Tyrosine Kinase, Non-Receptor, 1 Proteine (TNK1)

The protein encoded by TNK1 belongs to the tyrosine protein kinase family. Zusätzlich bieten wir Ihnen TNK1 Antikörper (126) und TNK1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TNK1 83813 Q99ML2
TNK1 8711 Q13470
Ratte TNK1 TNK1 303247  
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$624.55
Details

TNK1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
,

Weitere Proteine zu Tyrosine Kinase, Non-Receptor, 1 (TNK1) Interaktionspartnern

Mouse (Murine) Tyrosine Kinase, Non-Receptor, 1 (TNK1) Interaktionspartner

  1. The activated TNK1 potentiates JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine) signaling through dual phosphorylation of STAT1 (zeige STAT1 Proteine) at tyrosine 701 and serine 727 amino acid positions.

  2. data support a negative regulatory role for Kos1 in regulating the Ras-Raf1 (zeige RAF1 Proteine)-MAPK (zeige MAPK1 Proteine) growth pathway by a mechanism that requires its autotyrosine kinase activity

  3. Tnk1/Kos1 is a tumor suppressor that functions to down-regulate Ras activity

  4. cellular stress reverses the repression of Tnk1/Kos1 and induces its expression through increased high affinity interactions between nuclear proteins Sp1 (zeige SP1 Proteine), Sp3, AP2 (zeige TFAP2A Proteine) and MED1 (zeige MBD4 Proteine) for the m-Tnk1 promoter

Human Tyrosine Kinase, Non-Receptor, 1 (TNK1) Interaktionspartner

  1. The activated TNK1 potentiates JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine) signaling through dual phosphorylation of STAT1 (zeige STAT1 Proteine) at tyrosine 701 and serine 727 amino acid positions.

  2. The application of functional genomics by using high-throughput-RNAi screens has allowed us to identify TNK1 as a growth-associated kinase in pancreatic cancer cells.

  3. Activated Tnk1 kinase is associated with Hodgkin's lymphoma.

  4. TNK1 therefore acts as a novel molecular switch that can determine the properties of TNFalpha (zeige TNF Proteine) signaling and therefore cell death.

TNK1 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit TNK1

  • tyrosine kinase non receptor 1 (TNK1)
  • tyrosine kinase, non-receptor, 1 (Tnk1)
  • tyrosine kinase non receptor 1 (Tnk1)
  • Ack-like Protein
  • Kos1 Protein
  • Tnk1a Protein
  • Tnk1b Protein

Bezeichner auf Proteinebene für TNK1

kinase of embryonic stem cells , non-receptor tyrosine kinase , non-receptor tyrosine-protein kinase TNK1 , CD38 negative kinase 1

GENE ID SPEZIES
100061776 Equus caballus
83813 Mus musculus
8711 Homo sapiens
303247 Rattus norvegicus
510356 Bos taurus
489470 Canis lupus familiaris
100735628 Cavia porcellus
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