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PROC encodes a vitamin K-dependent plasma glycoprotein. Zusätzlich bieten wir Ihnen PROC Antikörper (216) und PROC Proteine (37) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) PROC ELISA Kit für Sandwich ELISA - ABIN415711
Kawasaki, Okamoto, Kawasaki, Sata: Thrombomodulin improved liver injury, coagulopathy, and mortality in an experimental heatstroke model in mice. in Anesthesia and analgesia 2014
Human PROC ELISA Kit für Competition ELISA - ABIN612753
Foster, Yoshitake, Davie: The nucleotide sequence of the gene for human protein C. in Proceedings of the National Academy of Sciences of the United States of America 1985
Show all 8 Pubmed References
Data show that activated protein C signals via protease activated receptors PAR2 (zeige F2RL1 ELISA Kits)/PAR3 (zeige F2RL2 ELISA Kits) to expand Treg cells, mitigating the disease in mice.
insulin (zeige INS ELISA Kits) and aPC (zeige APC ELISA Kits) converge on a common spliced-X-box binding protein-1 (zeige XBP1 ELISA Kits) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.
loss of the convertase furin (zeige FURIN ELISA Kits) or PC5 (zeige PCSK5 ELISA Kits)/6 in hepatocytes results in a approximately 30% decrease in APC (zeige APC ELISA Kits) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (zeige F2 ELISA Kits) activation.
APC (zeige APC ELISA Kits) modifies pulmonary fibrosis by limiting thrombin (zeige F2 ELISA Kits)-dependent macrophage recruitment.
Small interfering RNA-mediated silencing of protein C in apolipoprotein E (zeige APOE ELISA Kits)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.
These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (zeige APC ELISA Kits)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (zeige APC ELISA Kits) in the context of endotoxemia and infection
activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.
impaired EPCR (zeige PROCR ELISA Kits)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
SOD prevents thrombomodulin (zeige THBD ELISA Kits) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.
sPLA2 (zeige PLA2G2A ELISA Kits)-V plays a thrombogenic role by impairing the ability of EPCR (zeige PROCR ELISA Kits) to promote protein C activation.
The fusion protein recapitulates the functional and structural properties of the thrombin (zeige F2 ELISA Kits)-thrombomodulin (zeige THBD ELISA Kits) complex, prolongs the clotting time by generating pharmacological quantities of activated protein C and effectively diagnoses protein C deficiency in human plasma.
Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.
Laboratory tests and direct sequencing of PROC and SERPINC1 (zeige SERPINC1 ELISA Kits) were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin (zeige SERPINC1 ELISA Kits) deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in SERPINC1 (zeige SERPINC1 ELISA Kits) and a short deletion variant c.572_574delAGA in PROC.
Using protein C-factor VII (zeige TH ELISA Kits) chimera demonstrate that APC (zeige APC ELISA Kits) light chain amino acid residues outside the EPCR (zeige PROCR ELISA Kits)-binding site enable cytoprotective PAR1 signaling.
We recently identified a venous thrombosis patient whose plasma level of protein C antigen is normal, but its anticoagulant activity is only 34 % of the normal level. Genetic analysis revealed that the proband and her younger brother carry a novel heterozygous mutation c.346G>A, p.Gly74Ser (G74S) in PROC.
Developed functional protein S assays that measure both the activated protein C- and TFPI (zeige TFPI ELISA Kits)-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation.
Protein C seems inversely associated with mortality in patients with advanced prostate, lung and pancreatic cancer. Further research should validate protein C as a biomarker for mortality, and explore the effects of protein C on progression of cancer.
Genetically higher protein C was associated with a lower risk of ischaemic heart disease.
EPCR (zeige PROCR ELISA Kits) occupancy recruits G-protein coupled receptor kinase 5 (zeige GRK5 ELISA Kits), thereby inducing beta-arrestin-2 (zeige ARRB2 ELISA Kits) biased PAR1 signaling by both APC (zeige APC ELISA Kits) and thrombin (zeige F2 ELISA Kits). In
A novel mutation of A309V in PROC was determined in a family of two patients with late onset protein C deficiency
Activated protein c is a ghrelin (zeige GHRL ELISA Kits) endopeptidase.
Activated protein C(APC (zeige APC ELISA Kits)) combined with protein S(PS) had significant antithrombotic effect. APC (zeige APC ELISA Kits) combined with PS prolonged clotting time. Dependence on APC (zeige APC ELISA Kits)-cofactor activity of PS for expression of anticoagulant activity by APC (zeige APC ELISA Kits).
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
, anticoagulant protein C
, vitamin K-dependent protein C
, protein C (inactivator of coagulation factors Va and VIIIa)
, vitamin K-dependent protein C-like
, autoprothrombin IIA
, blood coagulation factor XIV
, inactivator of coagulation factors Va, VIII
, catalytic region
, protein C (precursor of vitamin K-dependent serine protease)