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VIPR1 encodes a receptor for vasoactive intestinal peptide, a small neuropeptide.
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In vitro-polarized macrophages by GM-CSF (zeige CSF2 ELISA Kits) (GM-MO), with a proinflammatory profile, expressed higher levels of VIP (zeige Vip ELISA Kits) receptors, vasoactive intestinal polypeptide (zeige Vip ELISA Kits) receptors 1 and 2 (VPAC1 and VPAC2 (zeige VIPR2 ELISA Kits), respectively), than macrophages polarized by M-CSF (zeige CSF1 ELISA Kits) (M-MO) with anti-inflammatory activities. RA synovial macrophages, according to their GM-CSF (zeige CSF2 ELISA Kits)-like polarization state, expressed both VPAC1 and VPAC2 (zeige VIPR2 ELISA Kits).
VPAC1 rs9677 CC genotype could be correlated with a reduced response to statin therapy and seems to be involved in diabetes cardiomyopathy in female patients with type 2 diabetes.
The results reveal that more severe inflammation, based on high levels of IL-6 (zeige IL6 ELISA Kits), is associated with lower expression of VPAC1 and, conversely, with increased expression of VPAC2 (zeige VIPR2 ELISA Kits).
variations at the 3'UTR (zeige UTS2R ELISA Kits) of the VPAC-1 gene act synergistically to affect the expression of the luciferase as well as of the GFP reporter genes expressed in HEK293T cells.
These data suggest that VPAC1 overexpression is associated with poorer differentiation of colon cancer, which is likely caused by subsequent EGFR (zeige EGFR ELISA Kits) activation in cancer cells.
VIP (zeige Vip ELISA Kits) regulates CFTR (zeige CFTR ELISA Kits) membrane expression and function in Calu (zeige CALU ELISA Kits)-3 cells by increasing its interaction with NHERF1 and P-ERM in a VPAC1- and PKCepsilon (zeige PRKCE ELISA Kits)-dependent manner.
VPAC1 receptor has a role in endotoxemia in peripheral blood mononuclear cells
The overexpression of VPAC1 and VPAC2 (zeige VIPR2 ELISA Kits) receptors and COX-2 (zeige COX2 ELISA Kits) in cancer tissue gives them a potential role as targets for diagnosis of prostate cancer.
hree residues play an important role in VPAC1 interaction with the first histidine residue of VIP (zeige Vip ELISA Kits). These data demonstrate that VIP (zeige Vip ELISA Kits) and PG97-269 bind to distinct domains of VPAC1
The genetic association reported here indicates that VIP (zeige Vip ELISA Kits)/VPAC1 signaling can be a relevant pathway in the pathogenesis of type 2 diabetes in females
This study demonstrated that VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage.
VPAC1R mRNA expression was significantly decreased 3 days after ischemia induced by bilateral common carotid artery occlusion
Cyclophosphamide-induced cystitis decreased VPAC1 receptor transcript expression in the urothelium of WT (4 h, 48 h, & chronic) & NGF (zeige NGFB ELISA Kits)-OE mice.
Data support the notion that both VPAC1 and VPAC2 (zeige VIPR2 ELISA Kits) receptors are dynamically regulated by Ikaros (zeige IKZF1 ELISA Kits), a master transcriptional regulator for thymocyte differentiation, during early thymic development.
results support that decline in VIP (zeige Vip ELISA Kits)/VPAC local levels may influence survival/apoptosis intracellular set point in NOD acinar cells and their clearance, contributing to gland homeostasis loss in a model of Sjogren's syndrome
Homozygous deletion of VPAC1 resulted in fetal, neonatal, and postweaning death owing to failure to thrive, intestinal obstruction, and hypoglycemia.
VIP (zeige Vip ELISA Kits) enhancement of the severity of dextran sodium sulfate-induced colitis is mediated solely by VPAC1 receptors in mice.
Data describe PACAP (zeige ADCYAP1 ELISA Kits), vasoactive intestinal polypeptide (zeige Vip ELISA Kits), and PAC1 (zeige ADCYAP1R1 ELISA Kits), VPAC1, VPAC2 (zeige VIPR2 ELISA Kits) transcripts or protein expression in urothelium and detrusor smooth muscle and lumbosacral dorsal root ganglia in NGF (zeige NGFB ELISA Kits)-overexpressing and wildtype mice.
VPAC(1)-R activation aggravates atherosclerotic lesion formation in apolipoprotein E (zeige APOE ELISA Kits)-deficient mice through enhanced inflammatory activity in the vessel wall.
VIP (zeige Vip ELISA Kits) and its receptors (VPAC1, VPAC2 (zeige VIPR2 ELISA Kits)) were identified in type II taste cells of the taste bud, and VIP (zeige Vip ELISA Kits) knockout mice exhibit enhanced taste preference to sweet tastants.
Implanting vascular bundles into the tissue engineered bone can significantly improve the expression levels of NK1R (zeige TACR1 ELISA Kits) and VIPR1.
The study confirmed the presence of VPAC1 receptor in the tissues of the porcine female reproductive tract what clearly shows the possibility of influence of vasoactive intestinal polypeptide (zeige Vip ELISA Kits) on the porcine ovary, oviduct and uterus.
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene.
PACAP type II receptor
, VIP and PACAP receptor 1
, VIP receptor, type I
, pituitary adenylate cyclase activating polypeptide receptor, type II
, vasoactive intestinal polypeptide receptor 1
, VIP receptor subtype 1
, pituitary adenylate cyclase-activating polypeptide type II receptor
, Vasopressive intestinal peptide receptor
, vasoactive intestinal peptide receptor 1
, vasoactive intestinal polypeptide receptor 1-like
, vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide receptor 1
, vpac1 receptor
, vasoactive intestinal polypeptide receptor type 1
, VIP receptor
, Vasoactive intestinal polypeptide receptor