anti-phosphodiesterase 9A (PDE9A) Antikörper

Human phosphodiesterase 9A (PDE9A) Interaktionspartner

1. PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target.

2. it is concluded that assessment of PDE5 and PDE9 expression may be useful in the differential diagnosis of benign and malignant breast disease and successful treatment of breast cancer

3. In vivo effects of PDE9A inhibition included reversal of the respective disruptions of working memory.

4. PDE9 is widely distributed in the urothelial epithelium of the human lower urinary tract and its potential roles may be different from those of PDE5.

5. Data show that PDE9A inhibitor, BAY-73-6691, significantly reduced basal and sickle cell (SCA) neutrophil adhesion; this was accompanied by decreased SCA neutrophil surface expressions of the L-selectin and CD11b adhesion molecules.

6. Identification and distribution of different variants produced by differential splicing of phosphodiesterase 9A mRNA.

7. X ray crystallography with IBMX inhibitor binding

8. The data suggests the utilization of two different start codons to produce a variety of different PDE9A proteins, allowing specific subcellular location of PDE9A splice variants.

9. PDE9A, is unlikely to play an important role in antidepressant outcome in this sample

Mouse (Murine) phosphodiesterase 9A (PDE9A) Interaktionspartner

1. Brain PDE9 is localized to preferentially regulate nuclear- and membrane-proximal pools of cGMP, and its function likely changes across the life span.

2. PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target.

3. Data suggest that increases in hippocampal and amygdalar cGMP levels via blockade of PDE9 have prominent roles in consolidation of extinction learning (here, prevention of learning disorder due to cocaine neurotoxicity).

4. This paper describes the human Pde9 gene but discusses the comparisons between the mouse and human Pde9 genes.

Cow (Bovine) phosphodiesterase 9A (PDE9A) Interaktionspartner

1. regulates bovine tracheal smooth muscle relaxation