WD Repeat and FYVE Domain Containing 3 (WDFY3) ELISA Kits

WDFY3 encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. Zusätzlich bieten wir Ihnen WDFY3 Antikörper (68) und und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human WDFY3 WDFY3 23001 Q8IZQ1
Anti-Maus WDFY3 WDFY3 72145 Q6VNB8
Anti-Ratte WDFY3 WDFY3 305164  
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Weitere ELISA Kits für WDFY3 Interaktionspartner

Human WD Repeat and FYVE Domain Containing 3 (WDFY3) Interaktionspartner

  1. we demonstrate that normally ALFY attenuates the canonical Wnt (zeige WNT2 ELISA Kits) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 (zeige DVL3 ELISA Kits) and not of Dvl1 (zeige DVL1 ELISA Kits) or Dvl2 (zeige DVL2 ELISA Kits).

  2. ALFY binds selectively to LC3C and the GABARAPs through a LC3 (zeige MAP1LC3A ELISA Kits)-interacting region in its WD40 domain (zeige DCAF12L2 ELISA Kits).

  3. increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others

  4. Data suggest that p62 (zeige GTF2H1 ELISA Kits) and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy.

  5. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.

  6. Alfy might target cytosolic protein aggregates for autophagic degradation.

Mouse (Murine) WD Repeat and FYVE Domain Containing 3 (WDFY3) Interaktionspartner

  1. Data provide a novel association between WDFY3 and the RANKL (zeige TNFSF11 ELISA Kits)-induced osteoclastogenesis pathway via the modulation of TRAF6 (zeige TRAF6 ELISA Kits).

  2. Alfy translocalization likely is involved in the pathogenesis of amyotrophic lateral sclerosis.

  3. Wdfy3 is important in regulating neural progenitor divisions, neural migration, cerebral expansion and functional organization in the developing brain. Loss-of-function leads to pathological changes characteristic of autism spectrum disorders.

  4. gene expression profiling; in situ hybridization analysis revealed that the expressed BWF1 mRNA was restricted to the marginal region both in E14 and E16 (zeige SLC7A5 ELISA Kits) embryonic brain, but became diffuse after birth

WDFY3 Antigen-Profil

Beschreibung des Gens

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy.

Genbezeichner und Symbole assoziert mit WDFY3

  • WDFY family member 4 (WDFY4) Antikörper
  • WD repeat and FYVE domain containing 3 (WDFY3) Antikörper
  • WD repeat and FYVE domain-containing protein 3 (MGYG_03998) Antikörper
  • WD repeat and FYVE domain containing 3 (Wdfy3) Antikörper
  • 2610509D04Rik Antikörper
  • ALFY Antikörper
  • AW319683 Antikörper
  • B930017C24 Antikörper
  • Bchs Antikörper
  • BWF1 Antikörper
  • D5Ertd66e Antikörper
  • Ggtb3 Antikörper
  • mKIAA0993 Antikörper
  • ZFYVE25 Antikörper

Bezeichner auf Proteinebene für WDFY3

WD repeat and FYVE domain containing 3 , WD repeat and FYVE domain-containing protein 3 , autophagy-linked FYVE protein , beach domain, WD repeat and FYVE domain-containing protein 1 , galactosyltransferase 3 beta 1, 4

GENE ID SPEZIES
100157904 Sus scrofa
461201 Pan troglodytes
10029110 Arthroderma gypseum CBS 118893
422613 Gallus gallus
23001 Homo sapiens
487841 Canis lupus familiaris
537096 Bos taurus
72145 Mus musculus
305164 Rattus norvegicus
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