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acts as a transcriptional repressor\; may play a role in osteoclastogenesis [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen ZBTB7A Antikörper (110) und ZBTB7A Kits (11) und viele weitere Produktgruppen zu diesem Protein an.
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Results indicate the reverse association between the expression of ZBTB7A and the tumorigenicity of nasopharyngeal carcinoma (NPC (zeige NPC1 Proteine)).
Alveolar macrophages deficient in Zbtb7a failed to induce antibody and T cell responses.
Variants of ZBTB7A (LRF) and its beta-globin (zeige HBB Proteine) gene cluster binding motifs in sickle cell anemia/
This analysis complements the understanding of the mutational landscape of core binding factor (zeige CBFB Proteine) acute myeloid leukemia (zeige BCL11A Proteine), and has led to the identification of novel ZBTB7A mutations in t(8;21) acute myeloid leukemia (zeige BCL11A Proteine) subgroup.
Lymphoma-related factor mediates the protease-activated receptor 2 (zeige F2RL1 Proteine)-suppressed p53 (zeige TP53 Proteine) expression in the cancer cells and binds DAP5 (zeige EIF4G2 Proteine) to interfere with the gene transcription of p53 (zeige TP53 Proteine) in colon cancer cells.
Our study uncovers the loss-of-function mutation in ZBTB7A as a novel mechanism causing elevated glycolysis in human cancer, which carries important therapeutic implication.
Mutation in ZBTB7A is associated with core-binding factor (zeige CBFB Proteine) acute myeloid leukemia (zeige BCL11A Proteine).
Zbtb7a knockdown by siRNA suppressed cell proliferation and i (zeige MLXIP Proteine)nduced G1 cell cycle arrest and apoptosis (zeige MLXIP Proteine) in lung cancer cells. Furthermore, miR-125a expression showed a negative correlation with Zbtb7a expression in non-small cell lung cancer tissues.
Data suggest that microRNA miR (zeige MLXIP Proteine)-520e directly targets to the 3'-untranslated region (3'-UTR) of zinc finger and BTB domain containing 7A protein (Zbtb7a).
CCAT2 promotes tumorigenesis by over-expression of Pokemon.
this study shows that Thpok (zeige ZBTB7B Proteine) and LRF are redundantly required to maintain the size and functions of the postthymic Treg pool
This study identified Zbtb7a as a novel direct target for miR (zeige MLXIP Proteine)-125a by gene expression profiling in miR (zeige MLXIP Proteine)-125a knockout mice combined with bioinformatics target prediction, and elucidated the role of Zbtb7a in oncogenesis.
This study demonstrated an unexpected transcription-independent function for LRF in the classical non-homologous end joining pathway of double-strand break repair.
LRF short hairpin RNA suppressed the expression of LRF protein in a glioma cell line compared to the negative control vector-transfected glioma cells. LRF knockdown also reduced cell viability and enhanced cisplatin-induced apoptosis in glioma cells.
Data indicate that transcription factors Thpok (zeige ZBTB7B Proteine) and LRF redundantly maintain CD4 (zeige CD4 Proteine)+ lineage integrity.
Findings demonstrate that Pokemon suppresses Sprouty1 expression through a miR (zeige MLXIP Proteine)-21-mediated mechanism, affecting the growth and proliferation of liver cancer cells.
Data show that Notch1 (zeige NOTCH1 Proteine)/Dll4 (zeige DLL4 Proteine)-mediated T-cell instructive signals to long-term HSCs (LT-HSCs) are suppressed by Lrf expression in the bone marrow microenvironment.
These results support a critical role for LRF in transcriptional control of differentiation in oligodendrocyte lineage cells during developmental myelination in the CNS.
T cells lacking Thpok (zeige ZBTB7B Proteine), which only displayed LRF-dependent functions, contributed to multiple effector responses, both in vitro and in vivo, with the notable exception of Th2 cell responses that control extracellular parasites
acts as a transcriptional repressor\; may play a role in osteoclastogenesis
zinc finger and BTB domain containing 7A
, similar to zinc finger and BTB domain containing 36
, HIV-1 1st-binding protein 1
, HIV-1 inducer of short transcripts binding protein
, POK erythroid myeloid ontogenic factor
, POZ and Krueppel erythroid myeloid ontogenic factor
, TTF-I-interacting peptide 21
, factor binding IST protein 1
, factor that binds to inducer of short transcripts protein 1
, leukemia/lymphoma-related factor
, lymphoma related factor
, zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein
, zinc finger and BTB domain-containing protein 7A
, zinc finger protein 857A
, leukemia/lymphoma related factor
, osteoclast-derived zinc finger protein
, leukemia/lymphoma related factor cLRF