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SGK3 is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. Zusätzlich bieten wir Ihnen serum/glucocorticoid Regulated Kinase Family, Member 3 Antikörper (127) und und viele weitere Produktgruppen zu diesem Protein an.
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Mechanism of activation of SGK3 by IGF1 (zeige IGF1 Proteine) via the class 1 and class 3 phosphatidylinositol 3-kinases has been described.
Hence, we concluded that miR1443p, which is frequently downregulated in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) can inhibit proliferation, migration and repress angiogenesis by regulating SGK3 activation with PI3K (zeige PIK3CA Proteine) independent signal pathway, and acts as a prognostic factor for HCC (zeige FAM126A Proteine) patients.
SGK3 a kinase transcriptionally regulated by estrogen receptor alpha (ERalpha (zeige ESR1 Proteine)) in breast cancer, sustains ERalpha (zeige ESR1 Proteine) signaling and drives the acquired aromatase (zeige CYP19A1 Proteine) inhibitors resistance by protecting against endoplasmic reticulum (EnR (zeige LARGE Proteine)) stress-induced ERalpha (zeige ESR1 Proteine) downregulation and cell death through preserving SERCA2b (zeige ATP2A2 Proteine) function.
High SGK3 expression is associated with epithelial-mesenchymal transition in hepatocellular carcinoma.
These findings highlight the importance of the hVps34 (zeige PIK3C3 Proteine)-SGK3 pathway in counteracting inhibition of PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signalling.
Data show that activation of serum- and glucocorticoid-regulated kinase 3 (SGK3) plays an important role in inositol polyphosphate 4-phosphatase type II (INPP4B (zeige INPP4B Proteine))-mediated melanoma cell proliferation.
It is unlikely that SGK3 plays a significant role for oncogenic signalling in multiple myeloma.
SGK3 is a key mediator of PDK1 (zeige PDK1 Proteine) activity in melanoma.
VPS34 (zeige PIK3C3 Proteine)-IN1 will provide a useful tool to decipher the kinase-dependent functions of Vps34 (zeige PIK3C3 Proteine), with acute changes in SGK3 phosphorylation and subcellular localization being new biomarkers of Vps34 (zeige PIK3C3 Proteine) activity
Breast cancers harboring oncogenic PIK3CA (zeige PIK3CA Proteine) activate SGK3 signaling while suppressing Akt (zeige AKT1 Proteine), indicative of oncogenic functions for both INPP4B (zeige INPP4B Proteine) and SGK3 in these tumors.
SGK1 (zeige SGK1 Proteine) and SGK3 are expressed in multiple microglial cell lines. SGK1 (zeige SGK1 Proteine) and SGK3 may play an important role in regulating microglial viability and inflammatory responses.
SGK3 is a positive regulator of KCNA5 (zeige KCNA5 Proteine), which is at least partially effective by abrogating the effect of Nedd4-2 (zeige NEDD4L Proteine).
SGK3 contributes to the regulation of store-operated calcium entry into and migration of dendritic cells.
SGK3 plays a previously unappreciated role in glucose homeostasis, likely through direct effects within pancreatic beta-cells, to stimulate proliferation and insulin (zeige INS Proteine) release
The study identifies SGK3 as a novel endosomal kinase that acutely regulates Na(+)/H(+) exchanger 3 (NHE3 (zeige SLC9A3 Proteine)) in a PI3K-dependent mechanism.
SGK3 has a subtle but significant role in the regulation of renal tubular phosphate transport and bone density.
Data suggest that SGK3 is critical for proper mast cell function.
SGK3 plays an important role in postnatal hair follicle development as illustrated by SGK3 knockout mice. The hair defect is linked to reduced proliferation and reduced nuclear accumulation of beta catenin (zeige CTNNB1 Proteine) in hair bulb keratinocytes.
SGK3 is differentially regulated in hippocampus after contextual fear conditioning & reactivation of the context-shock memory. Consolidation changes are recapitulated during reconsolidation. Retrieval-induced transcription depends on memory remoteness.
SGK3, and to a lesser extent SGK2 (zeige SGK2 Proteine), but not SGK1 (zeige SGK1 Proteine), increase glutamate (zeige GRIN1 Proteine)-induced currents by increasing the abundance of GluR1 (zeige GRIA1 Proteine) protein in the cell membrane
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
cytokine-independent survival kinase
, serine/threonine-protein kinase Sgk3
, serine/threonine protein kinase CISK
, serum/glucocorticoid-regulated kinase 3
, serum/glucocorticoid regulated kinase 3
, serum glucocorticoid regulated kinase 3