane.
Sig1R through Rac1 signaling induces mild oxidative stress that possibly is involved in the regulation of neuroplasticity
S1R has a GXXXG motif in its second transmembrane region, and these motifs are often involved in oligomerization of membrane proteins. Disrupting mutations within the GXXXG motif shifted the fraction of the higher oligomeric states toward smaller states.
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor\; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.
SR31747 binding protein 1
, aging-associated gene 8 protein
, sigma 1-type opioid receptor
, opioid receptor, sigma 1
, Sigma 1-type opioid receptor
, sigma1-receptor (sterol-isomerase like protein)
, sterol isomerase-like protein