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SIGMAR1 encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. Zusätzlich bieten wir Ihnen SIGMAR1 Antikörper (47) und SIGMAR1 Kits (20) und viele weitere Produktgruppen zu diesem Protein an.
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Disruption of the association of Sig-1R with TRPV1 (zeige TRPV1 Proteine) by synthetic or natural antagonists leads to degradation of TRPV1 (zeige TRPV1 Proteine) protein and to decreased levels of the ion channel protein (zeige TRPC3 Proteine) as well as to a decrease in TRPV1 (zeige TRPV1 Proteine)-associated pain.
Findings indicate that sigma1R is decreased in hepatocellular carcinoma and is closely correlated with histological differentiation.
These findings indicate that a loss of Sig1R function is causative for juvenile amyotrophic lateral sclerosis (ALS16), and collapse of the mitochondria-associated membrane is a common pathomechanism in both Sig1R- and SOD1-linked ALS.
Analyses of tissue microarray from colorectal cancer patients showed higher SigmaR1 expression levels in cancer samples and a correlation with tumor grade. Moreover, the exploration of a cohort of 4937 breast cancer patients indicated that high expression of SigmaR1 and Orai1 channels was significantly correlated to a lower overall survival.
Genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with Major Depressive Disorder and Bipolar Disorder.
Data demonstrate the involvement of SIGMAR1 in motor neuron maintenance and survival by correlating mutations in this gene to distal motor dysfunction and highlight the chaperone activity of sigma-1R as a critical aspect in distal hereditary motor neuropathy pathology.
Changes of Sig1R and SOD2 (zeige SOD2 Proteine) expression point to mitochondria as main organelle responsible for survival of tumor cells exposed to hypoxia or oxidative stress. Studied proteins are involved in intracellular response to stress related with different concentrations of oxygen.
Collectively, these studies define Sig1R as a key mediator of TRAIL induction of cancer-specific killing.
crystal structures of the human sigma1 receptor in complex with two chemically divergent ligands, PD144418 and 4-IBP (zeige TSPO Proteine)
Expression of mutant Sig-1R protein reduces mitochondrial ATP production, inhibits proteasome activity and causes mitochondrial injury, aggravating ER stress-induced neuronal death.
Oprs1 neuroprotective effect has been demonstrated in a cell model of Huntington's disease.
This study reveals previously uncharacterized S1R-associated mechanisms during rd10 (zeige PDE6B Proteine) photoreceptor degeneration
l-THP (zeige UMOD Proteine) possesses antinociceptive effects through spinal Sig-1R mechanism and may be a useful analgesic in the management of neuropathic pain
Results indicate that the sigma1R deficiency in basolateral amygdala principal neurons via NMDA recetpor dysfunction suppresses nNOS (zeige NOS1 Proteine) activity and NO production to reduce GABA-A receptor-mediated inhibition, which impairs long-term depression induction and causes depressive-like phenotype.
Sigma 1 receptor (Sig1R) activation modifies intracellular calcium exchange in the G93A(hSOD1 (zeige SOD1 Proteine)) amyotrophic lateral sclerosis model. Study shows, intracellular Ca(2 (zeige CA2 Proteine)+) shuttling can be manipulated by Sig1R activation.
Chronic pharmacological stimulation of sigma1rs induces learning and memory behavioral improvement in an ischemia model. Significant neurorestorative effects may be favored by a BDNF (zeige BDNF Proteine) neurotrophic effect. The involvement of an antagonist of NR2A (zeige GRIN2A Proteine) revealed that the improvement of learning and memory impairment, mediated by BDNF (zeige BDNF Proteine) through sigma1r activation, relied on the NR2A (zeige GRIN2A Proteine)-induced CaMKIV (zeige CAMK4 Proteine)-TORC1 (zeige CRTC1 Proteine)-p-CREB (zeige CREB1 Proteine) pathway.
Sig1R activation preserves retinal thickness and diminishes retinal detachment in Pde6beta mutant mice.
Methamphetamine induced microglial apoptosis via its cognate receptor sigma-1R. Furthermore, this effect was mediated by activation of MAPKs and PI3K/Akt (zeige AKT1 Proteine) pathways and subsequent translocation of p53 (zeige TP53 Proteine) into nucleus, resulting in activation of caspase (zeige CASP3 Proteine), ultimately leading to cell apoptosis. sigma-1R plays a critical role in eliciting innate immune responses in microglia.
Findings identified five alternatively spliced variants of the sigma1 receptor gene Sigmar1 using a polymerase chain reaction cloning approach.
Sig1R through Rac1 signaling induces mild oxidative stress that possibly is involved in the regulation of neuroplasticity
S1R has a GXXXG motif in its second transmembrane region, and these motifs are often involved in oligomerization of membrane proteins. Disrupting mutations within the GXXXG motif shifted the fraction of the higher oligomeric states toward smaller states.
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor\; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.
SR31747 binding protein 1
, aging-associated gene 8 protein
, sigma 1-type opioid receptor
, opioid receptor, sigma 1
, Sigma 1-type opioid receptor
, sigma1-receptor (sterol-isomerase like protein)
, sterol isomerase-like protein