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Plays a role in the regulation of proteasomal protein degradation. Zusätzlich bieten wir Ihnen UBQLN4 Proteine (2) und viele weitere Produktgruppen zu diesem Protein an.
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Here, the authors present a novel variant in UBQLN4 that is associated with ALS and show that its expression compromises motor axon morphogenesis in mouse motor neurons and in zebrafish.
UBQLN4, APP (zeige APP Antikörper), CTNNB1 (zeige CTNNB1 Antikörper), SHBG (zeige SHBG Antikörper), and COL1A1 (zeige COL1A1 Antikörper) might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition
UBQLN4 recognizes not only the defective model substrate but also a pool of endogenous defective proteins that were induced by the depletion of the SRP54 subunit of the signal recognition particle.
results suggested that CIP75 is essential for the interaction of Cx43 (zeige GJA1 Antikörper) and the proteasome, but that alternate compensatory mechanisms exist to supplement the degradation normally facilitated by CIP75
Targeting of Ubqln1 (zeige UBQLN1 Antikörper) to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 (zeige UBQLN1 Antikörper) UBA domain.
although CIP75 can interact with ubiquitinated cellular proteins, its interaction with Cx43 (zeige GJA1 Antikörper) and stimulation of Cx43 (zeige GJA1 Antikörper) proteasomal degradation does not require the ubiquitination of Cx43 (zeige GJA1 Antikörper).
Co-immunoprecipitation confirmed the binding of small hydrophobic (SH) protein of mumps virus and ubiquilin 4 and demonstrates that a truncated protein fragment corresponding to amino acids 136-270 of ubiquilin 4 was sufficient for interaction.
A novel connexin43 (zeige GJA1 Antikörper)-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43 (zeige GJA1 Antikörper)
Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation.
, ubiquilin 4
, ataxin-1 ubiquitin-like interacting protein
, ataxin-1 interacting ubiquitin-like protein
, ataxin-1 ubiquitin-like-interacting protein A1U
, connexin43-interacting protein of 75 kDa