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PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Zusätzlich bieten wir Ihnen PTPN22 Antikörper (66) und PTPN22 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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we have discovered that inactivation of Ptpn22 or Mll3 greatly accelerated PI3K-driven mammary tumorigenesis
Our findings, for the first time, illustrate the indirect impact of the 619 Arg > Trp (zeige TYRP1 ELISA Kits) polymorphic PTPN22 on T cells activation, mediated by polymorphic effects on macrophages and indicate a possible role of PTPN22 in cytoskeleton re-arrangement.
PTPN22 has dual roles in T-cell clonal expansion and effector function; whereas it promotes antigen-driven responses during acute infection by positively regulating interferon (zeige IFNA ELISA Kits) signaling in T cells, PTPN22 inhibits homeostatic-driven proliferation.
PTPN22 colocalized with its substrates at the leading edge of cells migrating on surfaces coated with the LFA-1 (zeige ITGAL ELISA Kits) ligand intercellular adhesion molecule-1 (ICAM-1 (zeige ICAM1 ELISA Kits)).
in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.
PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.
collective murine and human data provide an alternative model for how the PTPN22 C1858T variant promotes self-reactivity into the naive B cell repertoire and, consequently, is likely to increase the probability of triggering autoimmune B cell responses in at-risk individuals
PTPN22 deficiency resulted in pronounced colitis, increased NLRP3 (zeige NLRP3 ELISA Kits) phosphorylation, but reduced levels of mature IL-1beta (zeige IL1B ELISA Kits).
We show that PTPN22 deficiency enhanced T-cell receptor-mediated signaling in SKG Ptpn22-/- thymocytes and that the early stages of thymus positive selection were partially restored in SKG Ptpn22-/- mice.
this study shows that neutrophil effector functions are reduced in Ptpn22-/- neutrophils, and that Ptpn22-/- mice are protected from immune complex-mediated arthritis
PTPN22 rs2476601 was related to systemic lupus erythematosus in Americans, Europeans, and Africans.[meta-analysis]
the rs1310182 SNP of the PTPN22 gene may be a predisposing factor of celiac disease in the Iranian population
PTPN22 polymorphisms may have a role in risk of ankylosing spondylilitis [meta-analysis]
Analysis of PTPN22, ZFAT and MYO9B polymorphisms in Turner Syndrome and risk of autoimmune disease.
Our study supports an association between the PTPN22 gene polymorphism rs2476601 and an increased risk for Type 1 diabetes in children
PTPN22 single nucleotide polymorphism is associated with type 1 diabetes in Iran
Relationship with insulin (zeige INS ELISA Kits)-dependent diabetes mellitus was found only in polymorphism R620W
The associations observed between PTPN22 (C1858T) and the risk of endometriosis suggest this polymorphism might be a useful susceptibility marker for this disease.
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
PEST domain-enriched tyrosine phosphatase
, hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
, protein tyrosine phosphatase, non-receptor type 8
, tyrosine-protein phosphatase non-receptor type 22
, PEST-domain phosphatase
, lymphoid phosphatase
, lymphoid-specific protein tyrosine phosphatase