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Down-regulates the expression of several chemokine receptors.
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Transcriptional suppressor OTK18 plays a role in macrophage control of viral replication during advanced HIV-1 infection.
OTK18/zinc finger protein 175 expression in brain mononuclear phagocytes is a signature for advanced HIV-1 encephalitis.
Plasma OTK18 levels are positively correlated to CD8 (zeige CD8A Proteine) T-cell counts, independent of HIV-1 status.
These results suggest a role for OTK18 in innate immunity.
These data suggest that calpain and proteasome are involved in OTK18 endoproteolysis and degradation
HIV-1 induces OTK18 expression through a YIN-YANG-1 (zeige YY1 Proteine) mediated manner in human macrophages
OTK18 may play a role in neurotrophin (zeige BDNF Proteine) production and consequently support neuronal survival.
Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat- induced viral LTR promoter activity.
zinc finger protein 175
, zinc finger protein OTK18