gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 Proteine (GABRA1)

GABRA1 encodes a gamma-aminobutyric acid (GABA) receptor. Zusätzlich bieten wir Ihnen gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 Antikörper (180) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GABRA1 2554 P14867
Ratte GABRA1 GABRA1 29705 P62813
GABRA1 14394 P62812
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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GABRA1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine) ,
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Am meisten referenzierte gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 Proteine

  1. Human GABRA1 Protein expressed in Wheat germ - ABIN1354645 : Di, Wang, Han, Fu, Duerfeldt, Blagg, Mu: Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation. in The Journal of biological chemistry 2016 (PubMed)

Weitere Proteine zu gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) Interaktionspartnern

Human gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) Interaktionspartner

  1. The results further substantiate the role of GABRA1 in phenytoin mode of action in epilepsy.

  2. Our study findings showed COMT (zeige COMT Proteine) polymorphism conferring risk and GABRA1 and GABRA2 (zeige GABRA2 Proteine) polymorphism as a protective genotype for Indian male with alcohol dependence (AD)

  3. The polymorphism of rs1129647 and rs2290733 of GABRA1 has a nominal relationship with amphetamine-induced psychotic disorder .

  4. Study confirms GABRA1 mutations as significant contributors to the genetic etiology of both mild and severe epilepsy syndromes. GABRA1 mutations, through a possible mechanism of haploinsufficiency, cause an impairment of the GABA inhibitory function leading to a wide spectrum of epilepsy phenotypes.

  5. This unique case not only allows to further define the phenotypic spectrum of infantile epileptic encephalopathy associated with rare de novo GABRA1 variants but exemplifies the need for a sensitive review of unclear associations in clinically defined syndromes and for extended diagnostic work-up in individuals with unusual presentations of a genetically confirmed diagnosis.

  6. This study clarifies a Grp94 (zeige HSP90B1 Proteine)-mediated ERAD pathway for GABAA (zeige GABRg1 Proteine) receptors, which provides a novel way to finely tune their function in physiological and pathophysiological conditions.

  7. GABRA1 missense mutations were linked to early onset epileptic encephalopathies, including Ohtahara syndrome and West syndrome.

  8. Polymorphism rs4263535 in GABRA1 intron 4 was associated with deeper sedation by intravenous midazolam.

  9. Putative GABAA (zeige GABRg1 Proteine) and ASIC1a (zeige ACCN2 Proteine) channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.

  10. The role of the N-terminal extension and putative alpha-helix in heteromeric alpha1beta2gamma2 GABAA (zeige GABRg1 Proteine) receptors was most prominent in the alpha1 subunit. Deletion reduced the number of functional receptors.

Cow (Bovine) gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) Interaktionspartner

  1. GAPDH (zeige GAPDH Proteine) directly phosphorylates the long intracellular loop of GABA(A) receptor alpha1 subunit at identified serine and threonine residues. GAPDH (zeige GAPDH Proteine) and the alpha1 subunit were found to be colocalized at the neuronal plasma membrane.

  2. Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA (zeige GABRg1 Proteine)) receptors

Mouse (Murine) gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) Interaktionspartner

  1. This study suggests that movement of loop G in the beta1 strand of the GABAA (zeige GABRg1 Proteine) receptor alpha1 subunit is involved in a conformational rearrangement associated with channel activation

  2. These data suggest that GABA, acting through both presynaptic GABAA (zeige GABRg1 Proteine) and GABAB receptors, modulate the amplitude and short-term plasticity of excitatory synapses, a result not possible from activation of either receptor type alone

  3. Nbea targets glutamate (zeige GRIN1 Proteine) and GABA receptors to the synapse via distinct molecular pathways by interacting with specific effector proteins.

  4. the identity and location of distinct GABAAR (zeige GABRG2 Proteine) subunits within the cellular networks of the mouse dorsal raphe nucleus and that stress impacts on the expression levels of particular subunits at the gene and protein level

  5. This study demonstrated that Adolescent-onset GABAA (zeige GABRg1 Proteine) alpha1 silencing regulates reward-related decision making in mice.

  6. Enduring loss of tonic but not phasic GABAAR (zeige GABRG2 Proteine) currents critically contributes to the prolonged amygdala disinhibition subsequent to chronic stress.

  7. these findings suggest that gephyrin (zeige GPHN Proteine) may be a key factor in BDNF (zeige BDNF Proteine)-dependent GABAAR (zeige GABRG2 Proteine) regulation in the amygdala.

  8. Gabra1 receptors are expressed in the ventral thalamus in an absence epilepsy model.

  9. The effects of heterozygous knock-out of GABAAR (zeige GABRG2 Proteine) alpha1 on the expression and physiology of GABAARs in the mouse cortex, were determined.

  10. Cell-type specifici deletion of Gaba(a)alpha1 in corticotropin-releasing factor (zeige CRH Proteine)-containing neurons enhances anxiety and disrupts fear extinction.

gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) Protein Überblick

Protein Überblick

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene.

Genbezeichner und Symbole assoziert mit GABRA1

  • gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1)
  • gamma-aminobutyric acid (GABA) A receptor, alpha 1 (Gabra1)
  • gamma-aminobutyric acid (GABA) A receptor, alpha 1 (gabra1)
  • gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 (Gabra1)
  • gamma-aminobutyric acid A receptor subunit alpha-1 (gabra1)
  • ECA4 Protein
  • EJM Protein
  • EJM5 Protein
  • Gabra-1 Protein
  • zgc:153566 Protein

Bezeichner auf Proteinebene für GABRA1

GABA(A) receptor subunit alpha-1 , GABA(A) receptor, alpha 1 , gamma-aminobutyric acid receptor subunit alpha-1 , gamma-aminobutyric acid A receptor, alpha 1 , gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1 , gamma-aminobutyric acid A receptor, alpha 1 , gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 , GABAA alpha 1

GENE ID SPEZIES
2554 Homo sapiens
29705 Rattus norvegicus
489143 Canis lupus familiaris
780973 Bos taurus
374214 Gallus gallus
768183 Danio rerio
100172731 Pongo abelii
14394 Mus musculus
100653509 Xenopus laevis
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