anti-beta-Site APP-Cleaving Enzyme 1 (BACE) Antikörper

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Human BACE BACE 23621 P56817
Anti-Maus BACE BACE 23821 P56818
Anti-Ratte BACE BACE 29392 P56819
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-beta-Site APP-Cleaving Enzyme 1 Antikörper auf antikoerper-online.de

Showing 10 out of 278 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IF, IHC, WB WB Suggested Anti-BACE1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Liver 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Bace1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Mouse Heart 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-BACE1 Antibody (N-term) (ABIN392201) in mouse heart tissue lysates (35 µg/lane). BACE1(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB The anti-Phospho-BACE-S498 Pab (ABIN389517) is used in Western blot to detect Phospho-BACE-S498 in mouse brain tissue lysate Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of anti-BACE Antibody (S498) (ABIN392200) in mouse cerebellum tissue lysates (35 µg/lane). BACE (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert IHC, WB Immunohistochemistry-Paraffin: BACE-1 Antibody (61-3E7) [NBP1-78995] - Adrenal gland tissue showing cytoplasmic staining of cortical cells (low and high magnification). Western Blot: BACE-1 Antibody (61-3E7) [NBP1-78995] - Analysis of BACE expression in SH-SY5Y whole cell lysate. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$345.00
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$275.00
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 followed by conjugation to the secondary antibody and DAB staining L1 rat brain lysates probed with Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 51kD. Observed band size:51kD. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$318.45
Details
Human Kaninchen Unkonjugiert IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using BACE (Ab-498) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HuvEc cells, using BACE (Ab-498) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details

Am meisten referenzierte anti-beta-Site APP-Cleaving Enzyme 1 Antikörper

  1. Human Polyclonal BACE Primary Antibody für IF (p), IHC (p) - ABIN725705 : Tian, Guo, Wu, Ma, Zhao: Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats. in Cellular and molecular neurobiology 2015 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal BACE Primary Antibody für CyTOF, FACS - ABIN4900525 : Cheng, He, Lee, Yao, Li, Shen: High activities of BACE1 in brains with mild cognitive impairment. in The American journal of pathology 2013 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal BACE Primary Antibody für IHC (p), WB - ABIN392201 : Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal BACE Primary Antibody für IHC, WB - ABIN4282833 : Prior, Dargusch, Ehren, Chiruta, Schubert: The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. in Alzheimer's research & therapy 2014 (PubMed)

  5. Human Polyclonal BACE Primary Antibody für WB - ABIN550289 : Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. in Science (New York, N.Y.) 1999 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen beta-Site APP-Cleaving Enzyme 1 Interaktionspartner

Human beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. Potentials for beneficial or consequential effects resulting from pharmacologic inhibition of BACE1 are reviewed in context of ongoing clinical trials testing the effect of BACE1 candidate inhibitor drugs in Alzheimer's disease populations.

  2. Measured plasma levels of beta-secretase 1 (BACE1) long non-coding RNA(LncRNA) in Alzheimer disease (AD) patients and healthy controls; found plasma BACE1 LncRNA to be a specific biomarker for AD.

  3. Amyloid beta oligomers modulate BACE1 through an XBP-1 (zeige XBP1 Antikörper)-dependent pathway involving HRD1 (zeige SYVN1 Antikörper).

  4. Polymethoxyflavones isolated from citrus peels might be considered as promising BACE1 inhibitory agents that could lower Abeta (zeige APP Antikörper) production in Alzheimer disease.

  5. In BACE1 transgenic (Tg) mice, axonal regeneration was reduced when compared with wilde-type (WT) littermates at 3 and 10 days post crush. Study observed a decreased percentage of innervated neuromuscular junctions at 15 days post crush; and a functional recovery delay in the transgenic mice as it took 8 weeks for the compound muscle action potential amplitudes of Tg mice to begin to reach similar values comparable to WT.

  6. Our study demonstrated there may exist an association between BACE1 rs535860 polymorphism and focal seizures in Chinese Han males.

  7. This study shown that the protein expression of BACE1 is downregulated by chronic treatment with donepezil. This effect may be interpreted as evidence of disease modification.

  8. Endosome-to-TGN (zeige TG Antikörper) trafficking of BACE1 is regulated by Par3 (zeige F2RL2 Antikörper) and aPKC. This is a mechanism in pathogenesis of Alzheimer disease.

  9. Results indicate that SNX4 (zeige SNX4 Antikörper)-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.

  10. We discuss how the underlying mechanisms can be conceived and develop scenarios how the regulation of ion conductances by BACE1 might shape electric activity in the intact and diseased brain and heart

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. Amyloid beta oligomers modulate BACE1 through an XBP-1 (zeige XBP1 Antikörper)-dependent pathway involving HRD1 (zeige SYVN1 Antikörper).

  2. BACE1 deficiency develops abnormal clusters of immature neurons, forming doublecortin (zeige DCX Antikörper)-positive neuroblasts, in the developing dentate gyrus, mainly in the subpial zone.

  3. Increased TNFR1 (zeige TNFRSF1A Antikörper) expression and signaling in injured peripheral nerves of mice with reduced BACE1 activity

  4. We aimed to explore the potential therapeutic effect of PGC-1alpha by generating a lentiviral vector to express human PGC-1alpha and target it by stereotaxic delivery to hippocampus and cortex of APP23 transgenic mice . Four months after hPGC-1alpha injection, mice showed improved spatial and recognition memory concomitant with a significant reduction in Abeta (zeige APP Antikörper) deposition, associated with a decrease in BACE1 expression

  5. that BACE1 deficiency enhances proliferation of Schwann cell due to the elevated Jag1 (zeige JAG1 Antikörper)/Delta1-Notch (zeige NOTCH1 Antikörper) signaling

  6. the synaptic localization of APP (zeige APP Antikörper), ADAM10 (zeige ADAM10 Antikörper), and BACE1 in the mouse cerebral cortex, was examined.

  7. study demonstrates that SEZ6 and SEZ6L (zeige SEZ6L Antikörper) are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF (zeige CSF2 Antikörper) are suitable markers to monitor BACE1 inhibition in mice

  8. Chronic variable stress led to increased Bace1 expression in the hippocampus of young adult mice and the hippocampus, prefrontal cortex and amygdala of aged mice. The increased expression of Bace1 was associated with decreased methylation of several CpGs in the Bace1 promoter region.

  9. Results indicate that SNX4 (zeige SNX4 Antikörper)-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.

  10. In conclusion, glucocorticoid couples mGR (zeige GRHL1 Antikörper) with Galphas (zeige GNAS Antikörper) and triggers cAMP-PKA-CREB (zeige CREB1 Antikörper) axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta (zeige APP Antikörper) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) Interaktionspartner

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (zeige BACE2 Antikörper) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) Antigen-Profil

Protein Überblick

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit BACE

  • beta-secretase 1 (BACE1) Antikörper
  • beta-site APP cleaving enzyme 1 (Bace1) Antikörper
  • beta-secretase 1 (Bace1) Antikörper
  • beta-site APP-cleaving enzyme 1 (bace1) Antikörper
  • ASP2 Antikörper
  • Bace Antikörper
  • BACE1 Antikörper
  • C76936 Antikörper
  • HSPC104 Antikörper
  • MGC145931 Antikörper
  • zgc:77409 Antikörper

Bezeichner auf Proteinebene für BACE

APP beta-secretase , asp 2 , aspartyl protease 2 , beta-secretase 1 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , memapsin-2 , membrane-associated aspartic protease 2 , transmembrane aspartic proteinase Asp2 , ASP2 , beta-site amyloid precursor protein cleaving enzyme 1 , beta-site APP cleaving enzyme , beta secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-site APP-cleaving enzyme 1 , beta-secretase 1-like

GENE ID SPEZIES
23621 Homo sapiens
23821 Mus musculus
29392 Rattus norvegicus
419768 Gallus gallus
489390 Canis lupus familiaris
614333 Bos taurus
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100071137 Equus caballus
100343442 Oryctolagus cuniculus
100459804 Pongo abelii
451573 Pan troglodytes
100025518 Monodelphis domestica
403005 Danio rerio
100135485 Cavia porcellus
100602656 Nomascus leucogenys
100511707 Sus scrofa
101119667 Ovis aries
Haben Sie etwas anderes gesucht?