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The protein encoded by RHOBTB2 is a small Rho GTPase and a candidate tumor suppressor.
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these findings provide evidence that DBC2 suppresses tumorigenesis in breast cancer by ubiquitinating MSI2 (zeige MSI2 Proteine).
Mutation in the promoter and exon 7 of DBC2 gene is not common in the Chinese population and may not contribute to the susceptibility for breast cancer in China
data suggest a new paradigm for Hsp90 (zeige HSP90 Proteine)-modulated assembly of a Cul3 (zeige CUL3 Proteine)/DBC2 E3 ubiquitin ligase (zeige MUL1 Proteine) complex that may extend to other E3 ligase complexes.
). The results demonstrated that aberrant methylation of RhoBTB2 may be responsible for the suppression of RhoBTB2 mRNA expression in breast cancer, a significant event during the genesis of breast cancer that correlated with progesterone receptor (zeige PGR Proteine) status
Thus loss of DBC2 expression is caused by abnormal methylation of DBC2 and might have a role in breast cancer development.
Loss of DBC2 expression is an early and progressive event in the development of lung adenocarcinoma.
Overexpression of RhoBTB2 in breast tumor cells significantly inhibited the proliferation and colony formation of tumor cells. In addition, RhoBTB2 also elevated the apoptotic ratio and caused typical changes of apoptotic morphology.
RhoBTB2 is establishing itself as a tumor suppressor with increasing relevance towards malignancies.
Ectopic expression of RhoBTB2 results in decreased phosphorylation of ezrin (zeige EZR Proteine) and Akt2 (zeige AKT2 Proteine) in both MDA-MB-231 and MDA-MB-435 cells.
The expression of Fas (zeige FAS Proteine), CTLA-4 (zeige CTLA4 Proteine) and RhoBTB2 at the mRNA level is involved in genesis and progression of breast cancer.
There is no connection between elevated expression of mDbc2/Rhobtb2 and a specific stage of mammary gland development, but this gene plays a critical role in the development of the nervous system.
The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene.
deleted in breast cancer 2 gene protein
, rho-related BTB domain-containing protein 2
, Rho-related BTB domain containing 2
, rho-related BTB domain-containing protein 2-like
, deleted in breast cancer 2 gene protein homolog