anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) Antikörper

WNK1 encodes a member of the WNK subfamily of serine/threonine protein kinases. Zusätzlich bieten wir Ihnen WNK1 Kits (7) und WNK1 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
WNK1 65125 Q9H4A3
WNK1 232341 P83741
WNK1 116477 Q9JIH7
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Top anti-WNK1 Antikörper auf antikoerper-online.de

Showing 10 out of 175 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of WNK1 expression in rat testis extract ( Lane 1). WNK1 at 250KD was detected using rabbit anti- WNK1 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). WNK1 was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti-WNK1 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, IHC, WB ABIN6267692 staining 293 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. ABIN6267692 at 1/100 staining human Lung carcinoma tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert ICC, IF, WB Western Blot: WNK1 Antibody [ABIN153167] - Detection of the short form of WNK1 in F-11 cell lysate. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$418.10
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from 293 cells treated with EGF 200ng/ml 30', using WNK1 (Phospho-Thr58) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using WNK1 (Phospho-Thr58) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from 293 cells, treated with EGF 200ng/ml 30', using WNK1 (Ab-58) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using WNK1 (Ab-58) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Fledermaus Kaninchen Unkonjugiert IHC, IHC (p) Anti-WNK1 antibody  ABIN1049464 IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-WNK1 / p65 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Fledermaus Kaninchen Unkonjugiert ELISA, IHC, IHC (p) Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with WNK1 antibody ABIN213554 at 4 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-WNK1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Human Testis (formalin-fixed, paraffin-embedded) stained with WNK1 antibody ABIN213556 at 7 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-WNK1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details

Am meisten referenzierte anti-WNK1 Antikörper

  1. Human Polyclonal WNK1 Primary Antibody für ICC, IF - ABIN153167 : Wade, Fang, Liu, Li, Yang, Subramanya, Maouyo, Mason, Ellison, Welling: WNK1 kinase isoform switch regulates renal potassium excretion. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 3 Pubmed References

  2. Polyclonal WNK1 Primary Antibody für WB - ABIN540241 : Xu, Lee, Min, Lenertz, Heise, Stippec, Goldsmith, Cobb: WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension. in Cell research 2005 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen WNK1 Interaktionspartner

Human WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. SNP rs1468326 of WNK1, rs6749447 of STK39, and WNK1 haplotype AGACAGGAATCGT were associated with hypertension in Tibetan individuals

  2. A new WNK1/HSN2 founder mutation has been found in Japanese patients with hereditary sensory and autonomic neuropathy.

  3. Small interfering RNA knockdown of MAPK7 demonstrated that MAPK7 regulates a subset of WNK1-regulated genes and controls the migration and cell proliferation

  4. The AA genotype of WNK1 rs1468326 is related with an increased risk for preeclampsia.

  5. Mutated WNK1 is a driver of chronic lymphocytic leukemia.

  6. Using small-interfering RNA-mediated WNK1 knockdown, we show autophagosome formation and autophagic flux are accelerated. In cells with reduced WNK1, basal and starvation-induced autophagy is increased. We also show that depletion of WNK1 stimulates focal class III phosphatidylinositol 3-kinase complex (PI3KC3) activity, which is required to induce autophagy.

  7. WNK1 and the associated phosphorylation of the PCF11 CID act to promote transcript release from chromatin-associated Pol II, which in turn facilitates mRNA export to the cytoplasm

  8. Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1/Cdc42 pathway.

  9. NKCC1 and KCCs are coordinately regulated by L-WNK1 isoforms.

  10. Single nucleotide polymorphisms STK39 and WNK were associated with hypertension and BP in our multicenter Belgian case-control study

  11. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  12. Identify a new chimeric transcript generated by the fusion of WNK1 and B4GALNT3 genes, correlated with B4GALNT3 overexpression in papillary thyroid carcinoma.

  13. a novel gene, WNK1, for susceptibility to pelvic organ prolapse

  14. findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 substrate, thereby linking aldosterone and other NEDD4-2-suppressing antinatriuretic hormones to NCC phosphorylation status.

  15. enhances BK channel function by reducing ERK1/2 signaling-mediated lysosomal degradation of the channel

  16. conclude that although multiple candidate genes are involved in development of hypertension, the genetic polymorphism in WNK1 is not a major contributor to the observed variability in blood pressure and familial clustering risk of hypertension

  17. study identifies a separation of functions for the WNK1-activated protein kinases OSR1 and SPAK in mediating proliferation, invasion, and gene expression in endothelial cells

  18. Report generation of WNK1 knockout cell lines and effects on WNK signaling.

  19. data suggest that WNK1 functions as a chloride sensor through direct binding of a regulatory chloride ion to the active site, which inhibits autophosphorylation

  20. our data show a novel role for the WNK1/OSR1/NKCC1 pathway in glioma migration

Pig (Porcine) WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Chimpanzee WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Rhesus Monkey WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Horse (Equine) WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).

Mouse (Murine) WNK Lysine Deficient Protein Kinase 1 (WNK1) Interaktionspartner

  1. GABAAR-dependent regulation of KCC2 diffusion involves phosphorylation of its T906/T1007 residues by WNK1.

  2. reduced age-dependent weight gain of WNK1 TG mice seems to be related with the decreased Kir6.2 expression via WNK1- and WNK4-regulated protein stability of Kir6.2.

  3. The differential regulation of ROMK, large-conductance Ca(2+)-activated K(+) (BK) channel, BK-alpha and NKCC2 between female and male mice, at least, were partly mediated via WNK1 pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.

  4. this study identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration

  5. Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1/Cdc42 pathway.

  6. Electrophysiological analysis showed that WNK1/HSN2 shifted the concentration of Cl(-)such that GABA signaling resulted in a less hyperpolarized state (increased neuronal activity) rather than a more hyperpolarized state (decreased neuronal activity) in mouse spinal nerves.

  7. A high-K(+) diet induced an increase in L-WNK1 expression selectively in intercalated cells and may contribute to enhanced BK channel expression and K(+) secretion in collecting ducts.

  8. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  9. findings indicate that the proline-rich exons are modular cassettes that convert WNK1 into a NEDD4-2 substrate, thereby linking aldosterone and other NEDD4-2-suppressing antinatriuretic hormones to NCC phosphorylation status.

  10. enhances BK channel function by reducing ERK1/2 signaling-mediated lysosomal degradation of the channel

  11. increased protein expression levels of WNK1 and WNK4 kinases cause PHAII by KLHL3 R528H mutation due to impaired KLHL3-Cullin3-mediated ubiquitination.

  12. study identifies a separation of functions for the WNK1-activated protein kinases OSR1 and SPAK in mediating proliferation, invasion, and gene expression in endothelial cells

  13. WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.

  14. Results show that the expression profiles of Wnk1 isoforms change during the development, and that the expression of the Wnk1 splice variant containing the Hsn2 exon is prominent during developing and in adult mouse tissues.

  15. subset of integral membrane proteins, therefore, requires an early dislocation event to expose part of their luminal domain to the cytosol, before HRD1-mediated polyubiquitination and dislocation

  16. In Wnk1 knockout mice, levels of Lhx8 expression were reduced, inhibiting neural specification.

  17. WNK1 activation of the OSR1 signaling cascade is an essential pathway that regulates angiogenesis and cardiac formation during mouse embryo development.

  18. The findings supported the notion that WNK1 stimulates renal outer medullary potassium channel-mediated K+ secretion, but not flow-dependent K+ secretion mediated by maxi-K+ channels in cortical collecting ducts.

  19. The contribution of WNK1 to total WNK kinase activity in the kidney may be small, but that WNK1 may play a substantial role in the regulation of blood pressure in the arteries.

  20. The results evidenced a striking tissue-specific distribution of the different isoforms and the unexpected presence of exon HSN2 in many tissues other than the nervous system.

WNK1 Antigen-Profil

Protein Überblick

This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.

Genbezeichner und Symbole assoziert mit WNK1

  • WNK lysine deficient protein kinase 1 (WNK1) Antikörper
  • WNK lysine deficient protein kinase 1 L homeolog (wnk1.L) Antikörper
  • WNK lysine deficient protein kinase 1 (wnk1) Antikörper
  • serine/threonine-protein kinase WNK1 (LOC100056745) Antikörper
  • WNK lysine deficient protein kinase 1 (Wnk1) Antikörper
  • with no lysine (K) kinase 1 (WNK1) Antikörper
  • 6430573H23Rik Antikörper
  • ATWNK1 Antikörper
  • EG406236 Antikörper
  • hsan2 Antikörper
  • Hsn2 Antikörper
  • kdp Antikörper
  • mKIAA0344 Antikörper
  • p65 Antikörper
  • pha2c Antikörper
  • Prkwnk1 Antikörper
  • psk Antikörper
  • T9J14.14 Antikörper
  • T9J14_14 Antikörper
  • with no lysine (K) kinase 1 Antikörper
  • WNK1 Antikörper
  • ZIK4 Antikörper

Bezeichner auf Proteinebene für WNK1

WNK lysine deficient protein kinase 1 isoform , erythrocyte 65 kDa protein , prostate-derived sterile 20-like kinase , protein kinase with no lysine 1 , serine/threonine-protein kinase WNK1 , WNK lysine deficient protein kinase 1 , serine/threonine-protein kinase WNK1-like , protein kinase lysine-deficient 1

GENE ID SPEZIES
65125 Homo sapiens
406235 Sus scrofa
427925 Gallus gallus
451739 Pan troglodytes
477728 Canis lupus familiaris
506433 Bos taurus
706493 Macaca mulatta
734160 Xenopus laevis
100017207 Monodelphis domestica
100036683 Xenopus (Silurana) tropicalis
100056745 Equus caballus
100350906 Oryctolagus cuniculus
100436057 Pongo abelii
100594288 Nomascus leucogenys
232341 Mus musculus
116477 Rattus norvegicus
819651 Arabidopsis thaliana
100729855 Cavia porcellus
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