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UMOD encodes uromodulin, the most abundant protein in normal urine. Zusätzlich bieten wir Ihnen Uromodulin Antikörper (192) und Uromodulin Proteine (23) und viele weitere Produktgruppen zu diesem Protein an.
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Rat (Rattus) Uromodulin ELISA Kit für Sandwich ELISA - ABIN436598
Wang, Pan, Hong, Zhang, Wang, Kong: Quercetin Protects against Cadmium-Induced Renal Uric Acid Transport System Alteration and Lipid Metabolism Disorder in Rats. in Evidence-based complementary and alternative medicine : eCAM 2012
Show all 2 Pubmed References
Mouse (Murine) Uromodulin ELISA Kit für Sandwich ELISA - ABIN429854
Cho, Song, Oh, Kim, Ko, Lee, Jo: Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury. in Journal of Korean medical science 2017
Human Uromodulin ELISA Kit für Sandwich ELISA - ABIN2703552
Cassidy, Slyne, OKelly, Traynor, Conlon, Johnston, Slattery, Ryan, McMorrow: Urinary biomarkers of chronic allograft nephropathy. in Proteomics. Clinical applications 2015
The frequency of UMOD rs4293393 variant with C allele was significantly higher in individuals with iabetic nephropathy . UMOD rs4293393 T>C variation might have a bearing on susceptibility to nephropathy in north Indian individuals with type 2 diabetes.
these data support THP as an important negative regulator of neutrophil activation in the urinary tract, with dual functions to counteract bacterial colonization and suppress excessive inflammation within the urinary tract
Homozygous UMOD mutation did not show a strikingly more severe clinical evolution nor was the near absence of urinary uromodulin associated with urinary tract infections or kidney stones.
we report a novel UMOD mutation in a Brazilian family with 11 affected members, and we discuss the importance of performing genetic testing in families with inherited kidney disease of unknown cause.
Studied genetic association of uromodulin SNP in kidney function of patients with hypertension and cardiovascular disease.
Single-nucleotide polymorphism in UMOD gene is associated with type 2 diabetes.
UMOD gene variants in humans fulfill the criteria for ascribing a gene as causal of Hypertension.
The missense mutation p.142R>R/Q in the uromodulin gene in patients with cast Nephropathy in Multiple Myeloma.
Data show that one SNP (rs183962941), located in a non-coding region of uromodulin protein (UMOD), was nominally associated with end-stage renal disease (ESRD).
THP appears to participate directly in complement inactivation by its ability to act as a cofactor for C3b degradation.
this study shows that uromodulin-SlpA (zeige SEPT9 ELISA Kits) binding dictates Lactobacillus acidophilus uptake by intestinal epithelial M cells
results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses
Endoplasmic reticulum stress and apoptosis are key features in a mouse model of kidney disease driven by the uromodulin p.Cys147Trp mutation.
Consistently, pathway enrichment analysis indicates that mutant uromodulin expression affects ER function and protein homeostasis.
we show that Tamm-Horsfall protein deficiency stimulates proximal epithelial activation of the Interleukin-23/Interleukin-17 (zeige IL17A ELISA Kits) axis and systemic neutrophilia.
TNFalpha (zeige TNF ELISA Kits) regulates uromodulin expression in a homeostatic setting, but the impact of TNFalpha (zeige TNF ELISA Kits) on uromodulin during kidney injury is superseded by other factors that could inhibit HNF1beta (zeige HNF1B ELISA Kits)-mediated expression of uromodulin.
AGP was more effective in limiting hepatic inflammation and maintaining perfusion than saline or HAS, in both endotoxemic and septic mice. AGP sequestration of LPS may contribute to its anti-inflammatory effects.
UMOD upregulates TRPV5 (zeige TRPV5 ELISA Kits) by decreasing caveolin-1 (zeige CAV1 ELISA Kits) dependent endocytosis of TRPV5 (zeige TRPV5 ELISA Kits).
UMOD regulates sodium uptake in the thick ascending limb of the loop of Henle by modulating the effect of tumor necrosis factor-alpha (zeige TNF ELISA Kits) on NKCC2A expression, making UMOD an important determinant of blood pressure control.
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
, Tamm-Horsfall urinary glycoprotein
, tamm-Horsfall urinary glycoprotein
, uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
, Urmodulin (Tamm-Horsfall protein)
, uromucoid, human : Tamm-Horsfall glycoprotein