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May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. Zusätzlich bieten wir Ihnen Tppp Antikörper (82) und Tppp Kits (35) und viele weitere Produktgruppen zu diesem Protein an.
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The knowledge accumulated so far underlines the key roles of the multifunctional TPPP/p25 in both physiological and diverse pathological processes, consequently its validation as drug target sorely needs a new innovative strategy that is briefly reviewed here.
TPPP may have a role in poor prognosis in hepatocellular carcinoma
the central folded domain of TPPP/p25 following binding to microtubules can drive s homotypic protein-protein interactions leading to bundled microtubules.
Results reveal a link between p25 (zeige LCN2 Proteine) and BACE1 (zeige BACE Proteine) in Alzheimer disease (AD) brains and suggest that upregulated Cdk5 (zeige CDK5 Proteine) activation by p25 (zeige LCN2 Proteine) accelerates AD pathogenesis by enhancing BACE1 (zeige BACE Proteine) activity via phosphorylation.
Epigenetic changes in TPPP, in combination with experiences of maltreatment, may confer risk for depression in children.
suggest that the zinc as a specific divalent cation could be involved in the fine-tuning of the physiological TPPP/p25 level counteracting both the enrichment and the lack of this protein leading to distinct central nervous system diseases
results suggest that ROCK regulates beta-catenin stability in cells via preventing TPPP1-mediated inhibition of HDAC6 activity, to reduce its acetylation and degradation via phosphorylation by CK1 and GSK3beta
GSK3 promotes the mitochondrial translocation of p53 (zeige TP53 Proteine), enabling its interaction with Bcl2 (zeige BCL2 Proteine) to allow Bax (zeige BAX Proteine) oligomerization and the subsequent release of cytochrome C (zeige CYCS Proteine).
dual Rock and Cdk (zeige CDK4 Proteine) phosphorylation of Tppp1 inhibits its regulation of the cell cycle to increase cell proliferation
The RhoA (zeige RHOA Proteine)-ROCK-LIMK2 (zeige LIMK2 Proteine)-TPPP pathway controls metaphase spindle-orientation; TPPP colocalizes with LIMK2 (zeige LIMK2 Proteine) at the mitotic spindle.
The present study provides additional support for roles for TPPP in the etiology of depression following early adversity.
These results support an essential role for TPPP/p25 in oligodendrocyte differentiation likely via rearrangement of the microtubule system during the process elongation prior to the onset of myelination.
LIMK1 phosphorylation of p25 blocks p25 activity, thus promoting microtubule disassembly.
A pathway was discovered by which p25 (zeige CDK5R1 Proteine) and cdk5 (zeige CDK5 Proteine) increases the amyloidogenic processing of amyloid precursor protein (zeige APP Proteine).
May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
brain-specific protein p25 alpha
, 25 kDa brain-specific protein
, brain specific protein p25 alpha
, glycogen synthase kinase 3 (GSK3) inhibitor p24
, tubulin polymerization-promoting protein
, tubulin polymerization promoting protein p25 alpha