beta-Site APP-Cleaving Enzyme 1 Proteine (BACE)

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Zusätzlich bieten wir Ihnen beta-Site APP-Cleaving Enzyme 1 Antikörper (229) und beta-Site APP-Cleaving Enzyme 1 Kits (69) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
BACE 23621 P56817
BACE 23821 P56818
BACE 29392 P56819
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Top beta-Site APP-Cleaving Enzyme 1 Proteine auf antikoerper-online.de

Showing 10 out of 32 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Human Fc Tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$382.80
Details
Human Cells Maus His tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$382.80
Details
HEK-293 Cells Human Unkonjugiert 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$715.00
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,493.38
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
Details
Escherichia coli (E. coli) Maus His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$701.00
Details
Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$720.00
Details
Insektenzellen Human Unkonjugiert 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$595.00
Details
HEK-293 Cells Human His tag Human BACE-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$253.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details

BACE Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
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Mouse (Murine) , , ,
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Rat (Rattus) ,

Weitere Proteine zu beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartnern

Human beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. BACE1 regulates the expression of insulin receptor in the liver

  2. Results indicated that the proinflammatory cytokine TNF-alpha impairs endothelial tight junctions and promotes monocyte-endothelial cell adhesion by upregulating beta-site amyloid precursor protein enzyme 1 expression through activating PKC signaling and sequentially cleaving alpha-2, 6-sialic acid transferase 1.

  3. Study did not detect any difference in peripheral expression of BACE1 and its naturally occurring antisense in epileptic patients and healthy subjects but a significant correlation between the transcript levels of these genes.

  4. BACE1 is predominantly SUMOylated at K501 residue, which escalates its protease activity and stability and subsequently increases Abeta production.

  5. Their anti-BACE1 and antimicrobial activity.

  6. Structural arrangement of BACE1-TM trimers and a mechanism for copper ion conduction that might also apply to other proteins involved in metal ion transport.

  7. Potentials for beneficial or consequential effects resulting from pharmacologic inhibition of BACE1 are reviewed in context of ongoing clinical trials testing the effect of BACE1 candidate inhibitor drugs in Alzheimer's disease populations.

  8. Measured plasma levels of beta-secretase 1 (BACE1) long non-coding RNA(LncRNA) in Alzheimer disease (AD) patients and healthy controls; found plasma BACE1 LncRNA to be a specific biomarker for AD.

  9. Amyloid beta oligomers modulate BACE1 through an XBP-1-dependent pathway involving HRD1.

  10. Polymethoxyflavones isolated from citrus peels might be considered as promising BACE1 inhibitory agents that could lower Abeta production in Alzheimer disease.

  11. In BACE1 transgenic (Tg) mice, axonal regeneration was reduced when compared with wilde-type (WT) littermates at 3 and 10 days post crush. Study observed a decreased percentage of innervated neuromuscular junctions at 15 days post crush; and a functional recovery delay in the transgenic mice as it took 8 weeks for the compound muscle action potential amplitudes of Tg mice to begin to reach similar values comparable to WT.

  12. Our study demonstrated there may exist an association between BACE1 rs535860 polymorphism and focal seizures in Chinese Han males.

  13. This study shown that the protein expression of BACE1 is downregulated by chronic treatment with donepezil. This effect may be interpreted as evidence of disease modification.

  14. Endosome-to-TGN trafficking of BACE1 is regulated by Par3 and aPKC. This is a mechanism in pathogenesis of Alzheimer disease.

  15. Results indicate that SNX4-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.

  16. We discuss how the underlying mechanisms can be conceived and develop scenarios how the regulation of ion conductances by BACE1 might shape electric activity in the intact and diseased brain and heart

  17. Study showed that serum deprivation enhances ADAM10/17-mediated cleavage and secretion of enzymatically active BACE1. This could be the result of alterations in the lipid composition of the membrane that lead in disruption of membrane compartmentalization in lipid rafts and non-lipid rafts. At present the significance of BACE1 shedding in the development of Alzheimer's disease is unclear.

  18. Data suggest that trimerization of BACE1 requires transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala463 and Cys466 buried within trimer interface of the sulfur-rich core of TMSs; BACE1 appears to play role in compartmentalization of intracellular copper by transferring cytosolic copper to intracellular compartments.

  19. SEPT8 modulates beta-amyloidogenic processing of APP through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  20. the depletion of BIN1 increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Protein Überblick

Protein Überblick

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit BACE

  • beta-secretase 1 (BACE1)
  • beta-site APP cleaving enzyme 1 (Bace1)
  • beta-secretase 1 (Bace1)
  • beta-site APP-cleaving enzyme 1 (bace1)
  • ASP2 Protein
  • Bace Protein
  • BACE1 Protein
  • C76936 Protein
  • HSPC104 Protein
  • MGC145931 Protein
  • zgc:77409 Protein

Bezeichner auf Proteinebene für BACE

APP beta-secretase , asp 2 , aspartyl protease 2 , beta-secretase 1 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , memapsin-2 , membrane-associated aspartic protease 2 , transmembrane aspartic proteinase Asp2 , ASP2 , beta-site amyloid precursor protein cleaving enzyme 1 , beta-site APP cleaving enzyme , beta secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-site APP-cleaving enzyme 1 , beta-secretase 1-like

GENE ID SPEZIES
23621 Homo sapiens
23821 Mus musculus
29392 Rattus norvegicus
419768 Gallus gallus
489390 Canis lupus familiaris
614333 Bos taurus
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100071137 Equus caballus
100343442 Oryctolagus cuniculus
100459804 Pongo abelii
451573 Pan troglodytes
100025518 Monodelphis domestica
403005 Danio rerio
100135485 Cavia porcellus
100602656 Nomascus leucogenys
100511707 Sus scrofa
101119667 Ovis aries
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