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The protein encoded by USP18 belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. Zusätzlich bieten wir Ihnen USP18 Proteine (4) und USP18 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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this study identified PTEN as a previously unrecognized substrate of the ISGylation post-translational modification pathway. The deconjugase USP18 serves as a novel regulator of PTEN stability. This indicates inhibition of ISGylation is therapeutically relevant in cancers.
associates with and deubiquitinates TAK1 (zeige MAP3K7 Antikörper) to protect against hepatic steatosis, insulin (zeige INS Antikörper) resistance, and the inflammatory response
that Ubiquitin-specific peptidase 18 directly bind to BCL2L1 (zeige BCL2L1 Antikörper) and positively regulated its expression in hepatocellular carcinoma cells
These findings add USP18 deficiency to the list of genetic disorders collectively termed type I interferonopathies
We show that IRF-7 (zeige IRF7 Antikörper) siRNA knockdown enhanced LPS (zeige IRF6 Antikörper)-induced IL-10 (zeige IL10 Antikörper) production in human monocyte-derived macrophages, and USP-18 overexpression attenuated LPS (zeige IRF6 Antikörper)-induced production of IL-10 (zeige IL10 Antikörper) in RAW264.7 cells. Quantitative PCR confirmed upregulation of USP18, USP41, IL10 (zeige IL10 Antikörper), and IRF7 (zeige IRF7 Antikörper). An independent cohort confirmed LPS (zeige IRF6 Antikörper) induction of USP41 and IL10 (zeige IL10 Antikörper) genes
results indicated that USP18 modulates the anti-HBV activity of IFN-F via activation of the JAK (zeige JAK3 Antikörper)/STAT (zeige STAT1 Antikörper) signaling pathway in Hepg2.2.15 cells.
USP18's ISG15 (zeige ISG15 Antikörper) specificity is mediated by a small interaction interface.
STAT2 (zeige STAT2 Antikörper) recruits USP18 to the type I IFN receptor subunit IFNAR2 (zeige IFNAR2 Antikörper) via its constitutive membrane-distal STAT2 (zeige STAT2 Antikörper)-binding site.
findings show that multiple inflammatory stimuli can modulate interferon (zeige IFNA Antikörper) stimulated gene expression and thus inhibit hepatocyte interferon (zeige IFNA Antikörper) signaling via USP18 induction
USP18 negatively regulates NF-kappaB (zeige NFKB1 Antikörper) signaling by targeting TAK1 (zeige MAP3K7 Antikörper) and NEMO (zeige IKBKG Antikörper) for deubiquitination through distinct mechanisms.
These data highlight USP18 as a host restriction factor during innate immune response to porcine respiratory and reproductive syndrome virus.
USP18 is a potential target gene that promotes reduced replication of PRRSV.
Results report identification and cloning of the ISG15 (zeige ISG15 Antikörper) and ISG43 genes in pig.
associates with and deubiquitinates TAK1 (zeige NR2C2 Antikörper) to protect against hepatic steatosis, insulin (zeige INS Antikörper) resistance, and the inflammatory response
this study identifies the osteopenia phenotype of mice lacking Usp18, which is known as a negative regulator of type I IFN signaling
USP18 has a protective role in pathological cardiac remodeling in mouse.
Increased ISGylation was accompanied by enhanced viral resistance without causing detrimental side effects suggesting that USP18 protease inhibition might be a suitable antiviral strategy
USP18 null mice develop leiomyosarcoma recapitulating key features of clinical leiomyosarcomas and patients with reduced-USP18 tumor levels have an unfavorable outcome.
USP18 lack in microglia causes destructive interferonopathy of the mouse brain.
results suggest that increasing ISGylation by specific inhibition of USP18 protease activity could constitute a promising antiviral strategy with only a minimal risk of severe adverse effects
USP18 is crucial for IFN-gamma (zeige IFNG Antikörper)-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity.
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.
ubl carboxyl-terminal hydrolase 18
, ubiquitin specific peptidase 18
, universal stress protein
, ubiquitin specific protease 18
, ubiquitin specific peptidase 41
, 43 kDa ISG15-specific protease
, ISG15-specific-processing protease
, ubl thioesterase 18
, ubl thiolesterase 18
, interferon-stimulated gene 43
, ubiquitin-specific protease 18
, ubiquitin specific protease 15