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TPCN2 encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. Zusätzlich bieten wir Ihnen TPCN2 Antikörper (40) und TPCN2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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localized calcium (Ca(2 (zeige CA2 ELISA Kits)+)) release via TPC2 might trigger the generation of more global Ca(2 (zeige CA2 ELISA Kits)+) release from the sarcoplasmic reticulum via Ca(2 (zeige CA2 ELISA Kits)+)-induced Ca(2 (zeige CA2 ELISA Kits)+) release.
TPC2-mediated Ca(2 (zeige CA2 ELISA Kits)+) release from lysosomes may act upstream from RyR (zeige RYR1 ELISA Kits)- and IP 3R-mediated Ca(2 (zeige CA2 ELISA Kits)+) release, suggesting that the former might initiate the SR-mediated Ca(2 (zeige CA2 ELISA Kits)+)-induced-Ca(2 (zeige CA2 ELISA Kits)+)-release essential for SMC (zeige DYM ELISA Kits) myogenesis and function.
These findings indicate potential differential regulation of signaling processes by TPC1 and TPC2 in breast cancer cells.
TPC2 regulates pigmentation through two fundamental determinants of melanosome function: pH and size.
Results show that PDGs use previously unknown mechanisms of membrane dynamics and content exchange that are regulated by TPC2.
Here, using live cell imaging, the authors obtained evidence that in contrast to the new model, ebolavirus enters cells through endolysosomes that contain both NPC1 (zeige NPC1 ELISA Kits) and TPC2.
Studies suggest that both two-pore channels TPC1 and TPC2 as nicotinic acid adenine dinucleotide phosphate (NAADP) targets.
TPC2 is thus a potential drug target within a pathogenic LRRK2 cascade that disrupts Ca(2 (zeige CA2 ELISA Kits)+)-dependent trafficking in Parkinson disease
SNPs within Tpcn2 are associated with fasting insulin in humans.
NAADP induced marked Ca(2 (zeige CA2 ELISA Kits)+) transients in HEK293 cells that stably coexpressed hTPC2 with hTPC1 or cTPC3, but failed to evoke any such response in cells that coexpressed interacting hTPC2 and rTPC3 subunits
TPC2, but not TPC1, caused a proliferation of endolysosomal structures, dysregulating intracellular trafficking, and cellular pigmentation.
These results demonstrate that a VEGFR2 (zeige KDR ELISA Kits)/NAADP/TPC2/Ca(2 (zeige CA2 ELISA Kits)+) signaling pathway is critical for VEGF (zeige VEGFA ELISA Kits)-induced angiogenesis
High TPC2 expression is associated with lung metastasis in breast cancer.
Electron micrographs of hearts from TPC1/TPC2 double knockout mice showed that cardiomyocytes contained large numbers of immature lysosomes compared to wild-type mice.
observations define a role for NAADP and TPC2 at lysosomal/sarcoplasmic reticulum junctions as unexpected but major contributors in the acute actions of beta-adrenergic signaling in the heart
TPC2 plays a crucial role in trafficking in the endolysosomal degradation pathway and in fatty liver disease.
Genetic ablation of endolysosomal TPC1 or TPC2 channels attenuates glucose- and sulfonylurea-induced membrane currents, depolarization, cytoplasmic Ca2 (zeige CA2 ELISA Kits)+ signals, and insulin (zeige INS ELISA Kits) secretion in pancreatic beta cells.
Tpcn2 knockout mice demonstrated a significant decrease in fasting glucose levels and insulin (zeige INS ELISA Kits) response to a glucose challenge.
Mice lacking TPC2 display muscle atrophy and altered autophagy.
It was concluded that Tpcn1/2(-/-) mice show mature-onset obesity due to reduced lipid availability and use, and a defect in beta-adrenergic receptor signaling, leading to impaired thermogenic activity, in brown adipose tissue.
Findings indicate that TPC2 have important but distinct roles from TPC1 in the endo-lysosomal pathway.
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.
two pore calcium channel protein 2
, voltage-dependent calcium channel protein TPC2
, two pore segment channel 2
, two pore calcium channel protein 2-like
, two-pore calcium channel protein 2