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Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Zusätzlich bieten wir Ihnen USP13 Proteine (3) und und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal USP13 Primary Antibody für ICC, IF - ABIN4364543
Cheung, Yang, Lee, Rennert, Chan: Hypermethylation of genes in testicular embryonal carcinomas. in British journal of cancer 2016
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Human Polyclonal USP13 Primary Antibody für ELISA, WB - ABIN545123
DAndrea, Pellman: Deubiquitinating enzymes: a new class of biological regulators. in Critical reviews in biochemistry and molecular biology 1999
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Human Polyclonal USP13 Primary Antibody für IHC (p), ELISA - ABIN545124
Timms, Ansari-Lari, Morris, Brown, Gibbs: The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP). in Gene 1998
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USP13 is a regulator of DNA repair.USP13 regulates RAP80-BRCA1 complex foci formation.The role of USP13 in the neoplasm drug resistance.
These results reveal an important metabolism-centric role of USP13, which may lead to potential therapeutics targeting USP13 in ovarian cancers.
in the samples of 293T cell lines after the overexpression of USP13 and USP13 C345S, vinculin exhibited an increased expression, suggesting that it may be a candidate substrate of USP13.
Deubiquitinating enzyme 13 (USP13) regulates myeloid cell leukemia sequence 1 protein (MCL1) stability in lung and ovarian cancer cells.
our results demonstrate that AR can promote melanoma metastasis via altering the miRNA-539-3p/USP13/MITF/AXL signal and targeting this newly identified signal with AR degradation enhancer ASC-J9 may help us to better suppress the melanoma metastasis.
USP13 and FBXL14 play opposing roles in the regulation of glioma stem cells (GSCs) through reversible ubiquitination of c-Myc.
Down-regulation of USP13 mediates PTEN protein loss and fibroblast phenotypic change, and thereby plays a crucial role in idiopathic pulmonary fibrosis pathogenesis.
The authors identify USP13 as a gp78-associated deubiquitinase that eliminates ubiquitin conjugates from Ubl4A to maintain the functionality of Bag6.
USP13 is a tumour-suppressing protein that functions through deubiquitylation and stabilization of PTEN.
to our knowledge, USP13 is the first deubiquitinating enzymes identified to modulate STAT1 and play a role in the antiviral activity of IFN against DEN-2 replication.
USP10 mediates the deubiquitination of p53, regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53.
Through deubiquitination, USP13 stabilizes and upregulates MITF protein levels.
study identifies a new layer of Siah2 regulation mediated by USP13 binding to ubiquitinated Siah2 protein with a concomitant inhibitory effect on its activity under normoxia
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro\; however, additional experiments are required to confirm such data (By similarity).
deubiquitinating enzyme 13
, isopeptidase T-3
, ubiquitin carboxyl-terminal hydrolase 13
, ubiquitin specific protease 13 (isopeptidase T-3)
, ubiquitin thioesterase 13
, ubiquitin thiolesterase 13
, ubiquitin-specific-processing protease 13
, ubiquitin specific peptidase 13 (isopeptidase T-3)
, ubiquitin carboxyl-terminal hydrolase 13-like
, ubiquitin thiolesterase 13-like
, Deubiquitinating enzyme 13
, Ubiquitin thioesterase 13
, Ubiquitin-specific-processing protease 13
, ubiquitin specific peptidase 13
, universal stress protein