Tumor Necrosis Factor Receptor Superfamily, Member 19 (TNFRSF19) ELISA Kits

Human Tumor Necrosis Factor Receptor Superfamily, Member 19 (TNFRSF19) Interaktionspartner

1. isruption of the TROY/RKIP interaction using the TAT-TROY (234-371 aa) protein reduced the glioma development in xenografted mice. This suggests the TROY/RKIP interaction is a potential target for therapy of gliomas.

2. TROY signaling role in the glioblastoma cell invasion and survival.PDZ-RhoGEF is an effector of TROY signaling.

3. Glioblastoma tumors (GB) with elevated TROY expression have a statistically positive correlation with increased EGFR expression. TROY expression significantly increases the capacity of EGF to stimulate GB cell invasion, whereas depletion of TROY expression blocks EGF stimulation of glioblastoma cell invasion. TROY expression modulates EGFR signaling by facilitating EGFR activation and delaying its internalization.

4. TNFRSF19 may contribute to the development of colorectal tumors with deregulated beta-catenin activity.

5. Results show aberrant expression and/or signaling by TROY as a contributor to the dispersion of glioblastoma cells and therapeutic resistance.

6. the association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation.

7. TROY is up-regulated in human colorectal cancer cell lines and in intestinal tumors in mice. It functions as a negative modulator of the Wnt pathway in LGR5-positive stem cells.

8. study demonstrated that TNFR2 and TROY mRNA levels are enhanced in cutaneous squamous cell carcinoma cells compared to healthy ones in a Tunisian population

9. The FAM134B and TNFRSF19 showed a dramatically strong synergistic epistasis in explaining the genetic dissection of the susceptibility to complex vascular dementia.

10. TNFRSF19 overexpression in glioma cells activates Rac1 signaling in a Pyk2-dependent manner to drive glioma cell invasion and migration

11. Findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules.

12. TROY regulates melanoma growth.

13. the ternary complex of NgR/TROY/LINGO-1 expressed on astrocytes, macrophages/microglia and neurones, by interacting with Nogo-A on oligodendrocytes, might modulate glial-neuronal interactions in demyelinating lesions of multiple sclerosis

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 19 (TNFRSF19) Interaktionspartner

1. data show that Troy marks a renal stem/progenitor cell population in the developing kidney that in adult kidney contributes to homeostasis, predominantly of the collecting duct, and regeneration.

2. High TROY expression is associated with glioblastoma cell invasion.

3. TROY negatively modulates remyelination in the central nervous system.

4. the association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation.

5. TROY is up-regulated in human colorectal cancer cell lines and in intestinal tumors in mice. It functions as a negative modulator of the Wnt pathway in LGR5-positive stem cells.

6. TROY is expressed in microglia, involved in their migration and targeted by propentofylline.

7. TROY plays some important roles in neurogenesis of embryonic stages.

8. This gene was a target of WNT signaling in the dorsal somite.

9. Analysis of expression patterns of eda, edar and tnfrsf19 in mouse embryogenesis.

10. Both mRNA and protein of TROY are detected in the olfactory bulb during embryogenesis; TROY expression is most intense in the inner layer. In the postnatal olfactory bulb, TROY-expressing cells are also detected in the glomerular layer.

11. Our results implicate TROY in mediating myelin inhibition, offering new insights into the molecular mechanisms of regeneration failure in the adult nervous system.

12. Troy, broadly expressed in postnatal and adult neurons, binds to NgR1 and can replace p75 in the p75/NgR1/LINGO-1 complex to activate RhoA in the presence of myelin inhibitors.

13. Data suggest that signaling from TROY regulates neuronal differentiation at least in part.

14. TROY was expressed in uncommitted precursor cells and astroglial lineage cells, suggesting that TROY plays some roles in the regulation of gliogenesis in the adult CNS.

15. Troy protein is expressed in the matrix region of developing hair follicles and may have a subtle function in skin appendage development.

16. TROY was expressed in some specific subsets of glial cells in the olfactory bulb, including OECs, and may play some roles in the developing and adult olfactory system

17. functional overlap of Troy and Eda signalling pathways is mediated by NF-kappaB independent pathways