anti-UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) Antikörper

UPF1 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Zusätzlich bieten wir Ihnen UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
UPF1 5976 Q92900
UPF1 19704 Q9EPU0
UPF1 684558  
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Top anti-UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Antikörper auf antikoerper-online.de

Showing 10 out of 64 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Ziege Unkonjugiert WB Detection of Human RENT1 by Western Blot. Samples: Whole cell lysate (30 mcg) from lymphoblastoid cell lines (EBV-immotalized B-cell from a normal individual). Antibody: Affinity purified goat anti-RENT1 antibody ABIN151832 used at 1 mcg/ml. Detection: Chemiluminescence. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Ziege Unkonjugiert PLA, WB Western Blot: RENT-1 Antibody [ABIN151834] - Detection of Human RENT-1 by Western Blot. Samples: Whole cell lysate (30 mcg) from lymphoblastoid cell lines (EBVimmotalized B-cell from a normal individual). Antibody: Affinity purified goat anti-RENT-1 antibody (Cat. No. ABIN151834) used at 1 mcg/ml. Detection: Chemiluminescence. Proximity Ligation Assay: RENT1/UPF1/hUPF1 Antibody [ABIN151834] - Secondary-conjugate Duolink II PLA in Hela cells. Goat anti-human RENT1 (ABIN151834) and rabbit anti-human ATR (ABIN151834). Image merged from DAPI (2ms) and Texas Red (200ms) exposoures, 40X magnification. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Kaninchen Unkonjugiert IHC (p), WB 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of RENT1 (arrow) using rabbit polyclonal RENT1 Antibody (N-term) (ABIN388607). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the RENT1 gene (Lane 2) (Origene Technologies). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from K562/HeLa cells, using UPF1 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using UPF1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IF, IHC, WB Immunohistochemistry of paraffin-embedded mouse heart using UPF1 antibody at dilution of 1:100 (x40 lens). 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Kaninchen Unkonjugiert EIA 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of RENT1 (arrow) using rabbit polyclonal RENT1 Antibody (N-term E22) (ABIN1882125) . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the RENT1 gene (Lane 2) (Origene Technologies). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IP, PLA, WB Proximity Ligation Assay: RENT1/UPF1/hUPF1 Antibody [NBP1-05967] - Secondary-conjugate Duolink in Situ PLA in Hela cells. goat anti-human RelA (NBP2-22297) and rabbit anti-human RENT1/UPF1/hUPF1 (NBP1-05967). Image merged from DAPI (2ms), FITC/Green (25ms) and Red (200ms) exposures, 40X magnification. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details

UPF1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Antikörper

  1. Human Polyclonal UPF1 Primary Antibody für WB - ABIN151832 : Silva, Pereira, Morgado, Kong, Martins, Faustino, Liebhaber, Romão: The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context. in RNA (New York, N.Y.) 2006 (PubMed)
    Show all 9 Pubmed References

  2. Human Polyclonal UPF1 Primary Antibody für WB - ABIN1882125 : Mendell, ap Rhys, Dietz: Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts. in Science (New York, N.Y.) 2002 (PubMed)
    Show all 6 Pubmed References

  3. Human Polyclonal UPF1 Primary Antibody für IP, PLA - ABIN438392 : Martins, Proença, Silva, Barbosa, Silva, Faustino, Romão: Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels. in PLoS ONE 2012 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal UPF1 Primary Antibody für PLA, WB - ABIN151834 : Luke, Azzalin, Hug, Deplazes, Peter, Lingner: Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. in Nucleic acids research 2008 (PubMed)

  5. Human Polyclonal UPF1 Primary Antibody für WB - ABIN151833 : Silva, Ribeiro, Inácio, Liebhaber, Romão: Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay. in RNA (New York, N.Y.) 2008 (PubMed)

  6. Human Polyclonal UPF1 Primary Antibody für WB - ABIN388607 : Ohnishi, Yamashita, Kashima, Schell, Anders, Grimson, Hachiya, Hentze, Anderson, Ohno: Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. in Molecular cell 2003 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Interaktionspartner

Human UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) Interaktionspartner

  1. HTLV-1 Tax (zeige CNTN2 Antikörper) protein interacts with the central helicase core domain of UPF1 and freezes it, which leads to nonsense-mediated mRNA decay inhibition.

  2. results indicate that UPF1 can dissociate miRNAs from their mRNA targets, making the miRNAs susceptible to Tudor-staphylococcal/micrococcal-like nuclease (zeige DCLRE1C Antikörper) (TSN (zeige TSN Antikörper))-mediated miRNA decay.

  3. Overexpression of UPF1 inhibited cell proliferation, cell cycle progression, cell migration and invasion, and promoted cell apoptosis in gastric cancer cells. Moreover, the UPF1-mediated inhibition of gastric cancer progression was reversed by overexpression of MALAT1.

  4. The nucleic acids processing activities of UPF1 are consistent with its function in mRNA regulation and suggest that roles in DNA replication could also be influenced by base sequence.

  5. MARVELD1 (zeige MARVELD1 Antikörper) substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 and Y14 (zeige RBM8A Antikörper). MARVELD1 (zeige MARVELD1 Antikörper) promotes the dissociation of SMG1 (zeige SMG1 Antikörper) from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5 (zeige SMG5 Antikörper).

  6. UPF1 acts as an E3 ligase via its RING domain to promote MYOD protein ubiquitination and degradation and repress myogenesis.

  7. Upregulation of SNHG6 regulates ZEB1 (zeige ZEB1 Antikörper) expression by competitively binding miR (zeige MLXIP Antikörper)-101-3p and interacting with UPF1 in hepatocellular carcinoma, promoting tumor growth and metastasis.

  8. Study showed that UPF1 was down-regulated due to promoter hypermethylation in hepatocellular carcinoma tissues which correlated with decreased survival.

  9. CARM1 (zeige CARM1 Antikörper) associates with major nonsense-mediated mRNA decay factor UPF1 and promotes its occupancy on premature terminating codon-containing transcripts in spinal muscular atrophy.

  10. Upf1 is a RNA helicase (zeige DDX46 Antikörper) essential for nonsense-mediated mRNA decay. Once recruited onto NMD mRNA targets, Upf1 can scan the entire transcript to irreversibly remodel the mRNP, facilitating its degradation by the NMD machinery.

Mouse (Murine) UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) Interaktionspartner

  1. Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies .

  2. results identify novel nonsense-mediated mRNA decay (NMD) determinants and targets and provide context for understanding the impact of UPF1 and NMD on the murine embryonic stem cell transcriptome

Caenorhabditis elegans (C. elegans) UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) Interaktionspartner

  1. results suggest that the role of SMG-5 (zeige ZCCHC11 Antikörper) is to direct protein phosphatase 2A to its SMG-2 substrate

  2. SMG-2 interacts with SMG-3 (zeige UPF2 Antikörper), SMG-3 (zeige UPF2 Antikörper) interacts with SMG-4, and SMG-2 interacts indirectly with SMG-4 via shared interactions with SMG-3 (zeige UPF2 Antikörper). SMG-2 preferentially associates with PTC (zeige PTCH1 Antikörper)-containing mRNAs.

UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) Antigen-Profil

Protein Überblick

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.

Genbezeichner und Symbole assoziert mit UPF1

  • UPF1, RNA helicase and ATPase (UPF1) Antikörper
  • UPF1 regulator of nonsense transcripts homolog (yeast) (Upf1) Antikörper
  • upf1 regulator of nonsense transcripts homolog (yeast) (upf1) Antikörper
  • regulator of nonsense transcripts 1 (Tc00.1047053511317.30) Antikörper
  • regulator of nonsense transcripts 1 (Tb927.5.2140) Antikörper
  • regulator of nonsense transcripts 1 (TVAG_453890) Antikörper
  • regulator of nonsense transcripts 1 (TVAG_237840) Antikörper
  • regulator of nonsense transcripts 1 (AOR_1_1018194) Antikörper
  • regulator of nonsense transcripts 1 (HPB8_739) Antikörper
  • Regulator of nonsense transcripts 1 (smg-2) Antikörper
  • UPF1, RNA helicase and ATPase (Upf1) Antikörper
  • UPF1 regulator of nonsense transcripts homolog S homeolog (upf1.S) Antikörper
  • AO090012000584 Antikörper
  • B430202H16Rik Antikörper
  • hupf1 Antikörper
  • norf1 Antikörper
  • PNORF-1 Antikörper
  • pnorf1 Antikörper
  • rent1 Antikörper
  • smg-2 Antikörper
  • Tb05.3C6.50 Antikörper
  • upf1 Antikörper
  • Upflp Antikörper
  • wu:fi40f07 Antikörper
  • wu:fj48a01 Antikörper
  • zgc:55472 Antikörper

Bezeichner auf Proteinebene für UPF1

ATP-dependent helicase RENT1 , UP Frameshift 1 , delta helicase , nonsense mRNA reducing factor 1 , regulator of nonsense transcripts 1 , smg-2 homolog, nonsense mediated mRNA decay factor , up-frameshift mutation 1 homolog , up-frameshift suppressor 1 homolog , yeast Upf1p homolog , Regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) , mUpf1 , LOW QUALITY PROTEIN: regulator of nonsense transcripts 1 , UPF1 regulator of nonsense transcripts homolog S homeolog

GENE ID SPEZIES
5976 Homo sapiens
19704 Mus musculus
406783 Danio rerio
420119 Gallus gallus
456373 Pan troglodytes
3541249 Trypanosoma cruzi strain CL Brener
3657316 Trypanosoma brucei brucei strain 927/4 GUTat10.1
4775578 Trichomonas vaginalis G3
5467310 Trichomonas vaginalis G3
5988051 Aspergillus oryzae RIB40
9349309 Helicobacter pylori B8
171696 Caenorhabditis elegans
476664 Canis lupus familiaris
532933 Bos taurus
684558 Rattus norvegicus
100713813 Cavia porcellus
444289 Xenopus laevis
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