Tripartite Motif Containing 37 Proteine (TRIM37)

TRIM37 encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. Zusätzlich bieten wir Ihnen TRIM37 Antikörper (58) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte TRIM37 TRIM37 360592  
TRIM37 4591 O94972
TRIM37 68729 Q6PCX9
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Showing 4 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Wheat germ Human GST tag 10 μg 11 bis 12 Tage
Baculovirus infected Insect Cells Human GST tag   20 μg 1 bis 2 Tage

TRIM37 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
Mouse (Murine)

Weitere Proteine zu Tripartite Motif Containing 37 (TRIM37) Interaktionspartnern

Human Tripartite Motif Containing 37 (TRIM37) Interaktionspartner

  1. TRIM37 functions as an oncogene in the development and progression of glioma.

  2. TRIM37 mutation is associated with mulibrey nanism.

  3. TRIM37-mediated ubiquitylation stabilizes PEX5 and promotes peroxisomal matrix protein import, suggesting that mulibrey nanism is a new peroxisomal biogenesis disorder.

  4. TRIM37 was overexpressed in human CRC tissues. High TRIM37 expression resulted in increased CRC proliferation, migration and invasion. Mechanistically, it was confirmed that TRIM37 enhanced invasion and metastasis of CRC via the epithelialmesenchymal transition pathway.

  5. knockdown of TRIM37 markedly downregulated the expression of beta-catenin, cyclin D1, and c-Myc in CRC cells. These results suggest that knockdown of TRIM37 inhibits proliferation and tumorigenesis by the inactivation of Wnt/beta-catenin signaling in CRC cells.

  6. The oncogenic roles of TRIM37 in pancreatic cancer.

  7. These finding may provide insight into the understanding of TRIM37 as a novel critical factor of HCC and a candidate target for HCC treatment.

  8. results reveal TRIM37 as an oncogenic H2A ubiquitin ligase that is overexpressed in a subset of breast cancers and promotes transformation by facilitating silencing of tumour suppressors and other genes.

  9. Our report underlines the necessity of early clinical diagnosis of Mulibrey nanism. Careful cardiologic examination is required to detect constrictive pericarditis, which is a major factor of mortality in these patients

  10. In this study, authors demonstrate that human Trim 37 possesses anti-HIV-1 activity.

  11. The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder

  12. novel splice variants observed in lymphoblastoid cells and muscle tissue of normal subjects and mulibrey nanism patients

  13. The TRIM37 acts as a TRIM domain-dependent E3 ubiquitin ligase and imply defective ubiquitin-dependent degradation of an as-yet-unidentified target protein in the pathogenesis of mulibrey nanism.

  14. Functional link of TRIM37 to the ubiquitin-proteosome pathway may provide novel clues to the development of metabolic syndrome.

  15. TRIM37 expression is regulated by several mechanisms: through nonsense surveillance of non-functional transcripts, as well as through 3'UTR regulatory sequences and/or naturally occurring antisense RNAs especially in testis.

  16. Novel mutations in the tumor necrosis factor receptor associated factor (TRAF) domain alter the subcellular localization of TRIM37, and are associated with Wilm's tumor in a patient with mulibrey nanism.

  17. Mutation screening of the TRIM37 gene revealed that the proband had a homozygous two base pair deletion, c.1894_1895delGA, resulting in a frame-shift and a premature termination codon.

  18. inherited biallelic inactivation of TRIM37 (Mulibrey nanism) predisposes to both mesenchymal and epithelial ovarian tumors and dysregulation of TRIM37 may also be involved in the pathogenesis of sporadic fibrothecomas.

Mouse (Murine) Tripartite Motif Containing 37 (TRIM37) Interaktionspartner

  1. Trim37 deficiency in mouse lead to infertility, prenatal-onset growth failure, infertility, cardiopathy, risk for tumors, fatty liver, and type 2 diabetes.

  2. We here show that the mouse Trim37 gene presents several alternative splice variants, including a testis-specific transcript with an additional 3' exon.

TRIM37 Protein Überblick

Protein Überblick

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.

Genbezeichner und Symbole assoziert mit TRIM37

  • tripartite motif-containing 37 (Trim37)
  • tripartite motif containing 37 (TRIM37)
  • 1110032A10Rik Protein
  • 2810004E07Rik Protein
  • AI848587 Protein
  • AU043018 Protein
  • mKIAA0898 Protein
  • MUL Protein
  • POB1 Protein
  • TEF3 Protein

Bezeichner auf Proteinebene für TRIM37

E3 ubiquitin-protein ligase TRIM37 , tripartite motif protein 37 , tripartite motif-containing 37 , tripartite motif-containing 37 protein , tripartite motif-containing protein 37 , E3 ubiquitin-protein ligase TRIM37-like , tripartite motif containing 37 , RING-B-box-coiled-coil protein , mulibrey nanism protein , TRAF encompassing factor 3

360592 Rattus norvegicus
417628 Gallus gallus
455163 Pan troglodytes
100010737 Monodelphis domestica
100057121 Equus caballus
100225193 Taeniopygia guttata
100403783 Callithrix jacchus
100435296 Pongo abelii
100467093 Ailuropoda melanoleuca
100518931 Sus scrofa
100550103 Meleagris gallopavo
100583751 Nomascus leucogenys
4591 Homo sapiens
480575 Canis lupus familiaris
617078 Bos taurus
68729 Mus musculus
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