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The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. Zusätzlich bieten wir Ihnen serine/threonine Kinase 24 Antikörper (93) und serine/threonine Kinase 24 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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High MST3 expression is associated with breast cancer.
This study demonistrated that MST3 kinase phosphorylates TAO1 (zeige TAOK2 Proteine)/2 to enable Myosin Va (zeige MYO5A Proteine) function in promoting spine synapse development.
This review notes that in the SOK1 (zeige STK25 Proteine) and MST4 (zeige MST4 Proteine) germinal center kinase (zeige MAP4K2 Proteine) III family of proteins, exon 1 encodes a 5' untranslated region, but this is not the case for MST3.
These data provide molecular understanding of the mechanism by which MO25 (zeige CAB39 Proteine) isoforms regulates the activity of STE20 family protein kinases.
results show that a STRADalpha-rac1-PAK1 (zeige PAK1 Proteine) pathway regulates cell polarity and invasion in LKB1 (zeige STK11 Proteine)-null cells. It also suggests that while the function of LKB1 (zeige STK11 Proteine) and STRADalpha undoubtedly overlap, they may also have mutually exclusive roles
mechanism of regulation of MST3
Striatin (zeige STRN Proteine) orchestrates the regulation of Mst3 by PP2A (zeige PPP2R4 Proteine).
Mst3 is up-regulated and plays an important role in hypoxia-induced apoptosis of human trophoblasts.
five crystal structures of the catalytic domain of MST3 are presented, including a complex with ADP and manganese, a unique cofactor preferred by the enzyme, and a complex with adenine.
Proteolytic activation of Mst3 by caspases.
MST3 inhibits the insulin (zeige INS Proteine) signalling pathway and is important in the development of insulin (zeige INS Proteine) resistance and impaired blood glucose levels after an HFD.
It is involved in apoptosis and serine/threonine kinase 3 (STK3 (zeige PKN1 Proteine)) is a recently identified caspase-6 (zeige CASP6 Proteine) substrate.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 (zeige MST1 Proteine) and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (zeige YAP1 Proteine) target genes and hepatocyte proliferation.
Studies indicate that Hippo (Hpo (zeige GFER Proteine); MST1 (zeige MST1 Proteine)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Mst2 (zeige STK3 Proteine) is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (zeige NFKB1 Proteine) pathway
the TLR-Mst1 (zeige MST1 Proteine)-Mst2 (zeige STK3 Proteine)-Rac (zeige AKT1 Proteine) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (zeige STK4 Proteine) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy
Phosphorylation of LC3 (zeige MAP1LC3A Proteine) by the STK3 (zeige PKN1 Proteine) and STK4 is essential for autophagy.
These results identify MST2 (zeige STK3 Proteine), not MST1 (zeige MST1 Proteine), as a critical regulator of caspase (zeige CASP3 Proteine)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
results reveal a novel role of Mst2 (zeige STK3 Proteine) in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart
CCM3 (zeige PDCD10 Proteine) signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.
Mst3b, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3b is activated in response to trophic factors, and suppressing its expression
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3\; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2\; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000
STE20-like kinase 3
, STE20-like kinase MST3
, mammalian STE20-like protein kinase 3
, serine/threonine kinase 24 (STE20 homolog, yeast)
, serine/threonine-protein kinase 24
, sterile 20-like kinase 3
, mammalian sterile twenty 3 kinase
, STE20-like kinase MST2
, mammalian STE20-like protein kinase 2
, protein kinase homolog
, serine/threonine-protein kinase 3
, serine/threonine kinase 24 (STE20 homolog)
, serine/threonine kinase 24 L homeolog