Tyrosyl-DNA Phosphodiesterase 1 (TDP1) ELISA Kits

The protein encoded by TDP1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. Zusätzlich bieten wir Ihnen TDP1 Antikörper (97) und TDP1 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
TDP1 55775 Q9NUW8
Anti-Maus TDP1 TDP1 104884  
Anti-Ratte TDP1 TDP1 314380 Q4G056
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Top TDP1 ELISA Kits auf antikoerper-online.de

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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 15.6 pg/mL 62.5-4000 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$910.56
Details
Human
  96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
$374.00
Details

Weitere ELISA Kits für TDP1 Interaktionspartner

Arabidopsis thaliana Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Interaktionspartner

  1. AtTDP plays a clear role in the repair of topoisomerase I (zeige TOP1 ELISA Kits)-DNA complexes.

Human Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Interaktionspartner

  1. Data indicate a molecular basis for DNA 3'-end processing by tyrosyl-DNA phosphodiesterase (Tdp1).

  2. Expression of human Tdp1HisnucAla and Tdp1HisgabAsn mutants results in stabilization of the covalent TDP1-DNA intermediate and induces cytotoxicity.

  3. We show that two genes, TDP1, a tyrosyl-DNA-phosphdiesterase, and TAF12 (zeige TAF12 ELISA Kits), an RNA polymerase II TATA-box binding factor, cause CIN (zeige PDXP ELISA Kits) when overexpressed in human cells. Using SDL screens in yeast, we identified a set of genes that when deleted specifically kill cells with high levels of Tdp1

  4. TDP1 participation in human non-homologous end joining (NHEJ) is mediated by interaction with XLF (zeige NHEJ1 ELISA Kits), and that TDP1-XLF (zeige NHEJ1 ELISA Kits) interactions and subsequent NHEJ events are regulated by phosphorylation of TDP1-S81.

  5. Mutations in TDP1 and APTX have been linked to Spinocerebellar ataxia with axonal neuropathy (SCAN1) and Ataxia-ocular motor apraxia 1 (AOA1), respectively, while mutations in PNKP are considered to be responsible for Microcephaly with seizures (MCSZ) and Ataxia-ocular motor apraxia 4 (AOA4).

  6. The data obtained suggest that PARP1 (zeige PARP1 ELISA Kits) and TDP1 bind in an antiparallel orientation; the N-terminus of the former protein interacts with the C-terminal domain of the latter.

  7. Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2alpha cleavage complexes in human cells.

  8. varying expression levels of TOP1 (zeige TOP1 ELISA Kits) and TDP1 polypeptides in multiple colorectal cancer cell lines and in clinical colorectal cancer samples, are reported.

  9. both TOP1 (zeige TOP1 ELISA Kits) and TDP1 were upregulated in the tumor tissue compared to the adjacent non-tumor tissue in non-small cell lung cancer tissue

  10. Density functional theory computations are used to acquire thermodynamic and kinetic data along the catalytic pathway, including the phosphoryl transfers of Tdp1 and subsequent hydrolysis.

Mouse (Murine) Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Interaktionspartner

  1. These findings provide evidence for TDP1 as a novel mitochondrial enzyme.

  2. The interaction with Lig3alpha is promoted by serine 81 that is located within a putative S/TQ site in the N-terminus domain of TDP1.

  3. Data indicate that TDP1 is required for neural homeostasis and reveal a widespread requisite for TDP1 function in response to acutely elevated levels of DNA topoisomerase I (Top1 (zeige TOP1 ELISA Kits))-associated DNA strand breaks.

  4. This study provides a direct demonstration that Tdp1 repairs Topo I (zeige TOP1 ELISA Kits) covalent lesions in vivo and suggests that spinocerebellar ataxia with axonal neuropathy (SCAN1 (zeige CANT1 ELISA Kits)) arises from the recessive neomorphic mutation H493R.

  5. Tdp1(-/-) fibroblasts exhibited deficiencies in processing 3'-phosphotyrosyl single-strand breaks and 3'-phosphoglycolate double-strand breaks, but not 3'-phosphoglycolate single-strand breaks.

TDP1 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Genbezeichner und Symbole assoziert mit TDP1

  • tyrosyl-DNA Phosphodiesterase (Tdp1) (Tc00.1047053511191.10) Antikörper
  • tyrosyl-DNA phosphodiesterase (Tdp1) (Tc00.1047053506619.40) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 (TDP1) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 L homeolog (tdp1.L) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 (tdp1) Antikörper
  • tyrosyl-DNA phosphodiesterase-like protein (TDP1) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 (PTRG_11198) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 (MCYG_02121) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 (MGYG_03035) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 (Tdp1) Antikörper
  • 2810481F14Rik Antikörper
  • 4921509N21Rik Antikörper
  • AI838772 Antikörper
  • AW493413 Antikörper
  • E430034L06Rik Antikörper
  • F8M21.60 Antikörper
  • F8M21_60 Antikörper
  • MGC83708 Antikörper
  • MLZ-501 Antikörper
  • SCAN1 Antikörper
  • TDP1 Antikörper
  • tyrosyl-DNA phosphodiesterase 1 Antikörper

Bezeichner auf Proteinebene für TDP1

tyrosyl-DNA Phosphodiesterase (Tdp1) , tyrosyl-DNA phosphodiesterase (Tdp1) , tyrosyl-DNA phosphodiesterase 1 , tyrosyl-DNA phosphodiesterase 1-like , tyr-DNA phosphodiesterase 1 , protein expressed in male leptotene and zygotene spermatocytes 501 , tyrosyl-DNA phodphodiesterase 1

GENE ID SPEZIES
3534433 Trypanosoma cruzi strain CL Brener
3543870 Trypanosoma cruzi strain CL Brener
423403 Gallus gallus
446983 Xenopus laevis
453096 Pan troglodytes
517053 Bos taurus
571485 Danio rerio
695338 Macaca mulatta
734106 Xenopus (Silurana) tropicalis
831369 Arabidopsis thaliana
6349511 Pyrenophora tritici-repentis Pt-1C-BFP
9229242 Arthroderma otae CBS 113480
10030819 Arthroderma gypseum CBS 118893
100388128 Callithrix jacchus
100432320 Pongo abelii
100593301 Nomascus leucogenys
55775 Homo sapiens
104884 Mus musculus
314380 Rattus norvegicus
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