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The protein encoded by SERPINA10 belongs to the serpin family. Zusätzlich bieten wir Ihnen serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 Kits (26) und serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 10 Proteine (14) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SERPINA10 Primary Antibody für ELISA, WB - ABIN408725
Han, Fiehler, Broze: Characterization of the protein Z-dependent protease inhibitor. in Blood 2000
Show all 2 Pubmed References
Letter: ZPI is a typical acute phase reactant.
structural features within residues of the 39-loop contribute to the resistance of FIXa (zeige ETFB Antikörper) to inhibition by plasma inhibitors ZPI and TFPI (zeige TFPI Antikörper).
PZ and ZPI deficiency would be associated with a modest thrombotic risk with ZPI deficiency producing a more severe phenotype.
Data suggest oxidized lipid vesicles with phosphatidylserine/polyunsaturated fatty acids promote inactivation of ZPI-PZ complex or free ZPI; binding of PZ-complexed or free ZPI to oxidized vesicles mediates inactivation of ZPI (an inhibitor of FXa (zeige F10 Antikörper)); blocking heparin- (anticoagulant-)binding site on ZPI interferes with binding to lipid or PZ. (ZPI = protein Z-dependent protease inhibitor; PZ = protein Z (zeige PROZ Antikörper); FXa (zeige F10 Antikörper) = factor Xa (zeige F10 Antikörper))
Results show the energetic basis of the Z-dependent protease inhibitor (ZPI)-protein Z (zeige PROZ Antikörper) (PZ) interaction and suggest an important role for ZPI Lys (zeige LYZ Antikörper)-239 in PZ catalytic action.
The unbalance between PZ and ZPI in plasma samples from patients with Colorectal Cancer or Pancreatic Cancer is not only related to an inflammatory state but could also results from an ectopic synthesis of these proteins by the cancer cells.
Protein Z (zeige PROZ Antikörper) EGF2 subdomain constitutes an interactive-site for ZPI protein.
Protein Z/protein Z (zeige PROZ Antikörper)-dependent protease inhibitor and Fxa (zeige F10 Antikörper) expression in human gastric cancer cells indicate that these proteins may play a role in anticoagulant events at the tumor tissue.
the PZ/ZPI complex may play some modulating role in hemophilia A
The study shows by Ala-scanning mutagenesis of the ZPI-binding interface, together with native PAGE and kinetic analyses of PZ binding to ZPI, that Tyr240 and Asp293 of ZPI are crucial hot spots for PZ binding.
Report two missense mutations identified in venous thrombosis patients impair the inhibitory function of the ZPI were not convincingly associted with thrombosis risk.
heparin-binding site of ZPI was mapped: basic residues of both helices C and D of ZPI interact with heparin to modulate the inhibitory function of the serpin.
The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
, Protein Z-dependent protease inhibitor
, protein Z-dependent protease inhibitor-like
, PZ-dependent protease inhibitor
, protein Z-dependent protease inhibitor
, serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
, serpin A10
, plasma protein associated with liver regeneration
, regeneration-associated serpin 1
, serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
, serpin peptidase inhibitor, clade A, member 10