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acts as a transcriptional repressor\; may play a role in osteoclastogenesis [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen ZBTB7A Kits (11) und ZBTB7A Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ZBTB7A Primary Antibody für IP, IHC - ABIN152180
Aggarwal, Hunter, Aggarwal, Silva, Davey, Murphy, Agrawal: Expression of leukemia/lymphoma-related factor (LRF/POKEMON) in human breast carcinoma and other cancers. in Experimental and molecular pathology 2010
Show all 3 Pubmed References
Human Polyclonal ZBTB7A Primary Antibody für IHC, IHC (p) - ABIN4366685
Lunardi, Ala, Epping, Salmena, Clohessy, Webster, Wang, Mazzucchelli, Bianconi, Stack, Lis, Patnaik, Cantley, Bubley, Cordon-Cardo, Gerald, Montironi, Signoretti, Loda, Nardella, Pandolfi: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. in Nature genetics 2013
Human Polyclonal ZBTB7A Primary Antibody für IHC (p), IP - ABIN152181
Sebestyén, Sticz, Márk, Hajdu, Timár, Nemes, Nagy, Váradi, Kopper: Activity and complexes of mTOR in diffuse large B-cell lymphomas--a tissue microarray study. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012
Human Polyclonal ZBTB7A Primary Antibody für IF (p), IHC (p) - ABIN729448
Zhao, Yao, Li, An, Chen, Sun, Kang, Wang, Hu: Pokemon enhances proliferation, cell cycle progression and anti-apoptosis activity of colorectal cancer independently of p14(ARF)-MDM2-p53 pathway. in Medical oncology (Northwood, London, England) 2014
This analysis complements the understanding of the mutational landscape of core binding factor (zeige CBFB Antikörper) acute myeloid leukemia (zeige BCL11A Antikörper), and has led to the identification of novel ZBTB7A mutations in t(8;21) acute myeloid leukemia (zeige BCL11A Antikörper) subgroup.
Lymphoma-related factor mediates the protease-activated receptor 2 (zeige F2RL1 Antikörper)-suppressed p53 (zeige TP53 Antikörper) expression in the cancer cells and binds DAP5 (zeige EIF4G2 Antikörper) to interfere with the gene transcription of p53 (zeige TP53 Antikörper) in colon cancer cells.
Our study uncovers the loss-of-function mutation in ZBTB7A as a novel mechanism causing elevated glycolysis in human cancer, which carries important therapeutic implication.
Mutation in ZBTB7A is associated with core-binding factor (zeige CBFB Antikörper) acute myeloid leukemia (zeige BCL11A Antikörper).
Zbtb7a knockdown by siRNA suppressed cell proliferation and i (zeige MLXIP Antikörper)nduced G1 cell cycle arrest and apoptosis (zeige MLXIP Antikörper) in lung cancer cells. Furthermore, miR-125a expression showed a negative correlation with Zbtb7a expression in non-small cell lung cancer tissues.
Data suggest that microRNA miR (zeige MLXIP Antikörper)-520e directly targets to the 3'-untranslated region (3'-UTR (zeige UTS2R Antikörper)) of zinc finger and BTB domain containing 7A protein (Zbtb7a).
CCAT2 promotes tumorigenesis by over-expression of Pokemon.
High FBI-1 expression is associated with hepatocellular carcinoma.
there is an auto-regulatory circuit consisting of miR (zeige MLXIP Antikörper)-125 and Pokemon, which promotes the progression of HCC (zeige FAM126A Antikörper) and may be a promising therapeutic target in clinical HCC (zeige FAM126A Antikörper) treatment
Pokemon was found to enhance the migration and invasion of hepatocellular carcinoma by increasing MEF2D (zeige MEF2D Antikörper) expression
this study shows that Thpok (zeige ZBTB7B Antikörper) and LRF are redundantly required to maintain the size and functions of the postthymic Treg pool
This study identified Zbtb7a as a novel direct target for miR (zeige MLXIP Antikörper)-125a by gene expression profiling in miR (zeige MLXIP Antikörper)-125a knockout mice combined with bioinformatics target prediction, and elucidated the role of Zbtb7a in oncogenesis.
This study demonstrated an unexpected transcription-independent function for LRF in the classical non-homologous end joining pathway of double-strand break repair.
LRF short hairpin RNA suppressed the expression of LRF protein in a glioma cell line compared to the negative control vector-transfected glioma cells. LRF knockdown also reduced cell viability and enhanced cisplatin-induced apoptosis in glioma cells.
Data indicate that transcription factors Thpok (zeige ZBTB7B Antikörper) and LRF redundantly maintain CD4 (zeige CD4 Antikörper)+ lineage integrity.
Findings demonstrate that Pokemon suppresses Sprouty1 expression through a miR (zeige MLXIP Antikörper)-21-mediated mechanism, affecting the growth and proliferation of liver cancer cells.
Data show that Notch1 (zeige NOTCH1 Antikörper)/Dll4 (zeige DLL4 Antikörper)-mediated T-cell instructive signals to long-term HSCs (LT-HSCs) are suppressed by Lrf expression in the bone marrow microenvironment.
These results support a critical role for LRF in transcriptional control of differentiation in oligodendrocyte lineage cells during developmental myelination in the CNS.
T cells lacking Thpok (zeige ZBTB7B Antikörper), which only displayed LRF-dependent functions, contributed to multiple effector responses, both in vitro and in vivo, with the notable exception of Th2 cell responses that control extracellular parasites
study shows that LRF plays stage-specific distinct roles in osteoclast differentiation, exemplifying the delicate transcriptional regulation at work in lineage commitment
acts as a transcriptional repressor\; may play a role in osteoclastogenesis
zinc finger and BTB domain containing 7A
, similar to zinc finger and BTB domain containing 36
, HIV-1 1st-binding protein 1
, HIV-1 inducer of short transcripts binding protein
, POK erythroid myeloid ontogenic factor
, POZ and Krueppel erythroid myeloid ontogenic factor
, TTF-I-interacting peptide 21
, factor binding IST protein 1
, factor that binds to inducer of short transcripts protein 1
, leukemia/lymphoma-related factor
, lymphoma related factor
, zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein
, zinc finger and BTB domain-containing protein 7A
, zinc finger protein 857A
, leukemia/lymphoma related factor
, osteoclast-derived zinc finger protein
, leukemia/lymphoma related factor cLRF