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ZFP36L1 is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF.
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A ZFP36L1-mediated regulatory circuit through repressing CDK6 (zeige CDK6 ELISA Kits) expression.
Gene expression analysis revealed that three gene BACH2, PTGER4 and ZFP36L1, are down-regulated in MS patients' blood cells compared to healthy subjects.
ZFP36L1 interacts with and mediates degradation of anti-apoptotic BCL2 (zeige BCL2 ELISA Kits) mRNA as its important target in malignant B-cells.
regulator of renal mineralocorticoid receptor abundance
NR4A2 (zeige NR4A2 ELISA Kits) expression is negatively regulated by zinc finger protein 36, C3H1 (zeige ZFP36 ELISA Kits) type-like 1 (Zfp36l1).
The roles of TTP and BRF proteins in regulated mRNA decay.
ZFP36L1 negatively regulates erythroid differentiation by directly binding the 3' untranslated region of Stat5b (zeige STAT5B ELISA Kits) encoding mRNA.
these results suggest an important role of ZFP36L1 in wound healing.
polymorphisms sequenced in genomic DNA encoding the TTP protein (ZFP36) and those of its two known mammalian relatives, ZFP36L1 and ZFP36L2, from 72 to 92 anonymous human subjects from various geographical and ethnic backgrounds
Data suggest an important role for butyrate response factor-1 in osteoblasts within the molecular network of parathyroid hormone (zeige PTH ELISA Kits)-dependent bone remodeling.
the ZFP36L1-dependent regulation of bile acid metabolism is an important metabolic contributor to obesity and hepatosteatosis.
The Zfp36l1 therefore act as posttranscriptional safeguards against chromosomal instability and replication stress by integrating pre-TCR and IL-7 (zeige IL7 ELISA Kits) signaling with DNA damage and cell cycle control.
Our data indicated that ZFP36L1 could act as an enhancer of osteoblastic differentiation but a repressor of adipogenic differentiation, supporting the notion that decreased ZFP36L1 expression in bone marrow stem cells might contribute to aging-related bone loss.
ZFP36L1 is the regulator of a post-transcriptional hub that determined the identity of marginal-zone B cells by promoting their proper localization and survival. ZFP36L1 controlled a gene-expression program related to signaling, cell adhesion and locomotion; it achieved this in part by limiting expression of the transcription factors KLF2 (zeige KLF2 ELISA Kits) and IRF8 (zeige IRF8 ELISA Kits), which are known to enforce e follicular B cell phenotype.
ZFP36L1 and ZFP36L2 suppress an evolutionarily conserved posttranscriptional regulon consisting of messenger RNAs whose protein products cooperatively promote transition into the S phase of the cell cycle.
Myeloid ZFP36 (zeige ZFP36 ELISA Kits) may fully compensate for loss of ZFP36L1.
Challenging the renal osmotic gradient by submitting mice to water deprivation, diuretic administration, or high-Na(+) diet increased renal Tis11b and decreased mineralocorticoid receptor (zeige NR3C2 ELISA Kits) expression, particularly in the cortex.
Findings suggest that ZFP36L1 negatively regulates plasmacytoid differentiation, at least in part, by targeting the expression of BLIMP1 (zeige PRDM1 ELISA Kits).
Data revealed that ZFP36L1 and ZFP36L2 bound to the 3' untranslated region (UTR (zeige UTS2R ELISA Kits)) of MAPK phosphatase-1 (MKP-1 (zeige DUSP1 ELISA Kits)) mRNA and downregulated Mkp-1 (zeige DUSP1 ELISA Kits) 3'UTR (zeige UTS2R ELISA Kits)-mediated luciferase activity.
This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CCCH zinc finger protein C3H-2
, zinc finger protein 36, C3H type-like 1
, EGF-response factor 1
, butyrate response factor 1
, early response factor Berg36
, zinc finger protein 36, C3H1 type-like 1
, zinc finger protein, C3H type, 36-like 1
, EGF-inducible protein CMG1