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WDR5 encodes a member of the WD repeat protein family. Zusätzlich bieten wir Ihnen WDR5 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal WDR5 Primary Antibody für ELISA, WB - ABIN969456
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Show all 2 Pubmed References
we found evidence that Setd1b (zeige SETD1B Antikörper), a maternally provided methyltransferase, is required for organizer gene expression. Our findings indicate that Wdr5-mediated H3K4 trimethylation plays a part in the organizer formation and dorsal axis development that are controlled by the maternal Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway.
The WDR5 is essential for vertebrate development, in that WDR5-depleted X. laevis tadpoles exhibit a variety of developmental defects and abnormal spatial Hox (zeige MSH2 Antikörper) gene expression.
we demonstrate for the first time that targeted expression of miR (zeige MLXIP Antikörper)-31-5p using a nonviral minicircle vector can serve as a novel approach for tumor miRNA therapy. Moreover, WDR5 may be a promising therapeutic target for NPC (zeige NPC1 Antikörper) treatment.
WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis
WDR5 functions to sustain proper execution of DNA replication in pancreatic ductal adenocarcinoma cells, as previously suggested by replication stress studies involving MLL1, and c-Myc (zeige MYC Antikörper), also found to interact with WDR5.
This report documents a novel lncRNA, GClnc1, which may act as a scaffold to recruit the WDR5 and KAT2A (zeige KAT2A Antikörper) complex and modify the transcription of target genes. This study reveals that GClnc1 is an oncogenic lncRNA in human gastric cancer.
WDR5 shows a direct binding to the ZNF407 (zeige ZNF407 Antikörper) promoter.
Taken together, these data suggest that WDR5 is directly involved in p53 (zeige TP53 Antikörper) signaling pathway. Our studies provide a new insight into WDR5 functions in A549 cells.
Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (zeige CAPS Antikörper) (WDR5) and Mixed Lineage Leukemia (MLL (zeige MLL Antikörper))/SET1 (zeige SETD1A Antikörper) Family Proteins Specifically Inhibits MLL1 and SETd1A (zeige SETD1A Antikörper) Methyltransferase Complexes.
WDR5 over-expression is associated with poor breast cancer clinical outcome.
Results identify WDR5 as a key cofactor for N-Myc (zeige MYCN Antikörper)-regulated transcriptional activation and tumorigenesis and as a novel therapeutic target for MYCN (zeige MYCN Antikörper)-amplified neuroblastomas.
BIG3 may block the KPNAs (KPNA1 (zeige KPNA1 Antikörper), KPNA5 (zeige KPNA5 Antikörper), and KPNA6 (zeige KPNA6 Antikörper)) binding region(s) of PHB2 (zeige PHB2 Antikörper).
Cbx8 (zeige CBX8 Antikörper) associates with non-PRC1 (zeige PRC1 Antikörper) complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch (zeige NOTCH1 Antikörper) gene expression.
Wdr5 suppression also reduced IFNgamma, Il-1beta (zeige IL1B Antikörper), and TNFalpha (zeige TNF Antikörper) induced chemokine (zeige CCL1 Antikörper) gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis
results suggest that specific RNAs are integral inputs into the WDR5-MLL (zeige MLL Antikörper) complex for maintenance of the active chromatin state and embryonic stem cell fates
Data show that broad association of myc proto-oncogene protein MYC (zeige MYC Antikörper) with chromatin depends on interaction with the WD40 (zeige DCAF12L2 Antikörper)-repeat protein WDR5.
BIG3 inhibits insulin (zeige INS Antikörper) granule biogenesis and insulin (zeige INS Antikörper) secretion.
BIG3 negatively regulates insulin (zeige INS Antikörper) granule exocytosis by restricting insulin (zeige INS Antikörper) granule biogenesis without the release kinetics of individual granules at the final exocytotic steps being affected.
Depletion of KAT2B (zeige KAT2B Antikörper) or WDR5 decreased gluconeogenic gene expression.
analysis of a novel mechanism for epigenetic control of SMC (zeige DYM Antikörper)-marker gene expression during development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes
Study shows that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (zeige MLLT1 Antikörper) (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal.
Characterization of a novel WDR5-binding site that recruits RbBP5 (zeige RBBP5 Antikörper) through a conserved motif to enhance methylation of histone H3 (zeige HIST3H3 Antikörper) lysine 4 by mixed lineage leukemia protein-1.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
WD repeat domain 5
, WD repeat-containing protein 5
, BMP2-induced 3-kb gene protein
, SWD3, Set1c WD40 repeat protein, homolog
, WD-repeat protein 5
, WD repeat-containing protein BIG-3