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UMOD encodes uromodulin, the most abundant protein in normal urine. Zusätzlich bieten wir Ihnen Uromodulin Antikörper (183) und Uromodulin Proteine (21) und viele weitere Produktgruppen zu diesem Protein an.
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Rat (Rattus) Uromodulin ELISA Kit für Sandwich ELISA - ABIN436598
Wang, Pan, Hong, Zhang, Wang, Kong: Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats. in Evidence-based complementary and alternative medicine : eCAM 2012
Show all 2 Pubmed References
Human Uromodulin ELISA Kit für Sandwich ELISA - ABIN2703552
Cassidy, Slyne, OKelly, Traynor, Conlon, Johnston, Slattery, Ryan, McMorrow: Urinary biomarkers of chronic allograft nephropathy. in Proteomics. Clinical applications 2015
UMOD gene variants in humans fulfill the criteria for ascribing a gene as causal of Hypertension.
The missense mutation p.142R>R/Q in the uromodulin gene in patients with cast Nephropathy in Multiple Myeloma.
Data show that one SNP (rs183962941), located in a non-coding region of uromodulin protein (UMOD), was nominally associated with end-stage renal disease (ESRD).
THP appears to participate directly in complement inactivation by its ability to act as a cofactor for C3b degradation.
High urinary uromodulin levels are associated with lower risk for UTI (zeige AMBP ELISA Kits) in older community-dwelling adults independent of traditional UTI (zeige AMBP ELISA Kits) risk factors.
The uromodulin-CFH (zeige CFH ELISA Kits) interaction enhanced the cofactor activity of CFH (zeige CFH ELISA Kits) for factor I-mediated cleavage of C3b to inactivated C3b.
These findings suggest that the levels of urinary microvesicle-bound uromodulin are associated with the severity of diabetic kidney disease.
Data strongly suggest that the uromodulin ancestral allele, driving higher urinary excretion of uromodulin, has been kept at a high frequency because of its protective effect against urinary tract infections
The frequency of uromodulin single nucleotide polymorphism rs13333226 GG/GA genotype was significantly higher and the frequency of G allele was much higher in the patients with end stage renal disease than in the controls.
Serum uromodulin concentrations are closely correlated with estimated glomerular filtration rate, which is the recommended measure of renal function. As uromodulin is produced exclusively by renal tubular cells, the assessment of uromodulin levels in patients with chronic kidney disease may be an alternative method for evaluating the number of functioning nephrons.
results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses
Endoplasmic reticulum stress and apoptosis are key features in a mouse model of kidney disease driven by the uromodulin p.Cys147Trp mutation.
Consistently, pathway enrichment analysis indicates that mutant uromodulin expression affects ER function and protein homeostasis.
we show that Tamm-Horsfall protein deficiency stimulates proximal epithelial activation of the Interleukin-23/Interleukin-17 (zeige IL17A ELISA Kits) axis and systemic neutrophilia.
TNFalpha (zeige TNF ELISA Kits) regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha (zeige TNF ELISA Kits) on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta (zeige HNF1B ELISA Kits)-mediated expression of uromodulin.
AGP (zeige USMG5 ELISA Kits) was more effective in limiting hepatic inflammation and maintaining perfusion than saline or HAS, in both endotoxemic and septic mice. AGP (zeige USMG5 ELISA Kits) sequestration of LPS (zeige TLR4 ELISA Kits) may contribute to its anti-inflammatory effects.
UMOD upregulates TRPV5 (zeige TRPV5 ELISA Kits) by decreasing caveolin-1 (zeige CAV1 ELISA Kits) dependent endocytosis of TRPV5 (zeige TRPV5 ELISA Kits).
UMOD regulates sodium uptake in the thick ascending limb of the loop of Henle by modulating the effect of tumor necrosis factor-alpha (zeige TNF ELISA Kits) on NKCC2A expression, making UMOD an important determinant of blood pressure control.
Genetic susceptibility link to hypertension and chronic kidney disease to uromodulin expression and uromodulin's effect on salt reabsorption in the kidney.
Using an ischemia-reperfusion model of murine acute kidney injury, we show that, while THP expression in thick ascending loop is downregulated at the peak of injury, it is significantly upregulated 48 h after.
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
, Tamm-Horsfall urinary glycoprotein
, tamm-Horsfall urinary glycoprotein
, uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
, Urmodulin (Tamm-Horsfall protein)
, uromucoid, human : Tamm-Horsfall glycoprotein