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The enzyme encoded by GGT1 catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors.
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Human Monoclonal GGT1 Primary Antibody für IHC (p), IP - ABIN561038
West, Segu, Feasley, Kang, Klouckova, Li, Novotny, West, Mechref, Hanigan: Analysis of site-specific glycosylation of renal and hepatic ?-glutamyl transpeptidase from normal human tissue. in The Journal of biological chemistry 2010
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Human Polyclonal GGT1 Primary Antibody für WB - ABIN1881373
Ikeda, Maki, Yin, Kawate, Adachi, Ohnaka, Takayanagi, Kono: Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index. in Scandinavian journal of clinical and laboratory investigation 2010
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Mouse (Murine) Polyclonal GGT1 Primary Antibody für WB - ABIN1881372
Aly, Lightfoot, El-Shemy: Modulatory role of lipoic acid on lipopolysaccharide-induced oxidative stress in adult rat Sertoli cells in vitro. in Chemico-biological interactions 2009
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Human Polyclonal GGT1 Primary Antibody für IF, WB - ABIN516020
Scalise, Balia, Cianchetti, Neri, Carnicelli, Zucchi, Franzini, Corti, Paolicchi, Celi, Pedrinelli: Non enzymatic upregulation of tissue factor expression by gamma-glutamyl transferase in human peripheral blood mononuclear cells. in Thrombosis journal 2016
Data suggest that increased serum GGT level is independently associated with prevalence of hyperuricemia in middle-aged and elderly Chinese females.
elevated preoperative serum gamma-GGT was significantly associated with advanced tumor stage and aggressive tumor behaviors, and serum gamma-GGT can be considered as a prognostic factor for hepatocellular carcinoma patients after liver transplantation
Higher pre-treatment GGT serum levels were independently associated with unfavorable prognosis in women withu terine leiomyosarcoma (ULMS). Thus, GGT seems to be a useful novel biomarker in ULMS.
In a large Korean population-based study, elevated GGT levels were significantly associated with increased risk of atrial fibrillation.
The probe exhibits very high selectivity and sensitivity toward GGT activity from in vitro to in vivo and in clinical samples, which offers a promising tool for investigations of the GGT-overexpressing related biological process including tumor diagnosis and prognosis in living organisms.
both tumor GGT and serum GGT are poor prognostic factors in gastric cancer
The GPR (zeige ALDH18A1 Antikörper) could be used as a non-invasive marker to predict liver fibrosis and cirrhosis in CHB-NAFLD (zeige TSC2 Antikörper) individuals.
This study demonstrated a positive association between serum GGT levels and LV diastolic dysfunction and LV hypertrophy in a large cohort of middle-aged men and women independent of potential confounders.
we found that serum exosomal GGT activity was significantly higher in prostate cancer (PC), patients than in benign prostatic hyperplasia (BPH) patients. In support of this finding, immunohistochemical analysis showed increased GGT1 expression in PC tissues compared with BPH tissues. Our results suggest that serum exosomal GGT activity could be a useful biomarker for PC
GGT activity may serve as a potential surrogate biomarker of atherogenic risk and metabolic health status
These findings elucidate a novel mechanism of inflammation-associated osteoclastogenesis, which involves TLR4 (zeige TLR4 Antikörper) recognition of gamma-glutamyltranspeptidase and subsequent activation of MyD88 (zeige MYD88 Antikörper)-dependent signaling.
the present study developed a liver-specific GGT-overexpressing mice model and found that GGT elevation in short term had no effects on glucose metabolism but could increase insulin (zeige INS Antikörper) sensitivity through enhancing the activity of insulin (zeige INS Antikörper) signaling pathway.
Statins can significantly decrease the expression of GGT in aortic atherosclerotic plaques of ApoE (zeige APOE Antikörper)-knockout mice.
Gamma-glutamyltransferase levels are an independent predictor of worsening kidney function and mortality in acute heart failure patients.
Disruption of the Mrds1/Ofcc1 gene elicits asymptomatic hyper-gamma-glutamyl-transpeptidasemia in mice.
Mutations in the Ggt1 gene are responsible for the phenotypes of dwg/dwg and dwg(Bayer)/dwg(Bayer) mice.
prooxidant reactions mediated by gamma-GT in turn regulate the levels of tyrosinase (zeige TYR Antikörper) in pigment cells.
GGT regulates osteoclast biology at least partly independently of sex steroids
GGT stimulates RANKL (zeige TNFSF11 Antikörper) expression
GGT is implicated as being involved in diseases characterized by accelerated osteoclast development and bone destruction.
The enzyme encoded by this gene catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized and some of which may represent pseudogenes. This gene is classified as type I gamma-glutamyltransferase. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, gamma-glutamyltranspeptidase 1
, GGT 1
, gamma-glutamyl transpeptidase
, glutathione hydrolase 1
, leukotriene-C4 hydrolase
, glutamyl transpeptidase
, gamma glutamyl-transferase 1
, gamma-glutamyltransferase 2
, ggt 1
, gamma-glutamyltransferase 1 a
, Gamma-glutamyltranspeptidase 1
, gamma-glutamyltranspeptidase 1-like
, Gamma-glutamyltransferase 1