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PEA15 encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Zusätzlich bieten wir Ihnen PEA15 Antikörper (132) und PEA15 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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Data suggest that PED has a prominent role in HCC (zeige FAM126A Proteine) biology. It acts particularly on promoting cell migration and confers resistance to sorafenib treatment.
PP4 (zeige ANXA5 Proteine) regulates breast cancer cell survival and identifies a novel PP4c (zeige PPP4C Proteine)-PEA15 signalling axis in the control of breast cancer cell survival.
PEA15 expression was not significantly correlated with ovarian cancer antineoplastic drug resistance.
Data suggest the role of the phospholipase C epsilon-Protein kinase D (zeige PRKD1 Proteine)-PEA15 protein-ribosomal S6 kinase (zeige RPS6KB1 Proteine)-IkappaB-NF-kappa B (zeige NFKB1 Proteine) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.
Integrin alpha5beta1 and p53 (zeige TP53 Proteine) convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin (zeige BIRC5 Proteine) in high-grade glioma.
High PED expression is associated with esophageal carcinoma.
The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.
Latent HCMV infection of CD34 (zeige CD34 Proteine) + cells protects cells from FAS (zeige FAS Proteine)-mediated apoptosis through the cellular IL-10 (zeige IL10 Proteine)/PEA-15 pathway.
New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.
PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism
PEA-15 is a protective mediator in the vasculature and acts, at least in part, by inhibiting ERK1/2-dependent nuclear signaling in vascular smooth muscle cells during neointimal hyperplasia.
Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.
Activated astrocytes are known to clear the Abeta (zeige APP Proteine) deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).
Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma (zeige PPARG Proteine)) represses transcription of the ped/pea-15 gene.
The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation.
PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3 (zeige PPP1R11 Proteine)-methyladenine rescued TGF-beta1 (zeige TGFB1 Proteine) effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 (zeige TGFB1 Proteine) effects in muscle.
Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2.
we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK (zeige MAPK1 Proteine) pathways under gonadotropin releasing hormone stimulation
PEA-15 regulates T-cell proliferation
This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.
15 kDa phosphoprotein enriched in astrocytes
, Phosphoprotein enriched in astrocytes, 15kD
, astrocytic phosphoprotein PEA-15
, homolog of mouse MAT-1 oncogene
, phosphoprotein enriched in diabetes
, mammary transforming gene 1
, phosphoprotein enriched in astrocytes 15
, phosphoprotein enriched in astrocytes 15A
, Astrocytic phosphoprotein PEA-15