Ubiquitin Protein Ligase E3C Proteine (UBE3C)

E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Zusätzlich bieten wir Ihnen UBE3C Antikörper (23) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte UBE3C UBE3C 362294  
Maus UBE3C UBE3C 100763 Q80U95
UBE3C 9690 Q15386
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$12,127.90
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$860.20
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UBE3C Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Weitere Proteine zu Ubiquitin Protein Ligase E3C (UBE3C) Interaktionspartnern

Mouse (Murine) Ubiquitin Protein Ligase E3C (UBE3C) Interaktionspartner

  1. Usp14 and Ube3c cycle together on and off proteasomes, and the presence of ubiquitinated substrates promotes their association. This mechanism enables proteasome activity to adapt to the supply of substrates.

Human Ubiquitin Protein Ligase E3C (UBE3C) Interaktionspartner

  1. miR (zeige MLXIP Proteine)-542-3p functioned as a tumor suppressor gene in regulating the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via targeting UBE3C.

  2. Usp14 and Ube3c cycle together on and off proteasomes, and the presence of ubiquitinated substrates promotes their association. This mechanism enables proteasome activity to adapt to the supply of substrates.

  3. UBE3C promotes melanoma progression, possibly by inducing epithelial-mesenchymal transition in melanoma cells

  4. Ectopic overexpression of UBE4A, but not UBE3C, in cells was downregulated in vitro migration and invasion in these cells. Cumulatively, our data reveals a novel post-translational regulatory mechanism of regulating ILEI1 expression, a protein required for metastatic progression in prostate cancer cells

  5. data reveal that high UBE3C expression contributes to glioma progression by ubiquitination and degradation of ANXA7 (zeige ANXA7 Proteine), and thus presents a novel and promising target for glioma therapy.

  6. these observations suggest that UBE3C plays an important role in RCC (zeige XRCC1 Proteine) development and progression, and UBE3C may be a novel target for prevention and treatment of ccRCC.

  7. UBE3C is a mutant candidate oncogene (zeige RAB1A Proteine) involved in tumor development and progression of hepatocellular carcinoma.

  8. knockdown renders cells more susceptible to the Hsp90 (zeige HSP90 Proteine) inhibitor 17-AAG (zeige MPG Proteine), suggesting that UBE3C protects against the harmful accumulation of protein fragments arising from incompletely degraded proteasome substrates.

  9. Our findings provide evidence that variations in UBE3C are potent genetic markers of nasal polyps development in Korean asthmatics.

  10. negatively regulates type I interferon (zeige IFNA Proteine) through ubiquitination of the transcription factors

UBE3C Protein Überblick

Protein Überblick

E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.

Genbezeichner und Symbole assoziert mit UBE3C

  • ubiquitin protein ligase E3C (UBE3C)
  • ubiquitin protein ligase E3C (Ube3c)
  • ubiquitin protein ligase E3C (ube3c)
  • ubiquitin protein ligase E3C S homeolog (ube3c.S)
  • AI853514 Protein
  • HECTH2 Protein
  • kiaa0010 Protein
  • MGC146390 Protein
  • mKIAA0010 Protein
  • RGD1559986 Protein
  • UBE3C Protein
  • zgc:63649 Protein

Bezeichner auf Proteinebene für UBE3C

ubiquitin-protein ligase E3C , ubiquitin protein ligase E3C , ubiquitin-protein isopeptide ligase (E3) , ubiquitin-protein ligase E3C-like

GENE ID SPEZIES
508513 Bos taurus
482822 Canis lupus familiaris
719956 Macaca mulatta
472637 Pan troglodytes
362294 Rattus norvegicus
393445 Danio rerio
100763 Mus musculus
420447 Gallus gallus
9690 Homo sapiens
380493 Xenopus laevis
779973 Xenopus (Silurana) tropicalis
100016776 Monodelphis domestica
100228118 Taeniopygia guttata
100475169 Ailuropoda melanoleuca
100547787 Meleagris gallopavo
100723450 Cavia porcellus
101925366 Macaca fascicularis
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