anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) Antikörper

GABRA1 encodes a gamma-aminobutyric acid (GABA) receptor. Zusätzlich bieten wir Ihnen gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 Proteine (5) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GABRA1 2554 P14867
GABRA1 29705 P62813
GABRA1 14394 P62812
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Top anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 Antikörper auf antikoerper-online.de

Showing 10 out of 327 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-GABRA1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  721_B cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-GABRA1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-GABA A Receptor alpha 1 antibody, IHC(P) IHC(P): Rat Brain Tissue Anti-GABA A Receptor alpha 1 antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: Rat Brain Tissue Lysate 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert WB Western blot of rat forebrain lysates from Wild Type (Control) and ?1-knockout (?1-K/O) animals showing specific immunolabeling of the ~51k ?1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from ?1-knockout animals. Western Blot: GABA-A R alpha 1 Antibody [ABIN152533] - Analysis of forebraine lysates from wildtype (Lane A) and a1-knockout rats using 5-7 ug of tissue per lane. The antibody labeled the 51 kDa a1-subunit of GABAa-R. The labeling was absent from the lysate prepared from the a1-knockout animals. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$488.73
Details
Säugetier Maus Unkonjugiert ISt, IHC, WB   5 mL Anmelden zum Anzeigen 2 bis 6 Tage
$366.67
Details
Huhn Kaninchen Unkonjugiert WB Western blot analysis of GABRA1 expression in U87MG (A), NIH3T3 (B) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Rat Brain, antibody was diluted at 1:100. 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Ratte Kaninchen Unkonjugiert WB Western blots of mouse forebrain lysates from wild type (Control) and a1-knockout ((1-K/O) animals showing specific immunolabeling of the ~51k a1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from a1-knockout animals. Western blot of mouse forebrain lysates from wild type (WT) and α1-knockout (K/O) animals showing specific immunolabeling of the ~51 kDa α1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from α1-knockout animals. 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$508.20
Details
Human Kaninchen Unkonjugiert WB WB Image GABA A Receptor alpha 1 antibody detects GABA A Receptor alpha 1 protein by western blot analysis. Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with GABA A Receptor alpha 1 antibody , diluted by 1:1000. 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$466.18
Details
Human Maus Unkonjugiert ICC, IHC, IHC (p), IP, WB Anti-GABRB1 antibody IHC staining of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1101649 concentration 10 ug/ml. Anti-GABRB1 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details

Am meisten referenzierte anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 Antikörper

  1. Mammalian Monoclonal GABRA1 Primary Antibody für ISt, IHC - ABIN1304642 : Zhou, Ding, Deel, Ferrick, Emeson, Gallagher: Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome. in Neurobiology of disease 2014 (PubMed)
    Show all 27 Pubmed References

  2. Human Polyclonal GABRA1 Primary Antibody für WB - ABIN152533 : Herden, Pardo, Hajela, Yuan, Atchison: Differential effects of methylmercury on gamma-aminobutyric acid type A receptor currents in rat cerebellar granule and cerebral cortical neurons in culture. in The Journal of pharmacology and experimental therapeutics 2008 (PubMed)
    Show all 11 Pubmed References

  3. Cow (Bovine) Polyclonal GABRA1 Primary Antibody für WB - ABIN550204 : McKernan, Rosahl, Reynolds, Sur, Wafford, Atack, Farrar, Myers, Cook, Ferris, Garrett, Bristow, Marshall, Macaulay, Brown, Howell, Moore, Carling, Street, Castro, Ragan, Dawson, Whiting: Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. in Nature neuroscience 2000 (PubMed)
    Show all 3 Pubmed References

  4. Cow (Bovine) Polyclonal GABRA1 Primary Antibody für WB - ABIN550148 : Pöltl, Hauer, Fuchs, Tretter, Sieghart: Subunit composition and quantitative importance of GABA(A) receptor subtypes in the cerebellum of mouse and rat. in Journal of neurochemistry 2004 (PubMed)
    Show all 3 Pubmed References

  5. Rat (Rattus) Monoclonal GABRA1 Primary Antibody für ICC, IHC - ABIN1742455 : Acuna, Liu, Südhof: How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs. in Neuron 2016 (PubMed)

  6. Human Polyclonal GABRA1 Primary Antibody für IHC (p), WB - ABIN3044445 : Bao, Wang, Wei, Wang, Wuyun, Bo: Role of microRNA-4458 in patients with non-small-cell lung cancer. in Oncology letters 2016 (PubMed)

  7. Mouse (Murine) Polyclonal GABRA1 Primary Antibody für WB - ABIN152548 : Roberts, Hu, Lund, Brooks-Kayal, Russek: Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons. in The Journal of biological chemistry 2006 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 Interaktionspartner

Human gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) Interaktionspartner

  1. high-resolution cryo-electron microscopy structures of the human alpha1beta2gamma2 GABAA receptor, the predominant isoform in the adult brain, in complex with GABA and the benzodiazepine site antagonist flumazenil, the first-line clinical treatment for benzodiazepine overdose

  2. GBARA1 SNPs are associated with Lennox-Gastaut syndrome and juvenile myoclonic epilepsy in Indian patients.

  3. Gabra1 mutations significantly reduced surface expression of GABAARs in neurons and the alpha1A295D and alpha1T10'I mutations reduces expression in HEK293 cells. In addition, the alpha1D192N and alpha1T10'I mutations significantly accelerated the decay rate of GABAergic IPSCs. The alpha1T10'I mutation also reduced the number of GABAergic synaptic contacts in neurons.

  4. This study showed that GABRA1 expression in lateral nucleus of amygdala and dentate gyrus, ca1 region and subiculum of hippocampus.

  5. This study shown that the two SNPs located in the GABRA1 gene, rs4263535 (Pallele=0.002; uncorrected) and rs1157122 (Pallele=0.006; uncorrected) showed associated with Japanese individuals affected with schizophrenia.

  6. Rs2279020 (GABRA1, G > A) variation was associated with a decreased risk of developing VPA-resistant epilepsy.

  7. The results further substantiate the role of GABRA1 in phenytoin mode of action in epilepsy.

  8. Our study findings showed COMT polymorphism conferring risk and GABRA1 and GABRA2 polymorphism as a protective genotype for Indian male with alcohol dependence (AD)

  9. The polymorphism of rs1129647 and rs2290733 of GABRA1 has a nominal relationship with amphetamine-induced psychotic disorder .

  10. Study confirms GABRA1 mutations as significant contributors to the genetic etiology of both mild and severe epilepsy syndromes. GABRA1 mutations, through a possible mechanism of haploinsufficiency, cause an impairment of the GABA inhibitory function leading to a wide spectrum of epilepsy phenotypes.

  11. This unique case not only allows to further define the phenotypic spectrum of infantile epileptic encephalopathy associated with rare de novo GABRA1 variants but exemplifies the need for a sensitive review of unclear associations in clinically defined syndromes and for extended diagnostic work-up in individuals with unusual presentations of a genetically confirmed diagnosis.

  12. The alpha1 was expressed prenatally in the molecular and Purkinje cell layer, but only postnatally in the granule cell layer and the dentate nucleus.

  13. This study clarifies a Grp94-mediated ERAD pathway for GABAA receptors, which provides a novel way to finely tune their function in physiological and pathophysiological conditions.

  14. GABRA1 missense mutations were linked to early onset epileptic encephalopathies, including Ohtahara syndrome and West syndrome.

  15. Polymorphism rs4263535 in GABRA1 intron 4 was associated with deeper sedation by intravenous midazolam.

  16. Both GABAAalpha1 and GABAArho1 mRNAs and proteins were identified in cultured retinal pigment epithelial cells; antibody staining was mainly localized to the cell membrane and was also present in the cytoplasm but not in the nucleus.

  17. Putative GABAA and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.

  18. The role of the N-terminal extension and putative alpha-helix in heteromeric alpha1beta2gamma2 GABAA receptors was most prominent in the alpha1 subunit. Deletion reduced the number of functional receptors.

  19. These results suggest that ARG1 and GABA influence both neural development and neuroblastoma and that benzodiazepines in clinical use may have potential applications for neuroblastoma therapy.

  20. Tobacco smoking, but not nicotine interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal.

Cow (Bovine) gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) Interaktionspartner

  1. GAPDH directly phosphorylates the long intracellular loop of GABA(A) receptor alpha1 subunit at identified serine and threonine residues. GAPDH and the alpha1 subunit were found to be colocalized at the neuronal plasma membrane.

  2. Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors

Mouse (Murine) gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) Interaktionspartner

  1. This experiments show that loop F of the alpha-subunit governs the potency of GABA on alpha2 and alpha5-GABAA receptors in vitro as well as in vivo.

  2. This results of this study concluded that targeted deletion of Gabra1 causes moderate adaptations of GABAergic synapses in CA1 pyramidal cells

  3. We used a low-affinity antagonist to show that GABAA-receptor saturation occurs at this synapse but does not underlie frequency-invariant transmission.

  4. Results suggest that alpha1, alpha5 and gamma2-containing hippocampal GABA type A receptors complexes play an essential role in spatial learning and memory in which targeted disruption of the alpha1 subunit produces profound deficits.

  5. This study suggests that movement of loop G in the beta1 strand of the GABAA receptor alpha1 subunit is involved in a conformational rearrangement associated with channel activation

  6. These data suggest that GABA, acting through both presynaptic GABAA and GABAB receptors, modulate the amplitude and short-term plasticity of excitatory synapses, a result not possible from activation of either receptor type alone

  7. Nbea targets glutamate and GABA receptors to the synapse via distinct molecular pathways by interacting with specific effector proteins.

  8. Heterozygous loss of alpha1 subunit disinhibits the ventrobasal nucleus by substantially reducing phasic GABAergic currents and increases the reticular nucleus inhibition by prolonging phasic currents.

  9. the identity and location of distinct GABAAR subunits within the cellular networks of the mouse dorsal raphe nucleus and that stress impacts on the expression levels of particular subunits at the gene and protein level

  10. This study demonstrated that Adolescent-onset GABAA alpha1 silencing regulates reward-related decision making in mice.

  11. alpha1 Receptor subunits are co-expressed with beta2 and delta subunits along the extrasynaptic membranes in the dentate gyrus.

  12. Enduring loss of tonic but not phasic GABAAR currents critically contributes to the prolonged amygdala disinhibition subsequent to chronic stress.

  13. these findings suggest that gephyrin may be a key factor in BDNF-dependent GABAAR regulation in the amygdala.

  14. Gabra1 receptors are expressed in the ventral thalamus in an absence epilepsy model.

  15. The effects of heterozygous knock-out of GABAAR alpha1 on the expression and physiology of GABAARs in the mouse cortex, were determined.

  16. GABA(A) receptor alpha subunits differentially contribute to diazepam tolerance after chronic treatment.

  17. Cell-type specifici deletion of Gaba(a)alpha1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinction.

  18. haploinsufficiency can produce epilepsy

  19. Further support for an interaction between GABA(A) and metabotropic glutamate receptor subtype(mGlu)4 receptors is obtained in the mGlu4 knockout mouse which displayed reduced binding of the GABA(A)receptor in cerebellar parallel fibers.

  20. Our results also have potential implications for the therapeutic practices that involve exposure to GABA-A Receptor modulators during neurodevelopment.

gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1) Antigen-Profil

Protein Überblick

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene.

Genbezeichner und Symbole assoziert mit GABRA1

  • gamma-aminobutyric acid type A receptor alpha1 subunit (GABRA1) Antikörper
  • gamma-aminobutyric acid type A receptor alpha1 subunit (Gabra1) Antikörper
  • gamma-aminobutyric acid (GABA) A receptor, alpha 1 (gabra1) Antikörper
  • gamma-aminobutyric acid (GABA) A receptor, alpha 1 (GABRA1) Antikörper
  • gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 (Gabra1) Antikörper
  • gamma-aminobutyric acid receptor subunit alpha-1 (LOC100653509) Antikörper
  • ECA4 Antikörper
  • EJM Antikörper
  • EJM5 Antikörper
  • Gabra-1 Antikörper
  • zgc:153566 Antikörper

Bezeichner auf Proteinebene für GABRA1

GABA(A) receptor subunit alpha-1 , GABA(A) receptor, alpha 1 , gamma-aminobutyric acid receptor subunit alpha-1 , gamma-aminobutyric acid A receptor, alpha 1 , gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1 , gamma-aminobutyric acid A receptor, alpha 1 , gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 , GABAA alpha 1

GENE ID SPEZIES
2554 Homo sapiens
29705 Rattus norvegicus
489143 Canis lupus familiaris
780973 Bos taurus
374214 Gallus gallus
768183 Danio rerio
100172731 Pongo abelii
14394 Mus musculus
100653509 Xenopus laevis
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