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acidic cysteine-rich protein associated with the mammary gland\; a major constituent of milk\; may function as a protease inhibitor [RGD, Feb 2006]..
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WAP plays a negative regulatory role in the cell-cycle progression of mammary epithelial cells through an autocrine/paracrine mechanism.
Wap regulates the proliferation of mammary epithelial cells by preventing serine protease (zeige F2 Proteine) from degrading laminin.
tight regulation of WAP gene expression parallels variations in the chromatin structure and DNA methylation (zeige HELLS Proteine) profile throughout the Ramp3 (zeige RAMP3 Proteine)-WAP-Tbrg4 (zeige TBRG4 Proteine) locus.
milk protein (zeige CSN1S2A Proteine) genes are subject to nuclear repositioning when activated, in agreement with a role for nuclear architecture in gene regulation, but that they behave differently as a function of their chromosomal context
Data show demonstrated that the Wap-rtTA knockin allele allows a tightly controlled temporal and spatial expression of transgenes in the mammary gland in a ligand-inducible manneer.
acidic cysteine-rich protein associated with the mammary gland\; a major constituent of milk\; may function as a protease inhibitor
whey acidic protein
, whey phosphoprotein