beta-Site APP-Cleaving Enzyme 1 Proteine (BACE)

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Zusätzlich bieten wir Ihnen beta-Site APP-Cleaving Enzyme 1 Antikörper (232) und beta-Site APP-Cleaving Enzyme 1 Kits (69) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
BACE 23621 P56817
BACE 23821 P56818
BACE 29392 P56819
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Top beta-Site APP-Cleaving Enzyme 1 Proteine auf antikoerper-online.de

Showing 10 out of 32 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Maus His tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$440.65
Details
Human Cells Human Fc Tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$440.65
Details
HEK-293 Cells Human Unkonjugiert 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$715.00
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,493.38
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
Details
Escherichia coli (E. coli) Maus His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$701.00
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Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$720.00
Details
Insektenzellen Human Unkonjugiert 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$595.00
Details
HEK-293 Cells Human Fc Tag Human BACE-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%. 200 μg Anmelden zum Anzeigen 2 bis 3 Tage
$253.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
Details

BACE Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
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Mouse (Murine) , , ,
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Rat (Rattus) ,

Weitere Proteine zu beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartnern

Human beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. Overexpression of RTN3 T39 M in cultured neurons led to impaired axonal transport of BACE1. The variants found in this study are likely genetic modifiers for RTN3-mediated formation of neuritic plaques in Alzheimer's disease (AD).

  2. Study employed a targeted quantitative metabolomic methodology to measure brain metabolite changes occurring in PLB4 (neuron-specific human BACE1 knock-in) transgenic model. Carnosine and 8 phosphatidylcholine species were significantly decreased in 'young' PLB4 mouse brain. In 'old' PLB4 mice a total of 21 metabolites were perturbed. Within the PLB4 genotype there were a range of age-dependent increases in metabolites.

  3. Study delineates a novel CHOP-NF-kappaB signaling pathway that mediates palmitate-induced up-regulation of BACE1 expression and Abeta genesis.

  4. ORP150 and CHIP demonstrate antagonism under normal and stress conditions wherein they inversely regulate each other thus affecting BACE1 level.

  5. a gender dimorphism was observed in BACE1 gene expression in the patients in a way that the male patients manifested a statistically significant higher levels of BACE1 expression

  6. The BACE1 DISLL motif is phosphorylated and regulates endosomal trafficking, in primary neurons. Therefore, post-translational phosphorylation of DISLL enhances the exit of BACE1 from early endosomes, a pathway mediated by GGA1 and retromer, which is important in regulating Abeta production.

  7. BACE1 regulates the expression of insulin receptor in the liver

  8. Results indicated that the proinflammatory cytokine TNF-alpha impairs endothelial tight junctions and promotes monocyte-endothelial cell adhesion by upregulating beta-site amyloid precursor protein enzyme 1 expression through activating PKC signaling and sequentially cleaving alpha-2, 6-sialic acid transferase 1.

  9. Study did not detect any difference in peripheral expression of BACE1 and its naturally occurring antisense in epileptic patients and healthy subjects but a significant correlation between the transcript levels of these genes.

  10. BACE1 is predominantly SUMOylated at K501 residue, which escalates its protease activity and stability and subsequently increases Abeta production.

  11. Their anti-BACE1 and antimicrobial activity.

  12. Structural arrangement of BACE1-TM trimers and a mechanism for copper ion conduction that might also apply to other proteins involved in metal ion transport.

  13. Potentials for beneficial or consequential effects resulting from pharmacologic inhibition of BACE1 are reviewed in context of ongoing clinical trials testing the effect of BACE1 candidate inhibitor drugs in Alzheimer's disease populations.

  14. Measured plasma levels of beta-secretase 1 (BACE1) long non-coding RNA(LncRNA) in Alzheimer disease (AD) patients and healthy controls; found plasma BACE1 LncRNA to be a specific biomarker for AD.

  15. Amyloid beta oligomers modulate BACE1 through an XBP-1-dependent pathway involving HRD1.

  16. Polymethoxyflavones isolated from citrus peels might be considered as promising BACE1 inhibitory agents that could lower Abeta production in Alzheimer disease.

  17. In BACE1 transgenic (Tg) mice, axonal regeneration was reduced when compared with wilde-type (WT) littermates at 3 and 10 days post crush. Study observed a decreased percentage of innervated neuromuscular junctions at 15 days post crush; and a functional recovery delay in the transgenic mice as it took 8 weeks for the compound muscle action potential amplitudes of Tg mice to begin to reach similar values comparable to WT.

  18. Our study demonstrated there may exist an association between BACE1 rs535860 polymorphism and focal seizures in Chinese Han males.

  19. This study shown that the protein expression of BACE1 is downregulated by chronic treatment with donepezil. This effect may be interpreted as evidence of disease modification.

  20. Endosome-to-TGN trafficking of BACE1 is regulated by Par3 and aPKC. This is a mechanism in pathogenesis of Alzheimer disease.

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. that BACE1 functions as the enzyme initiating the first cleavage step and serves a scaffold for amyloid- beta precursor protein and Presenilin 1 endocytosis.

  2. Study delineates a novel CHOP-NF-kappaB signaling pathway that mediates palmitate-induced up-regulation of BACE1 expression and Abeta genesis.

  3. BACE1 regulates adult hippocampal neurogenesis in mice.

  4. Results suggest that the colocalization of beta-site amyloid precursor protein cleaving enzyme-1 and amyloid precursor protein is increased in the presence of both amyloid beta and p75 in cortical neurons.

  5. Results show that NPC1 loss-of-function in a mouse model of Niemann-Pick type C disease leads to enhanced cleavage of BACE1 substrates Sez6 and Sez6L, in addition to APP, and that this effect most likely involves altered trafficking of BACE1 and of its substrates within the endolysosomal system. Efficacy of Sez6 cleavage by BACE1 may be spatiotemporally differently regulated in contrast to the cleavage of Sez6L.

  6. network analysis supports an intimate connection between immune response via NF-kappaB and BACE1 signaling through the NRG1/Akt1 pathway.

  7. BACE1 regulates the expression of insulin receptor in the liver

  8. Beta-site APP cleaving enzyme 1 knockout (Bace1-/-) mice and rats differed in body weight, spontaneous locomotor activity, and prepulse inhibition of startle.

  9. These results provide evidence for an emerging role of BAG-1M in the regulation of BACE1 expression and AD pathogenesis and that targeting the BAG-1M-NF-kappaB complex may provide a mechanism for inhibiting Abeta production and plaque formation.

  10. we have demonstrated that raised hypothalamic Abeta1-42, in conjunction with HFD, is sufficient to induce leptin resistance in the absence of increased inflammation, ER stress, SOCS3 and PTP1B. Thus, counteracting raised Bace1 activity associated with chronic HFD will play a critical protective role against metabolic disease

  11. Amyloid beta oligomers modulate BACE1 through an XBP-1-dependent pathway involving HRD1.

  12. BACE1 deficiency develops abnormal clusters of immature neurons, forming doublecortin-positive neuroblasts, in the developing dentate gyrus, mainly in the subpial zone.

  13. Increased TNFR1 expression and signaling in injured peripheral nerves of mice with reduced BACE1 activity

  14. We aimed to explore the potential therapeutic effect of PGC-1alpha by generating a lentiviral vector to express human PGC-1alpha and target it by stereotaxic delivery to hippocampus and cortex of APP23 transgenic mice . Four months after hPGC-1alpha injection, mice showed improved spatial and recognition memory concomitant with a significant reduction in Abeta deposition, associated with a decrease in BACE1 expression

  15. that BACE1 deficiency enhances proliferation of Schwann cell due to the elevated Jag1/Delta1-Notch signaling

  16. the synaptic localization of APP, ADAM10, and BACE1 in the mouse cerebral cortex, was examined.

  17. study demonstrates that SEZ6 and SEZ6L are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF are suitable markers to monitor BACE1 inhibition in mice

  18. Chronic variable stress led to increased Bace1 expression in the hippocampus of young adult mice and the hippocampus, prefrontal cortex and amygdala of aged mice. The increased expression of Bace1 was associated with decreased methylation of several CpGs in the Bace1 promoter region.

  19. Results indicate that SNX4-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.

  20. In conclusion, glucocorticoid couples mGR with Galphas and triggers cAMP-PKA-CREB axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Protein Überblick

Protein Überblick

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit BACE

  • beta-secretase 1 (BACE1)
  • beta-site APP cleaving enzyme 1 (Bace1)
  • beta-secretase 1 (Bace1)
  • beta-site APP-cleaving enzyme 1 (bace1)
  • ASP2 Protein
  • Bace Protein
  • BACE1 Protein
  • C76936 Protein
  • HSPC104 Protein
  • MGC145931 Protein
  • zgc:77409 Protein

Bezeichner auf Proteinebene für BACE

APP beta-secretase , asp 2 , aspartyl protease 2 , beta-secretase 1 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , memapsin-2 , membrane-associated aspartic protease 2 , transmembrane aspartic proteinase Asp2 , ASP2 , beta-site amyloid precursor protein cleaving enzyme 1 , beta-site APP cleaving enzyme , beta secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-site APP-cleaving enzyme 1 , beta-secretase 1-like

GENE ID SPEZIES
23621 Homo sapiens
23821 Mus musculus
29392 Rattus norvegicus
419768 Gallus gallus
489390 Canis lupus familiaris
614333 Bos taurus
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100071137 Equus caballus
100343442 Oryctolagus cuniculus
100459804 Pongo abelii
451573 Pan troglodytes
100025518 Monodelphis domestica
403005 Danio rerio
100135485 Cavia porcellus
100602656 Nomascus leucogenys
100511707 Sus scrofa
101119667 Ovis aries
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