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PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family.
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This finding shows that autophagy and NLRP3 (zeige NLRP3 ELISA Kits) inflammasome activation are connected, and that PTPN22 plays a key role in the regulation of those 2 pathways.
Here we show that mice deficient in PTPN22 resist chronic viral infection with lymphocytic choriomeningitis virus clone 13. The numbers and function of viral-specific CD4 (zeige CD4 ELISA Kits) T lymphocytes is greatly enhanced, whereas expression of the IFNbeta-induced IL-2 (zeige IL2 ELISA Kits) repressor, cAMP-responsive element modulator (zeige CREM ELISA Kits) is reduced.
we have discovered that inactivation of Ptpn22 or Mll3 greatly accelerated PI3K-driven mammary tumorigenesis
Our findings, for the first time, illustrate the indirect impact of the 619 Arg > Trp (zeige TYRP1 ELISA Kits) polymorphic PTPN22 on T cells activation, mediated by polymorphic effects on macrophages and indicate a possible role of PTPN22 in cytoskeleton re-arrangement.
PTPN22 has dual roles in T-cell clonal expansion and effector function; whereas it promotes antigen-driven responses during acute infection by positively regulating interferon (zeige IFNA ELISA Kits) signaling in T cells, PTPN22 inhibits homeostatic-driven proliferation.
PTPN22 colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 (zeige ITGAL ELISA Kits) ligand intercellular adhesion molecule-1 (ICAM-1 (zeige ICAM1 ELISA Kits)).
in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.
PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.
collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals
PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 (zeige NLRP3 ELISA Kits) phosphorylation, but reduced levels of mature IL-1beta (zeige IL1B ELISA Kits).
c.1858CC genotype associated with a beneficial functional effect on residual insulin (zeige INS ELISA Kits) secretion and HbA1c level dynamics in type 1 diabetes
present meta-analysis update confirms that T allele and T/T genotype in PTPN22 1858 C > T polymorphism confers SLE susceptibility, particular in Caucasian and Latin groups, suggesting PTPN22 1858 C > T as a potential genetic marker in SLE susceptibility.
There were no significant relationships with PTPN22 SNPs in primary biliary cholangitis (PBC (zeige DLAT ELISA Kits)) patients. Interestingly, the AAGTCCC haplotype was significantly associated with resistance to both Autoimmune hepatitis (odds ratio [OR] = 0.58, P = 0.0067) and PBC (zeige DLAT ELISA Kits) (OR = 0.58, P = 0.0048). SNPs in the PTPN22 gene may therefore play key roles in the genetic resistance to autoimmune liver disease in the Japanese.
Studied association of and RNASET2 (zeige RNASET2 ELISA Kits), GPR174, and PTPN22 gene polymorphisms and liver damage(LD) due to Graves' disease (GD) hyperthyroidism. Found GPR174 rs3827440, PTPN22 rs3789604, and RNASET2 (zeige RNASET2 ELISA Kits) rs9355610 were significantly associated with altered GD-derived LD risk.
PTPN22 is hypermethylated in esophageal squamous cell carcinoma
A higher prevalence of homozygous PTPN22 -1123CC genotype was found in controls than in rheumatoid arthritis (RA) patients, suggesting a potential protective effect against RA. Concerning anti-cyclic citrullinated protein antibodies levels, the CC genotype carriers showed the lowest median levels in RA.
Our data provide the first demonstration that PTPN22 R620W confers Graves Disease susceptibility among Latin-American patients.
The GG genotype of PTPN22 rs6665194 (-3508A>G) is associated with significantly reduced risk of Rheumatoid Arthritis in Asians.
PTPN22 rs2476601 was related to systemic lupus erythematosus in Americans, Europeans, and Africans.[meta-analysis]
the rs1310182 SNP of the PTPN22 gene may be a predisposing factor of celiac disease in the Iranian population
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
PEST domain-enriched tyrosine phosphatase
, hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
, protein tyrosine phosphatase, non-receptor type 8
, tyrosine-protein phosphatase non-receptor type 22
, PEST-domain phosphatase
, lymphoid phosphatase
, lymphoid-specific protein tyrosine phosphatase