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SRC is highly similar to the v-src gene of Rous sarcoma virus. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Results suggest that Src promotes EGF (zeige EGF Antikörper)-stimulated EMT (zeige ITK Antikörper) and migration by upregulation of ZEB1 (zeige ZEB1 Antikörper) and ZEB2 (zeige ZEB2 Antikörper) through AKT (zeige AKT1 Antikörper) signaling pathway in gastric cancer cells.
Combined targeting of AKT (zeige AKT1 Antikörper) and SRC resulted in a synergistic efficacy against human pancreatic cancer growth and metastasis.
important roles for c-Src tyrosine kinase (zeige CSK Antikörper) in phosphorylation and activation of SLC11A1 (zeige SLC11A1 Antikörper) in macrophages
Our data suggest that targeting Src signaling may be an effective approach to the treatment of ALK-non-small cell lung cancer (NSCLC) with acquired resistance to ALK inhibitors.
Src kinase (zeige CSK Antikörper) in chemo-naive human primary osteosarcoma cells is differentially activated.
This study demonstrates that simultaneous inhibition of c-Met and Src signaling in MD-MSCs triggers apoptosis and reveals vulnerable pathways that could be exploited to develop NF2 (zeige NF2 Antikörper) therapies.
Syntenin (zeige SDCBP Antikörper) mediates SRC function in exosomal cell-to-cell communication.
Endothelial cell-derived matrix promotes the metabolic functional maturation of hepatocyte via integrin-Src signaling.
The expression of Src under the influence of nilotinib, dasatinib, erlotinib, gefitinib and afatinib was studied in HPV-positive head and neck squamous cell carcinomas. Src expression was significantly increased by all tested tyrosine kinase (zeige TXK Antikörper) inhibitors.
Multivariate Cox (zeige COX8A Antikörper) regression analysis suggested that PTPRA (zeige PTPRA Antikörper) expression was an independent prognostic factor in SCC (zeige CYP11A1 Antikörper) patients. In the cellular models, PTPRA (zeige PTPRA Antikörper) promotes SCC (zeige CYP11A1 Antikörper) cell proliferation through modulating Src activation as well as cell cycle progression. In conclusion, higher PTPRA (zeige PTPRA Antikörper) level was associated with worse prognosis of SCC (zeige CYP11A1 Antikörper) patients and PTPRA (zeige PTPRA Antikörper) could promote the cell cycle progression
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
, proto-oncogene tyrosine-protein kinase Src
, protooncogene SRC, Rous sarcoma
, tyrosine kinase pp60c-src
, tyrosine-protein kinase SRC-1