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SRC is highly similar to the v-src gene of Rous sarcoma virus.
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Syntenin (zeige SDCBP Antikörper) mediates SRC function in exosomal cell-to-cell communication.
Endothelial cell-derived matrix promotes the metabolic functional maturation of hepatocyte via integrin-Src signaling.
The expression of Src under the influence of nilotinib, dasatinib, erlotinib, gefitinib and afatinib was studied in HPV-positive head and neck squamous cell carcinomas. Src expression was significantly increased by all tested tyrosine kinase (zeige TXK Antikörper) inhibitors.
Multivariate Cox (zeige COX8A Antikörper) regression analysis suggested that PTPRA (zeige PTPRA Antikörper) expression was an independent prognostic factor in SCC (zeige CYP11A1 Antikörper) patients. In the cellular models, PTPRA (zeige PTPRA Antikörper) promotes SCC (zeige CYP11A1 Antikörper) cell proliferation through modulating Src activation as well as cell cycle progression. In conclusion, higher PTPRA (zeige PTPRA Antikörper) level was associated with worse prognosis of SCC (zeige CYP11A1 Antikörper) patients and PTPRA (zeige PTPRA Antikörper) could promote the cell cycle progression
c-Src/MAPK (zeige MAPK1 Antikörper)/NF-kB signaling pathway may contribute to the pathogenesis of pre-eclampsia
Data indicate the role of tyrosine kinase (zeige TXK Antikörper) c-Src (Src) in rescuing Taz (transcriptional coactivator with PDZ-binding motif (zeige WWTR1 Antikörper)) from E3 ligase SCF (zeige KITLG Antikörper)(beta-TrCP (zeige BTRC Antikörper))-mediated degradation.
Data suggest that response of bronchial epithelial cells to environmental carcinogen benzo[a]pyrene includes activation of AhR/Src/ERK signaling, CYP1A1 induction, and formation of stable DNA adducts. (AhR = aryl hydrocarbon receptor; Src = Src proto-oncogene kinase; ERK = extracellular signal-regulated kinases; CYP1A1 = cytochrome P450 family 1 subfamily A member 1)
It is unclear if we may have seen greater clinical activity if we were able to fully inhibit Src in this study, but given the requirement that enrolling patients have documented disease progression on cetuximab, acquired resistant KRAS-mutant clones may have been present, limiting future strategies to reverse EGFR (zeige EGFR Antikörper) resistance
this study shows that simultaneous deactivation of FAK (zeige PTK2 Antikörper) and Src improves the pathology of hypertrophic scar
mutations in the germline and somatic DNA of the TEK (zeige TEK Antikörper) gene were identified and analyze the expression level of Src and phospho-Src (p-Src) in tumor and healthy tissues from patients with facial cutaneo-mucosal venous malformations.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
, proto-oncogene tyrosine-protein kinase Src
, protooncogene SRC, Rous sarcoma
, tyrosine kinase pp60c-src
, tyrosine-protein kinase SRC-1